BRPI0509720A - derivados de 4-alquil- e 4-alcanoil-piperidina substituìda e seu uso como antagonistas de neurocinina - Google Patents
derivados de 4-alquil- e 4-alcanoil-piperidina substituìda e seu uso como antagonistas de neurocininaInfo
- Publication number
- BRPI0509720A BRPI0509720A BRPI0509720-7A BRPI0509720A BRPI0509720A BR PI0509720 A BRPI0509720 A BR PI0509720A BR PI0509720 A BRPI0509720 A BR PI0509720A BR PI0509720 A BRPI0509720 A BR PI0509720A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- substituted
- antagonist activity
- alkanoyl
- piperidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DE 4-ALQUIL- E 4-ALCANOIL-PIPERIDINA SUBSTITUìDA E SEU USO COMO ANTAGONISTAS DE NEUROCININA. A presente invenção refere-se a derivados de 4-alquil- e 4-alcanoil-piperidina substituída tendo atividade antagonista de neurocinina, em particular atividade antagonista de NKC~ 1~ e uma atividade antagonista combinada de NK~ 1~/NK~ 3~ composições contendo os mesmos e seu uso como medicamento, em particular para o tratamento e/ou profilaxia de esquizofrenia, êmese, ansiedade e depressão, síndrome do intestino irritável (IBS), distúrbios do ritmo circadiano, pré-eclâmpsia, nocicepção, dor, em particular dor visceral e neuropática, pancreatite, inflamação neurogênica. asma, doença pulmonar obstrutiva crónica (COPD) e distúrbios de micção tal como incontinência urinária. Os compostos de acordo com a invenção podem ser representados pela Fórmula geral (I) e compreendem também os sais de adição de ácido ou de base básica farmaceuticamente aceitáveis, as formas isoméricas dos mesmos, a forma N-óxido dos mesmos e pró-drogas dos mesmos, em que todos os substituintes são definidos como na reivindicação 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04101467 | 2004-04-08 | ||
PCT/EP2005/051509 WO2005097774A1 (en) | 2004-04-08 | 2005-04-04 | Substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0509720A true BRPI0509720A (pt) | 2007-09-25 |
Family
ID=34928945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0509720-7A BRPI0509720A (pt) | 2004-04-08 | 2005-04-04 | derivados de 4-alquil- e 4-alcanoil-piperidina substituìda e seu uso como antagonistas de neurocinina |
Country Status (23)
Country | Link |
---|---|
US (1) | US20070213346A1 (pt) |
EP (1) | EP1737838B1 (pt) |
JP (1) | JP2007532516A (pt) |
KR (1) | KR20070007347A (pt) |
CN (1) | CN1938291B (pt) |
AR (1) | AR048532A1 (pt) |
AT (1) | ATE396185T1 (pt) |
AU (1) | AU2005231986B2 (pt) |
BR (1) | BRPI0509720A (pt) |
CA (1) | CA2561967A1 (pt) |
DE (1) | DE602005007002D1 (pt) |
EA (1) | EA010312B1 (pt) |
ES (1) | ES2307169T3 (pt) |
IL (1) | IL178461A0 (pt) |
JO (1) | JO2525B1 (pt) |
MX (1) | MXPA06011683A (pt) |
MY (1) | MY142773A (pt) |
NO (1) | NO20065022L (pt) |
NZ (1) | NZ550098A (pt) |
PA (1) | PA8628901A1 (pt) |
TW (1) | TWI358298B (pt) |
WO (1) | WO2005097774A1 (pt) |
ZA (1) | ZA200608356B (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7659275B2 (en) * | 2005-02-23 | 2010-02-09 | Schering Corporation | Piperidinyl piperazine derivatives useful as inhibitors of chemokine receptors |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
TW200841879A (en) | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
ES2422718T3 (es) * | 2009-04-02 | 2013-09-13 | Merck Patent Gmbh | Derivados de piperidina y piperazina como inhibidores de la autotaxina |
CN102428069B (zh) | 2009-04-02 | 2014-04-02 | 盐野义制药株式会社 | 丙烯酰胺化合物及其用途 |
