BR112015012909A2 - compostos de ácido borônico de triazol substituído - Google Patents
compostos de ácido borônico de triazol substituídoInfo
- Publication number
- BR112015012909A2 BR112015012909A2 BR112015012909A BR112015012909A BR112015012909A2 BR 112015012909 A2 BR112015012909 A2 BR 112015012909A2 BR 112015012909 A BR112015012909 A BR 112015012909A BR 112015012909 A BR112015012909 A BR 112015012909A BR 112015012909 A2 BR112015012909 A2 BR 112015012909A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- boronic acid
- substituted triazole
- acid compounds
- formula
- Prior art date
Links
- -1 triazole boronic acid compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1/1 resumo compostos de ácido borônico de triazol substituído a invenção se refere aos compostos da fórmula (i): 2 r oh o b n oh o h n n 1 n n r h r1'r1'' e sais desses aceitos farmaceuticamente. além disso, a presente invenção se refere a métodos de fabricar e usar os compostos da fórmula i bem como composições farmacêuticas que contêm os ditos compostos. os compostos da fórmula i são inibidores de lmp7 e podem ser úteis no tratamento associado com doenças e distúrbios inflamatórios tais como, por exemplo, artrite reumatóide, lúpus e doença de intestino irritável.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261732459P | 2012-12-03 | 2012-12-03 | |
| PCT/EP2013/075031 WO2014086664A1 (en) | 2012-12-03 | 2013-11-29 | Substituted triazole boronic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015012909A2 true BR112015012909A2 (pt) | 2017-07-11 |
Family
ID=49679525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015012909A BR112015012909A2 (pt) | 2012-12-03 | 2013-11-29 | compostos de ácido borônico de triazol substituído |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9464098B2 (pt) |
| EP (1) | EP2925765B1 (pt) |
| JP (1) | JP6018319B2 (pt) |
| KR (1) | KR101782235B1 (pt) |
| CN (1) | CN104822689B (pt) |
| BR (1) | BR112015012909A2 (pt) |
| CA (1) | CA2893460C (pt) |
| ES (1) | ES2615744T3 (pt) |
| HK (1) | HK1212992A1 (pt) |
| MX (1) | MX2015006715A (pt) |
| RU (1) | RU2625801C2 (pt) |
| WO (1) | WO2014086664A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102147420B1 (ko) | 2012-12-07 | 2020-08-25 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| US9403850B2 (en) | 2013-01-10 | 2016-08-02 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| WO2014151958A1 (en) | 2013-03-14 | 2014-09-25 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| KR20220065084A (ko) | 2014-06-11 | 2022-05-19 | 베나토알엑스 파마슈티컬스, 인크. | 베타-락타마제 억제제 |
| US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| BR112017006349A2 (pt) * | 2014-10-01 | 2017-12-12 | Merck Patent Gmbh | derivados de ácido borônico |
| US10399996B2 (en) * | 2015-09-11 | 2019-09-03 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN107151254A (zh) * | 2016-03-06 | 2017-09-12 | 复旦大学 | 一种作为20s蛋白酶体抑制剂的硼酸类化合物及其制备方法 |
| CN107151255A (zh) * | 2016-03-06 | 2017-09-12 | 复旦大学 | 硼酸类化合物及其制备方法和用途 |
| EP3494121B1 (en) | 2016-08-04 | 2021-10-06 | Venatorx Pharmaceuticals, Inc. | Boron-containing compounds |
| CN110959008A (zh) | 2017-05-26 | 2020-04-03 | 维纳拓尔斯制药公司 | 青霉素结合蛋白抑制剂 |
| EP3630783A4 (en) | 2017-05-26 | 2021-03-03 | Venatorx Pharmaceuticals, Inc. | PENICILLIN BINDING PROTEIN INHIBITORS |
| EP3672977B1 (en) | 2017-08-24 | 2022-06-22 | Merck Patent GmbH | Boronic acid derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150010802A (ko) * | 2007-08-06 | 2015-01-28 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아좀 억제제 |
| EP2180788B1 (en) | 2007-08-10 | 2016-12-21 | Basil Rigas | Anti-inflammatory compounds and uses thereof |
| TW201000107A (en) * | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
| AR075090A1 (es) * | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| US9365612B2 (en) * | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
| MX2012010017A (es) * | 2010-03-01 | 2012-10-01 | Onyx Therapeutics Inc | Compuestos de para la inhibicion de inmunoproteasomas. |
| WO2012078540A1 (en) * | 2010-12-08 | 2012-06-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulating immune cell activity using cytokine-induced src homology 2 and/or high temperature requirement a-1 |
