BR112013000750A2 - 1-hidroxiimino-3-fenil-propanos - Google Patents

1-hidroxiimino-3-fenil-propanos

Info

Publication number
BR112013000750A2
BR112013000750A2 BR112013000750A BR112013000750A BR112013000750A2 BR 112013000750 A2 BR112013000750 A2 BR 112013000750A2 BR 112013000750 A BR112013000750 A BR 112013000750A BR 112013000750 A BR112013000750 A BR 112013000750A BR 112013000750 A2 BR112013000750 A2 BR 112013000750A2
Authority
BR
Brazil
Prior art keywords
phenylpropanes
hydroxyimino
hydroxylimino
medicines
diabetes
Prior art date
Application number
BR112013000750A
Other languages
English (en)
Other versions
BR112013000750B1 (pt
Inventor
Caterina Bissantz
Christoph Ullmer
Hans Richter
Henrietta Dehmlow
Kyungjin Kim
Patrizio Mattei
Rainer E Martin
Shawn David Erickson
Sherrie Lynn Pietranico-Cole
Ulrike Obst Sander
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR112013000750A2 publication Critical patent/BR112013000750A2/pt
Publication of BR112013000750B1 publication Critical patent/BR112013000750B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/48—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Organic Chemistry (AREA)
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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-hidroxiimino-3-fenil-propanos. essa invenção se refere aos novos 1-hidroxilimino-3-fenil-propanos da fórmular: onde r~1~ a r~10~ são como definidos na descrição e nas reivindicações, bem como os sais farmaceuticamente aceitáveis dos mesmos. esses compostos são agonistas de gpbar1 e podem ser usados como medicamentos para o tratamento de doenças, tais como diabetes do tipo ii.
BR112013000750-8A 2010-07-12 2011-07-08 1-hidroxiimino-3-fenil-propanos BR112013000750B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10169293.7 2010-07-12
EP10169293 2010-07-12
PCT/EP2011/061577 WO2012007365A1 (en) 2010-07-12 2011-07-08 1-hydroxyimino-3-phenyl-propanes

Publications (2)

Publication Number Publication Date
BR112013000750A2 true BR112013000750A2 (pt) 2016-05-31
BR112013000750B1 BR112013000750B1 (pt) 2021-11-03

Family

ID=43734233

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Application Number Title Priority Date Filing Date
BR112013000750-8A BR112013000750B1 (pt) 2010-07-12 2011-07-08 1-hidroxiimino-3-fenil-propanos

Country Status (14)

Country Link
US (1) US8765730B2 (pt)
EP (1) EP2593426B1 (pt)
JP (1) JP5593445B2 (pt)
KR (1) KR101469395B1 (pt)
CN (1) CN103153945B (pt)
AR (1) AR082138A1 (pt)
BR (1) BR112013000750B1 (pt)
CA (1) CA2802313C (pt)
ES (1) ES2516165T3 (pt)
HK (1) HK1181747A1 (pt)
MX (1) MX2013000391A (pt)
RU (1) RU2579114C9 (pt)
TW (1) TW201206436A (pt)
WO (1) WO2012007365A1 (pt)

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CA2807538A1 (en) 2010-08-10 2012-02-16 Abbvie Inc. Novel trpv3 modulators
US9012651B2 (en) 2011-03-24 2015-04-21 Abbvie Inc. TRPV3 modulators
WO2013062966A2 (en) 2011-10-24 2013-05-02 Abbvie Inc. Novel trpv3 modulators
WO2013060653A1 (en) * 2011-10-26 2013-05-02 F. Hoffmann-La Roche Ag 1-cycloalkyl- or 1-heterocyclyl-hydroxyimino-3-phenyl-propanes
RU2014122487A (ru) * 2011-11-14 2015-12-27 Ф. Хоффманн-Ля Рош Аг 1-пиридазинил-гидроксиимино-3-фенил-пропаны в качестве агонистов сопряженного с g-белком рецептора желчных кислот gpbar1
JP5871073B2 (ja) 2012-08-07 2016-03-01 株式会社村田製作所 圧電発電装置
JP2016522800A (ja) 2013-04-12 2016-08-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 新規トリアゾリンチオン誘導体
US9822099B2 (en) 2013-04-12 2017-11-21 Bayer Cropscience Aktiengesellschaft Triazole derivatives
CN105283450B (zh) 2013-04-12 2018-12-18 拜耳作物科学股份公司 三唑衍生物
EA201792151A1 (ru) 2015-04-02 2018-04-30 Байер Кропсайенс Акциенгезельшафт Новые 5-замещенные производные имидазола
EP3277674B1 (en) 2015-04-02 2019-09-11 Bayer CropScience Aktiengesellschaft Triazol derivatives as fungicides
EA201990690A1 (ru) 2016-09-13 2019-10-31 Комбинации активных соединений, содержащие производное 5-замещенного имидазола
CN109983000A (zh) 2016-09-29 2019-07-05 拜耳作物科学股份公司 新的5-取代的咪唑基甲基衍生物
US20200045972A1 (en) 2016-09-29 2020-02-13 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazolylmethyl derivatives
EP3519392A1 (en) 2016-09-29 2019-08-07 Bayer CropScience Aktiengesellschaft Novel 5-substituted imidazole derivatives
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RU2013103538A (ru) 2014-08-20
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TW201206436A (en) 2012-02-16
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US8765730B2 (en) 2014-07-01
HK1181747A1 (zh) 2013-11-15
AR082138A1 (es) 2012-11-14
BR112013000750B1 (pt) 2021-11-03
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CA2802313C (en) 2019-01-15
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