JP5806672B2 (ja) * | 2009-10-30 | 2015-11-10 | ドメイン・セラピューティクス | 新規オキシム誘導体及び代謝型グルタミン酸受容体のアロステリック調節因子としての利用 |
KR101716099B1 (ko) * | 2013-09-12 | 2017-03-13 | 에프. 호프만-라 로슈 아게 | 인돌-카복스아마이드 유도체 |
RU2743206C2 (ru) | 2015-05-18 | 2021-02-16 | Кэнди Терапьютикс Лимитед | Двойные антагонисты рецептора нейрокинин-1/нейрокинин-3 для лечения заболеваний, зависимых от половых гормонов |
AU2019233606A1 (en) | 2018-03-14 | 2020-09-17 | KaNDy Therapeutics Limited | Novel pharmaceutical formulation comprising dual NK-1/NK-3 receptor antagonists |
ES2963356T3 (es) * | 2019-06-12 | 2024-03-26 | Nouryon Chemicals Int Bv | Método para aislar ácido carboxílico a partir de una corriente lateral acuosa |
JP7336541B2 (ja) | 2019-06-12 | 2023-08-31 | ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ | 過酸化ジアシルを生成するためのプロセス |
HUE063796T2 (hu) | 2019-06-12 | 2024-01-28 | Nouryon Chemicals Int Bv | Eljárás diacil-peroxidok elõállítására |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ321575A (en) * | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
GB0025354D0 (en) * | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
US6642226B2 (en) * | 2001-02-06 | 2003-11-04 | Hoffman-La Roche Inc. | Substituted phenyl-piperidine methanone compounds |
US7514424B2 (en) * | 2002-12-23 | 2009-04-07 | Janssen Pharmaceutica N.V. | Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists |
-
2005
- 2005-03-22 JO JO200534A patent/JO2525B1/en active
- 2005-04-04 AT AT05729797T patent/ATE396185T1/de active
- 2005-04-04 KR KR1020067021935A patent/KR20070007347A/ko not_active Application Discontinuation
- 2005-04-04 ES ES05729797T patent/ES2307169T3/es active Active
- 2005-04-04 AU AU2005231986A patent/AU2005231986B2/en not_active Ceased
- 2005-04-04 JP JP2007506775A patent/JP2007532516A/ja not_active Ceased
- 2005-04-04 CA CA002561967A patent/CA2561967A1/en not_active Abandoned
- 2005-04-04 NZ NZ550098A patent/NZ550098A/en unknown
- 2005-04-04 DE DE602005007002T patent/DE602005007002D1/de active Active
- 2005-04-04 WO PCT/EP2005/051509 patent/WO2005097774A1/en active IP Right Grant
- 2005-04-04 BR BRPI0509720-7A patent/BRPI0509720A/pt not_active IP Right Cessation
- 2005-04-04 US US11/547,868 patent/US20070213346A1/en not_active Abandoned
- 2005-04-04 EA EA200601880A patent/EA010312B1/ru not_active IP Right Cessation
- 2005-04-04 MX MXPA06011683A patent/MXPA06011683A/es active IP Right Grant
- 2005-04-04 EP EP05729797A patent/EP1737838B1/en active Active
- 2005-04-04 CN CN2005800108231A patent/CN1938291B/zh not_active Expired - Fee Related
- 2005-04-05 PA PA20058628901A patent/PA8628901A1/es unknown
- 2005-04-06 MY MYPI20051549A patent/MY142773A/en unknown
- 2005-04-07 AR ARP050101376A patent/AR048532A1/es not_active Application Discontinuation
- 2005-04-07 TW TW094110941A patent/TWI358298B/zh not_active IP Right Cessation
-
2006
- 2006-10-05 IL IL178461A patent/IL178461A0/en unknown
- 2006-10-06 ZA ZA200608356A patent/ZA200608356B/en unknown
- 2006-11-03 NO NO20065022A patent/NO20065022L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2561967A1 (en) | 2005-10-20 |
JP2007532516A (ja) | 2007-11-15 |
DE602005007002D1 (de) | 2008-07-03 |
TW200603797A (en) | 2006-02-01 |
CN1938291B (zh) | 2011-11-16 |
AU2005231986A1 (en) | 2005-10-20 |
CN1938291A (zh) | 2007-03-28 |
KR20070007347A (ko) | 2007-01-15 |
US20070213346A1 (en) | 2007-09-13 |
EP1737838A1 (en) | 2007-01-03 |
PA8628901A1 (es) | 2006-09-08 |