| EP2793900B1 (en) | 2011-12-22 | 2018-08-22 | Ares Trading S.A. | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
-
2013
- 2013-11-29 ES ES13798328.4T patent/ES2615744T3/es active Active
- 2013-11-29 US US14/646,782 patent/US9464098B2/en not_active Expired - Fee Related
- 2013-11-29 MX MX2015006715A patent/MX2015006715A/es unknown
- 2013-11-29 WO PCT/EP2013/075031 patent/WO2014086664A1/en active Application Filing
- 2013-11-29 EP EP13798328.4A patent/EP2925765B1/en not_active Not-in-force
- 2013-11-29 BR BR112015012909A patent/BR112015012909A2/pt not_active Application Discontinuation
- 2013-11-29 RU RU2015123499A patent/RU2625801C2/ru not_active IP Right Cessation
- 2013-11-29 CA CA2893460A patent/CA2893460C/en not_active Expired - Fee Related
- 2013-11-29 CN CN201380062752.4A patent/CN104822689B/zh not_active Expired - Fee Related
- 2013-11-29 KR KR1020157017722A patent/KR101782235B1/ko active IP Right Grant
- 2013-11-29 JP JP2015545745A patent/JP6018319B2/ja not_active Expired - Fee Related
-
2016
- 2016-01-26 HK HK16100857.4A patent/HK1212992A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2925765A1 (en) | 2015-10-07 |
| CA2893460A1 (en) | 2014-06-12 |
| CN104822689B (zh) | 2016-11-02 |
| CN104822689A (zh) | 2015-08-05 |
| KR20150090248A (ko) | 2015-08-05 |
| JP6018319B2 (ja) | 2016-11-02 |
| HK1212992A1 (zh) | 2016-06-24 |
| US9464098B2 (en) | 2016-10-11 |
| EP2925765B1 (en) | 2016-12-14 |
| US20150329565A1 (en) | 2015-11-19 |
| JP2016502546A (ja) | 2016-01-28 |
| WO2014086664A1 (en) | 2014-06-12 |
| KR101782235B1 (ko) | 2017-09-26 |
| RU2015123499A (ru) | 2017-01-13 |
| RU2625801C2 (ru) | 2017-07-19 |
| MX2015006715A (es) | 2015-08-14 |
| CA2893460C (en) | 2018-01-09 |
| ES2615744T3 (es) | 2017-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015012909A2 (pt) | compostos de ácido borônico de triazol substituído | |
| BR112014001801A2 (pt) | indazóis | |
| BR112017013806A2 (pt) | composto, composição farmacêutica, utilização e processo para a fabricação de um composto | |
| BR112015014701A2 (pt) | derivados de benzimidazol como inibidores de quinase | |
| BR112014030674A2 (pt) | compostos n-ariltriazol como antagonistas do lpar | |
| BR112015028501A2 (pt) | derivados de bipirazol como inibidores de jak | |
| UA113051C2 (xx) | Гетероциклічні похідні та їх застосування у лікуванні неврологічних розладів | |
| BR112013021537A2 (pt) | derivados de tiazolilpenil-benzenosulfonamido como inibidores da quinase | |
| BR112014030685A2 (pt) | compostos de n-alquiltriazol como antagonistas de lpar | |
| BRPI0911035B8 (pt) | ativadores de pirrolidinona glicoquinase | |
| BR112014004219A2 (pt) | pirano[3,2-d][1,3]tiazol como inibidores de glicosidase | |
| PL415078A1 (pl) | Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków | |
| BR112015006737A2 (pt) | compostos de sulfonamida substituídos | |
| UA111770C2 (uk) | Інгібітори бромдомену | |
| BR112013000750A2 (pt) | 1-hidroxiimino-3-fenil-propanos | |
| BR112013000920A2 (pt) | compostos para a redução de produção de beta-amiloide | |
| BR112013002957A2 (pt) | composto de 1,4,5,6-tetrahidro-pirimidin-2-ilamina | |
| GEP20146146B (en) | Pyrrolopyrimidine compounds as inhibitors of cdk4/6 | |
| BR112014018959A8 (pt) | Compostos, composições farmacêuticas, utilizações de um composto e métodos para o tratamento do câncer | |
| NZ601121A (en) | 5-alkynyl-pyrimidines | |
| BR112014005226A2 (pt) | derivados de benzonitrila como inibidores de cinase | |
| BR112012027062B8 (pt) | composto, processo para a preparação de um composto e usos do mesmo | |
| BR112013030264A2 (pt) | ácidos acéticos de benzociclohepteno | |
| BR112012012947A2 (pt) | forma cristalina e amorfa de hemitartarato genz 112638 como inibidor de glicosilceramida sintase | |
| EA201270492A1 (ru) | Соединения для лечения дислипидемии и связанных с ней заболеваний |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law | ||
| B07E | Notice of approval relating to section 229 industrial property law |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: suspension of the patent application procedure | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |