ATE407126T1 - Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on - Google Patents

Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on

Info

Publication number
ATE407126T1
ATE407126T1 AT06763143T AT06763143T ATE407126T1 AT E407126 T1 ATE407126 T1 AT E407126T1 AT 06763143 T AT06763143 T AT 06763143T AT 06763143 T AT06763143 T AT 06763143T AT E407126 T1 ATE407126 T1 AT E407126T1
Authority
AT
Austria
Prior art keywords
fluoromethyl
furan
dihydro
preparation
formula
Prior art date
Application number
AT06763143T
Other languages
English (en)
Inventor
Stefan Abrecht
Jean-Michel Adam
Alec Fettes
Joseph Foricher
Bruno Lohri
Patrizio Mattei
Gerard Moine
Rudolf Schmid
Ulrich Zutter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE407126T1 publication Critical patent/ATE407126T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT06763143T 2005-05-24 2006-05-15 Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on ATE407126T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05104408 2005-05-24

Publications (1)

Publication Number Publication Date
ATE407126T1 true ATE407126T1 (de) 2008-09-15

Family

ID=36764569

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06763143T ATE407126T1 (de) 2005-05-24 2006-05-15 Herstellung von (s)-4-fluormethyl-dihydro-furan-2-on

Country Status (15)

Country Link
US (1) US7619101B2 (de)
EP (1) EP1893595B1 (de)
JP (1) JP4219975B2 (de)
KR (1) KR100927910B1 (de)
CN (1) CN101180282B (de)
AT (1) ATE407126T1 (de)
AU (1) AU2006251253B2 (de)
BR (1) BRPI0611196A2 (de)
CA (1) CA2607927C (de)
DE (1) DE602006002612D1 (de)
ES (1) ES2313672T3 (de)
IL (1) IL187001A (de)
MX (1) MX2007014494A (de)
TW (1) TWI310767B (de)
WO (1) WO2006125728A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2662419A1 (en) * 2006-09-15 2008-03-20 Stefan Abrecht Process for the preparation of pyrido[2,1-a]isoquinoline derivatives by catalytic asymmetric hydrogenation of an enamine
US7956201B2 (en) * 2006-11-06 2011-06-07 Hoffman-La Roche Inc. Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one
US20090105480A1 (en) * 2007-08-30 2009-04-23 Ulrike Bromberger Process for the preparation of a dpp-iv inhibitor
US20090163718A1 (en) * 2007-12-19 2009-06-25 Stefan Abrecht PROCESS FOR THE PREPARATION OF PYRIDO[2,1-a] ISOQUINOLINE DERIVATIVES
EP3068770B1 (de) * 2013-11-15 2019-10-23 F.Hoffmann-La Roche Ag Verfahren zur herstellung von pyrimidinylcyclopentanverbindungen
CN108558797B (zh) * 2018-05-28 2020-04-17 华南师范大学 双醚化呋喃酮含氟衍生物及其制备方法与在制备抗肿瘤药物中的应用
CN113620913A (zh) * 2021-07-26 2021-11-09 安徽华业香料股份有限公司 一种γ-壬烯内酯的合成方法
CN117510376A (zh) * 2023-10-17 2024-02-06 四川新迪生物制药有限公司 一种手性联芳基取代的4-氨基-丁酸及其衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59205555D1 (de) * 1991-03-15 1996-04-11 Hoffmann La Roche Chirale phosphine
US6545165B1 (en) * 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
DE10157533A1 (de) * 2001-11-23 2003-06-05 Bayer Cropscience Ag Verfahren zur Herstellung von chiral, nicht-racemischen 5-substituierten gamma-Butyrolactonen
ITMI20020415A1 (it) * 2002-03-01 2003-09-01 Chemi Spa Catalizzatori metallici per reazione chemo- regio- stereo-selettive erelativi precursori
DK1638970T3 (da) * 2003-06-20 2011-01-03 Hoffmann La Roche Pyrid (2, 1-A)-isoquinolinderivater som DPP-IV-inhibitorer

Also Published As

Publication number Publication date
WO2006125728A1 (en) 2006-11-30
US7619101B2 (en) 2009-11-17
AU2006251253A1 (en) 2006-11-30
CN101180282A (zh) 2008-05-14
JP4219975B2 (ja) 2009-02-04
CA2607927A1 (en) 2006-11-30
JP2008545673A (ja) 2008-12-18
IL187001A (en) 2012-08-30
CN101180282B (zh) 2011-09-21
BRPI0611196A2 (pt) 2010-08-24
MX2007014494A (es) 2008-02-11
EP1893595B1 (de) 2008-09-03
US20060270853A1 (en) 2006-11-30
KR100927910B1 (ko) 2009-11-19
TW200722425A (en) 2007-06-16
IL187001A0 (en) 2008-02-09
TWI310767B (en) 2009-06-11
AU2006251253B2 (en) 2012-03-15
ES2313672T3 (es) 2009-03-01
CA2607927C (en) 2014-12-30
KR20080012885A (ko) 2008-02-12
DE602006002612D1 (de) 2008-10-16
EP1893595A1 (de) 2008-03-05

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