MXPA06011683A (es) | 2006-12-14 |
ATE396185T1 (de) | 2008-06-15 |
ES2307169T3 (es) | 2008-11-16 |
NZ550098A (en) | 2009-10-30 |
IL178461A0 (en) | 2007-02-11 |
AR048532A1 (es) | 2006-05-03 |
EA200601880A1 (ru) | 2007-02-27 |
WO2005097774A1 (en) | 2005-10-20 |
EP1737838B1 (en) | 2008-05-21 |
AU2005231986B2 (en) | 2011-02-24 |
MY142773A (en) | 2010-12-31 |
EA010312B1 (ru) | 2008-08-29 |
JO2525B1 (en) | 2010-03-17 |
TWI358298B (en) | 2012-02-21 |
NO20065022L (no) | 2006-11-03 |
ZA200608356B (en) | 2008-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0509720A (pt) | derivados de 4-alquil- e 4-alcanoil-piperidina substituìda e seu uso como antagonistas de neurocinina | |
TW200604198A (en) | Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists | |
MY142090A (en) | Substituted diaza-spiro-[5.5]-undecane derivatives and their use as neurokinin antagonists | |
US11091478B2 (en) | Apoptosis-inducing agents | |
BRPI0608074A2 (pt) | derivados de oxa-diaza-espiro-[5.5]-undecanona substituìdos e uso como antagonistas da neurocinina do mesmo | |
NO20082000L (no) | Pyrimidinamidforbindelser som PGDS-inhibitorer | |
BRPI0511722A (pt) | 3-amino-1-arilpropilindóis como inibidores da recaptação de monoamina | |
TR201820559T4 (tr) | Azelastin içeren kompozisyonlar ve bunların kullanım metotları. | |
BR0317658A (pt) | Derivados de 1-piperidin-4-il-4-pirrolidin-3-il-piperazina substituìda e seu emprego como antagonistas de neuroquinina | |
CL43596B (es) | Compuestos derivados de pirimidina; composicion farmaceutica; y su uso para tratar o prevenir un trastorno o enfermedad relacionado con la actividad de crth2, tales como asma, rinitis alergica, dermatitis, atopica y conjuntivitis alergica. | |
BR112021022099A2 (pt) | Derivados de amino quinazolina como inibidores de p2x3 | |
NZ591914A (en) | Naphthylacetic acids | |
BR112014013958A2 (pt) | ácidos piperidinila naftilacéticos | |
WO2010091104A8 (en) | Glucosylceramide synthase inhibitors | |
BR112013030264A2 (pt) | ácidos acéticos de benzociclohepteno | |
AR078552A1 (es) | Derivados de feniloxadiazol como agentes inhibidores de las pgds | |
BRPI0411936A (pt) | composto, processo para a sua preparação, composição farmacêutica que comprende o mesmo, utilização de um composto, métodos para o tratamento e profilaxia de distúrbios do sistema nervoso central, alimentares e obesidade | |
EA200800183A1 (ru) | Новые производные индолкарбоксамида, содержащая их фармацевтическая композиция и способ лечения | |
CL2007002349A1 (es) | Compuestos derivados de pirazolo[3,4-b]piridina; composicion farmaceutica; y uso para el tratamiento y/o profilaxis de una enfermedad inflamatoria y/o alergica, tal como epoc, asma y rinitis. | |
EA200701898A1 (ru) | Производные диаза-спиро-[4.4]-нонана в качестве антагонистов нейрокинина (nk1) | |
DE602005022558D1 (de) | Mikroemulsionsformulierungen mit bestimmten substanz p antagonisten | |
MX2021014116A (es) | Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). | |
MY145168A (en) | Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists | |
BR0315762A (pt) | Utilização de derivados de ácidos piperazino-sulfónicos como antagonistas ccr1 para o tratamento de fibrose, doença de alzheimer e outras doenças | |
TH80265B (th) | อนุพันธ์ของ 4-แอลคิล- และ 4-แอลคาโนอิล-ไพเพริดีน ที่ได้รับการแทนที่ และการใช้ของมันเป็นแอนทาโกนิสท์ของนิวโรไคนิน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2204 DE 02/04/2013. |