MX2021014116A - Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). - Google Patents
Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3).Info
- Publication number
- MX2021014116A MX2021014116A MX2021014116A MX2021014116A MX2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A MX 2021014116 A MX2021014116 A MX 2021014116A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- inhibitors
- relates
- pyridopyrimidines
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de la fórmula I que inhiben el purinoreceptor 3 de P2X (en lo sucesivo inhibidores de P2X3); la invención se refiere particularmente a compuestos que son derivados de piridopirimidinas, métodos para preparar estos compuestos, composiciones farmacéuticas que los contienen y uso terapéutico de los mismos. Los compuestos de la invención pueden ser útiles en el tratamiento de muchos trastornos asociados con mecanismos de los receptores P2X3, tales como enfermedades respiratorias que incluyen tos, asma, fibrosis pulmonar idiopática (IPF) y enfermedad pulmonar obstructiva crónica (COPD).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19177610 | 2019-05-31 | ||
EP19201165 | 2019-10-02 | ||
PCT/EP2020/064915 WO2020239953A1 (en) | 2019-05-31 | 2020-05-28 | Pyridopyrimidines derivatives as p2x3 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021014116A true MX2021014116A (es) | 2021-12-10 |
Family
ID=70857198
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021014116A MX2021014116A (es) | 2019-05-31 | 2020-05-28 | Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230212169A9 (es) |
EP (1) | EP3976609A1 (es) |
JP (1) | JP2022534434A (es) |
KR (1) | KR20220016074A (es) |
CN (1) | CN114222741A (es) |
AU (1) | AU2020281924A1 (es) |
BR (1) | BR112021020279A2 (es) |
CA (1) | CA3136024A1 (es) |
MA (1) | MA56020A (es) |
MX (1) | MX2021014116A (es) |
WO (1) | WO2020239953A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022160931A1 (zh) * | 2021-01-28 | 2022-08-04 | 浙江海正药业股份有限公司 | 吡啶并嘧啶类衍生物及其制备方法和用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4342007B2 (ja) * | 1998-08-10 | 2009-10-14 | 大日本住友製薬株式会社 | キナゾリン誘導体 |
EP1924264B9 (en) * | 2005-09-01 | 2014-02-19 | F.Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
CN103159692B (zh) | 2006-06-29 | 2015-03-18 | 弗·哈夫曼-拉罗切有限公司 | 四唑取代的芳基酰胺类 |
JP5396379B2 (ja) * | 2007-04-02 | 2014-01-22 | エボテック・アーゲー | ピリド−2−イル縮合複素環式化合物ならびにその組成物および使用 |
US8076345B2 (en) | 2007-04-17 | 2011-12-13 | Evotec Ag | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof |
WO2009110985A2 (en) | 2008-02-29 | 2009-09-11 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
CA2737038A1 (en) | 2008-09-18 | 2010-03-25 | Evotec Ag | Amide compounds, compositions and uses thereof |
WO2011041655A1 (en) * | 2009-10-01 | 2011-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Quinazolin-4-amine derivatives; and methods of use |
WO2012064973A2 (en) * | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2016084922A1 (ja) | 2014-11-28 | 2016-06-02 | 塩野義製薬株式会社 | 1,2,4-トリアジン誘導体およびその医薬組成物 |
JPWO2016088838A1 (ja) | 2014-12-04 | 2017-09-14 | 塩野義製薬株式会社 | プリン誘導体およびその医薬組成物 |
KR20230098368A (ko) | 2014-12-09 | 2023-07-03 | 바이엘 악티엔게젤샤프트 | 1,3-티아졸-2-일 치환된 벤즈아미드 |
WO2017011729A1 (en) | 2015-07-16 | 2017-01-19 | Patara Pharma, LLC | Combination therapies for the treatment of lung diseases |
US11260056B2 (en) | 2015-09-29 | 2022-03-01 | Afferent Pharmaceuticals, Inc. | Diaminopyrimidine P2X3 and P2X2/3 receptor modulators for use in the treatment of cough |
WO2017091661A1 (en) * | 2015-11-25 | 2017-06-01 | Strovel Jeffrey William | Bicyclic bet bromodomain inhibitors and uses thereof |
GB201700814D0 (en) * | 2017-01-17 | 2017-03-01 | Liverpool School Tropical Medicine | Compounds |
CA3107556C (en) * | 2018-07-25 | 2022-10-25 | Faes Farma, S.A. | Pyridopyrimidines as histamine h4-receptor inhibitors |
-
2020
- 2020-05-28 EP EP20728500.8A patent/EP3976609A1/en active Pending
- 2020-05-28 WO PCT/EP2020/064915 patent/WO2020239953A1/en unknown
- 2020-05-28 CN CN202080038831.1A patent/CN114222741A/zh active Pending
- 2020-05-28 US US17/615,012 patent/US20230212169A9/en active Pending
- 2020-05-28 BR BR112021020279A patent/BR112021020279A2/pt unknown
- 2020-05-28 KR KR1020217038473A patent/KR20220016074A/ko unknown
- 2020-05-28 JP JP2021571021A patent/JP2022534434A/ja active Pending
- 2020-05-28 MX MX2021014116A patent/MX2021014116A/es unknown
- 2020-05-28 CA CA3136024A patent/CA3136024A1/en active Pending
- 2020-05-28 MA MA056020A patent/MA56020A/fr unknown
- 2020-05-28 AU AU2020281924A patent/AU2020281924A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112021020279A2 (pt) | 2021-12-14 |
JP2022534434A (ja) | 2022-07-29 |
KR20220016074A (ko) | 2022-02-08 |
EP3976609A1 (en) | 2022-04-06 |
WO2020239953A1 (en) | 2020-12-03 |
CA3136024A1 (en) | 2020-12-03 |
MA56020A (fr) | 2022-04-06 |
US20220235060A1 (en) | 2022-07-28 |
CN114222741A (zh) | 2022-03-22 |
AU2020281924A1 (en) | 2021-12-16 |
US20230212169A9 (en) | 2023-07-06 |
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