MX2021014116A - Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). - Google Patents

Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).

Info

Publication number
MX2021014116A
MX2021014116A MX2021014116A MX2021014116A MX2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A
Authority
MX
Mexico
Prior art keywords
compounds
inhibitors
relates
pyridopyrimidines
derivatives
Prior art date
Application number
MX2021014116A
Other languages
English (en)
Inventor
Matteo Biagetti
Roberta Lanaro
Claudio Fiorelli
Paolo Bruno
Charles Baker-Glenn
De Poël Hervè Van
Stephen David Penrose
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MX2021014116A publication Critical patent/MX2021014116A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a compuestos de la fórmula I que inhiben el purinoreceptor 3 de P2X (en lo sucesivo inhibidores de P2X3); la invención se refiere particularmente a compuestos que son derivados de piridopirimidinas, métodos para preparar estos compuestos, composiciones farmacéuticas que los contienen y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles en el tratamiento de muchos trastornos asociados con mecanismos de los receptores P2X3, tales como enfermedades respiratorias que incluyen tos, asma, fibrosis pulmonar idiopática (IPF) y enfermedad pulmonar obstructiva crónica (COPD).
MX2021014116A 2019-05-31 2020-05-28 Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). MX2021014116A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19177610 2019-05-31
EP19201165 2019-10-02
PCT/EP2020/064915 WO2020239953A1 (en) 2019-05-31 2020-05-28 Pyridopyrimidines derivatives as p2x3 inhibitors

Publications (1)

Publication Number Publication Date
MX2021014116A true MX2021014116A (es) 2021-12-10

Family

ID=70857198

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014116A MX2021014116A (es) 2019-05-31 2020-05-28 Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).

Country Status (11)

Country Link
US (1) US20230212169A9 (es)
EP (1) EP3976609A1 (es)
JP (1) JP2022534434A (es)
KR (1) KR20220016074A (es)
CN (1) CN114222741A (es)
AU (1) AU2020281924A1 (es)
BR (1) BR112021020279A2 (es)
CA (1) CA3136024A1 (es)
MA (1) MA56020A (es)
MX (1) MX2021014116A (es)
WO (1) WO2020239953A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022160931A1 (zh) * 2021-01-28 2022-08-04 浙江海正药业股份有限公司 吡啶并嘧啶类衍生物及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4342007B2 (ja) * 1998-08-10 2009-10-14 大日本住友製薬株式会社 キナゾリン誘導体
ES2439454T3 (es) * 2005-09-01 2014-01-23 F. Hoffmann-La Roche Ag Diaminopirimidinas como moduladores de P2X3 y P2X2/3
BR122019017036B8 (pt) 2006-06-29 2021-07-27 Hoffmann La Roche compostos de arilamidas substituídas por tetrazol, usos dos referidos compostos e composição farmacêutica
JP5396379B2 (ja) * 2007-04-02 2014-01-22 エボテック・アーゲー ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用
WO2008130481A1 (en) 2007-04-17 2008-10-30 Renovis, Inc. 2-cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
CA2715835C (en) 2008-02-29 2017-03-21 Renovis, Inc. Amide compounds, compositions and uses thereof
JP5608655B2 (ja) 2008-09-18 2014-10-15 エヴォテック アーゲー Ｐ２ｘ３受容体活性のモジュレーター
WO2011041655A1 (en) * 2009-10-01 2011-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Quinazolin-4-amine derivatives; and methods of use
US8901133B2 (en) * 2010-11-10 2014-12-02 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2016084922A1 (ja) 2014-11-28 2016-06-02 塩野義製薬株式会社 １，２，４－トリアジン誘導体およびその医薬組成物
WO2016088838A1 (ja) 2014-12-04 2016-06-09 塩野義製薬株式会社 プリン誘導体およびその医薬組成物
SI3587417T1 (sl) 2014-12-09 2022-04-29 Bayer Ag 1,3-tiazol-2-il substituirani benzamidi
WO2017011729A1 (en) 2015-07-16 2017-01-19 Patara Pharma, LLC Combination therapies for the treatment of lung diseases
AU2016330466B2 (en) 2015-09-29 2021-01-28 Afferent Pharmaceuticals, Inc. Diaminopyrimidine P2x3 and P2x2/3 receptor modulators for use in the treatment of cough
CA3006300C (en) * 2015-11-25 2024-02-27 Convergene Llc Bicyclic bet bromodomain inhibitors and uses thereof
GB201700814D0 (en) * 2017-01-17 2017-03-01 Liverpool School Tropical Medicine Compounds
EA202190339A1 (ru) * 2018-07-25 2021-05-20 Фаэс Фарма, С.А. Пиридопиримидины в качестве ингибиторов н4-гистаминовых рецепторов

Also Published As

Publication number Publication date
US20230212169A9 (en) 2023-07-06
KR20220016074A (ko) 2022-02-08
MA56020A (fr) 2022-04-06
CA3136024A1 (en) 2020-12-03
JP2022534434A (ja) 2022-07-29
EP3976609A1 (en) 2022-04-06
BR112021020279A2 (pt) 2021-12-14
US20220235060A1 (en) 2022-07-28
AU2020281924A1 (en) 2021-12-16
CN114222741A (zh) 2022-03-22
WO2020239953A1 (en) 2020-12-03

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