BR112014013958A2 - ácidos piperidinila naftilacéticos - Google Patents

ácidos piperidinila naftilacéticos

Info

Publication number
BR112014013958A2
BR112014013958A2 BR112014013958A BR112014013958A BR112014013958A2 BR 112014013958 A2 BR112014013958 A2 BR 112014013958A2 BR 112014013958 A BR112014013958 A BR 112014013958A BR 112014013958 A BR112014013958 A BR 112014013958A BR 112014013958 A2 BR112014013958 A2 BR 112014013958A2
Authority
BR
Brazil
Prior art keywords
compounds
piperidinyl
formula
naphthylacetic
acids
Prior art date
Application number
BR112014013958A
Other languages
English (en)
Other versions
BR112014013958A8 (pt
Inventor
Sidduri Achyutharao
Mertz Eric
Firooznia Fariborz
Wright Tilley Jefferson
So Sung-Sau
Lin Tai-An
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112014013958A2 publication Critical patent/BR112014013958A2/pt
Publication of BR112014013958A8 publication Critical patent/BR112014013958A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1/1 resumo ácidos piperidinila naftilacéticos a invenção relaciona-se com os compostos da fórmula (i): oh r3r1 o n r2 x (i) e seus sais farmaceuticamente aceitáveis, em que r1, r2, r3 e x são definidos na descrição detalhada e nas reivindicações. além disso, a presente invenção refere-se aos métodos de manufatura e ao uso dos compostos da fórmula i bem como às composições farmacêuticas que contêm esses compostos. os compostos da fórmula i são antagonistas ou agonistas parciais no receptor crth2 e podem ser de utilidade no tratamento de enfermidades e distúrbios associados com esse receptor, tais como a asma.
BR112014013958A 2011-12-12 2012-12-10 ácidos piperidinila naftilacéticos BR112014013958A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161569313P 2011-12-12 2011-12-12
PCT/EP2012/074882 WO2013087544A1 (en) 2011-12-12 2012-12-10 Piperidinyl naphthylacetic acids

Publications (2)

Publication Number Publication Date
BR112014013958A2 true BR112014013958A2 (pt) 2017-06-13
BR112014013958A8 BR112014013958A8 (pt) 2017-06-13

Family

ID=47427287

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014013958A BR112014013958A8 (pt) 2011-12-12 2012-12-10 ácidos piperidinila naftilacéticos

Country Status (11)

Country Link
US (1) US8691993B2 (pt)
EP (1) EP2791111B1 (pt)
JP (1) JP6154397B2 (pt)
KR (1) KR20140103319A (pt)
CN (1) CN103958468B (pt)
BR (1) BR112014013958A8 (pt)
CA (1) CA2855940A1 (pt)
HK (1) HK1200453A1 (pt)
MX (1) MX350862B (pt)
RU (1) RU2628083C2 (pt)
WO (1) WO2013087544A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2014129613A (ru) 2011-12-21 2016-02-10 Актелион Фармасьютиклз Лтд Гетероциклильные производные и их применение в качестве модуляторов рецептора простагландина d2
CN104428305A (zh) 2012-07-05 2015-03-18 埃科特莱茵药品有限公司 1-苯基-取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途
US9494035B2 (en) 2012-11-06 2016-11-15 Evolution Engineering Inc. Fluid pressure pulse generator and method of using same
US9714569B2 (en) 2012-12-17 2017-07-25 Evolution Engineering Inc. Mud pulse telemetry apparatus with a pressure transducer and method of operating same
US10753201B2 (en) 2012-12-17 2020-08-25 Evolution Engineering Inc. Mud pulse telemetry apparatus with a pressure transducer and method of operating same
CA2895346C (en) 2012-12-17 2018-10-23 Evolution Engineering Inc. Downhole telemetry signal modulation using pressure pulses of multiple pulse heights
CA2895683A1 (en) 2014-06-27 2015-12-27 Evolution Engineering Inc. Fluid pressure pulse generator for a downhole telemetry tool
US9631488B2 (en) 2014-06-27 2017-04-25 Evolution Engineering Inc. Fluid pressure pulse generator for a downhole telemetry tool
CA2895680A1 (en) 2014-06-27 2015-12-27 Evolution Engineering Inc. Fluid pressure pulse generator for a downhole telemetry tool
WO2020006557A1 (en) * 2018-06-29 2020-01-02 Adonia Papathanassiu Compositions and methods of using itaconic acid derivatives

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
MX2007010215A (es) * 2005-02-24 2007-11-07 Millennium Pharm Inc Antagonistas del receptor pgd2 para el tratamiento de enfermedades inflamatorias.
RU2405770C2 (ru) * 2005-09-27 2010-12-10 Сионоги Энд Ко., Лтд. Производное сульфонамида, обладающее антагонистической активностью в отношении рецептора pgd2
AU2007257841A1 (en) * 2006-06-09 2007-12-21 Icos Corporation Substituted phenyl acetic acids as DP-2 antagonists
US20110190336A1 (en) * 2008-10-16 2011-08-04 Cara Therapeutics, Inc. Azabenzimidazolones
US8621184B1 (en) 2008-10-31 2013-12-31 Netapp, Inc. Effective scheduling of producer-consumer processes in a multi-processor system
DK2346819T3 (da) * 2008-11-17 2013-05-13 Hoffmann La Roche Naphthyleddikesyre
WO2010055006A1 (en) * 2008-11-17 2010-05-20 F. Hoffmann-La Roche Ag Naphthylacetic acids used as crth2 antagonists or partial agonists

Also Published As

Publication number Publication date
JP6154397B2 (ja) 2017-06-28
WO2013087544A1 (en) 2013-06-20
CN103958468B (zh) 2017-03-01
US20130150407A1 (en) 2013-06-13
CN103958468A (zh) 2014-07-30
JP2015504863A (ja) 2015-02-16
US8691993B2 (en) 2014-04-08
EP2791111B1 (en) 2017-01-18
BR112014013958A8 (pt) 2017-06-13
RU2014127143A (ru) 2016-02-10
HK1200453A1 (en) 2015-08-07
MX2014006468A (es) 2014-09-01
EP2791111A1 (en) 2014-10-22
MX350862B (es) 2017-09-19
CA2855940A1 (en) 2013-06-20
KR20140103319A (ko) 2014-08-26
RU2628083C2 (ru) 2017-08-14

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]