BRPI0911035B8 - ativadores de pirrolidinona glicoquinase - Google Patents
ativadores de pirrolidinona glicoquinaseInfo
- Publication number
- BRPI0911035B8 BRPI0911035B8 BRPI0911035A BRPI0911035A BRPI0911035B8 BR PI0911035 B8 BRPI0911035 B8 BR PI0911035B8 BR PI0911035 A BRPI0911035 A BR PI0911035A BR PI0911035 A BRPI0911035 A BR PI0911035A BR PI0911035 B8 BRPI0911035 B8 BR PI0911035B8
- Authority
- BR
- Brazil
- Prior art keywords
- pyrrolidinone
- glycokinase activators
- glycokinase
- activators
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4537008P | 2008-04-16 | 2008-04-16 | |
US61/045,370 | 2008-04-16 | ||
US14576109P | 2009-01-20 | 2009-01-20 | |
US61/145,761 | 2009-01-20 | ||
PCT/EP2009/054067 WO2009127546A1 (en) | 2008-04-16 | 2009-04-06 | Pyrrolidinone glucokinase activators |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0911035A2 BRPI0911035A2 (pt) | 2019-07-16 |
BRPI0911035B1 BRPI0911035B1 (pt) | 2021-03-02 |
BRPI0911035B8 true BRPI0911035B8 (pt) | 2021-05-25 |
Family
ID=40785354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0911035A BRPI0911035B8 (pt) | 2008-04-16 | 2009-04-06 | ativadores de pirrolidinona glicoquinase |
Country Status (25)
Country | Link |
---|---|
US (1) | US7741327B2 (pt) |
EP (1) | EP2274297B1 (pt) |
JP (1) | JP5518838B2 (pt) |
KR (1) | KR101259249B1 (pt) |
CN (1) | CN102007118B (pt) |
AR (1) | AR071474A1 (pt) |
AT (1) | ATE557017T1 (pt) |
AU (1) | AU2009237794B2 (pt) |
BR (1) | BRPI0911035B8 (pt) |
CA (1) | CA2720524C (pt) |
CL (1) | CL2009000889A1 (pt) |
CY (1) | CY1112921T1 (pt) |
DK (1) | DK2274297T3 (pt) |
ES (1) | ES2386192T3 (pt) |
HR (1) | HRP20120589T1 (pt) |
IL (1) | IL207503A (pt) |
MX (1) | MX2010011226A (pt) |
PE (1) | PE20091842A1 (pt) |
PL (1) | PL2274297T3 (pt) |
PT (1) | PT2274297E (pt) |
RU (1) | RU2010146384A (pt) |
SI (1) | SI2274297T1 (pt) |
TW (1) | TW200944519A (pt) |
WO (1) | WO2009127546A1 (pt) |
ZA (1) | ZA201006159B (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110021570A1 (en) * | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
CN102959076B (zh) | 2010-03-31 | 2015-09-16 | 斯克里普斯研究所 | 重编程细胞 |
US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
US20120142705A1 (en) * | 2010-12-06 | 2012-06-07 | Robert Francis Kester | Isatin and oxindole compounds |
US8470866B2 (en) * | 2011-05-03 | 2013-06-25 | Hoffmann-La Roche Inc. | Isoindolinone derivatives |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
JP6297590B2 (ja) * | 2012-12-25 | 2018-03-20 | ファ・メディシンHua Medicine | 1−([1,3]ジオキソラン−4−イルメチル)−1h−ピラゾール−3−イルアミンを調製するための方法 |
US10604541B2 (en) | 2016-07-22 | 2020-03-31 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
EP3556354A4 (en) * | 2016-12-15 | 2020-07-01 | Hua Medicine (Shanghai) Ltd. | ORAL PRODUCTION OF A GLUCOKINASE ACTIVATOR AND PRODUCTION METHOD THEREFOR |
US20200095241A1 (en) | 2016-12-22 | 2020-03-26 | Bayer Cropscience Aktiengesellschaft | Substituted 1,2,4-thiadiazolylpyrrolones and 1,2,4-thiadiazolylhydantoins and salts thereof and use thereof as herbicides |
US20200079765A1 (en) | 2016-12-22 | 2020-03-12 | Bayer Cropscience Aktiengesellschaft | Substituted heteroaryl pyrrolones and salts thereof and use thereof as herbicidal active substances |
AU2018391579A1 (en) | 2017-12-19 | 2020-08-06 | Bayer Aktiengesellschaft | Substituted N-heterocyclyl- and N-heteroaryl-tetrahydropyrimidinones and the salts thereof, and the use of same as herbicidal active substances |
AU2019278016A1 (en) * | 2018-05-31 | 2021-01-21 | Hua Medicine (Shanghai) Ltd. | Pharmaceutical combination, composition and combination formulation comprising glucokinase activator and DPP‐IV inhibitor, and preparation method and use thereof |
AU2020443475A1 (en) * | 2020-04-22 | 2022-11-17 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
US11813274B2 (en) | 2020-04-22 | 2023-11-14 | Hua Medicine (Shanghai) Ltd. | Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor |
CN114712488B (zh) * | 2021-01-04 | 2023-12-26 | 华领医药技术(上海)有限公司 | Dorzagliatin和胰高血糖素样肽-1类似物的药物组合物 |
CN113527265B9 (zh) * | 2021-02-02 | 2022-07-19 | 湖南南新制药股份有限公司 | 一种氘代吡咯烷酮衍生物、药物组合物及其用途 |
CN113750100B (zh) * | 2021-08-31 | 2022-12-30 | 海南中济医药科技有限公司 | 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法 |
AR127064A1 (es) | 2021-09-15 | 2023-12-13 | Hua Medicine Shanghai Ltd | Prodroga de derivados de pirrolidona como activador de glucoquinasa |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE842346C (de) | 1950-10-14 | 1952-06-26 | Joachim Dipl-Chem Dr Goerdeler | Verfahren zur Darstellung von 5-Amino-1, 2, 4-thiodiazolen |
DK496784A (da) | 1983-10-18 | 1985-04-19 | Du Pont | 8-substituerede pyrazolopentathiepiner og dermed beslaegtede forbindelser |
JPS6284064A (ja) | 1985-10-09 | 1987-04-17 | Shionogi & Co Ltd | 3−パ−フルオロアルキル−5−ヒドロキシイソオキサゾ−ル類 |
CH668422A5 (de) | 1986-06-26 | 1988-12-30 | Lonza Ag | 4-benzyloxy-3-pyrrolin-2-on, dessen herstellung und verwendung zur synthese von tetramsaeure. |
GB9103454D0 (en) | 1991-02-19 | 1991-04-03 | Pfizer Ltd | Therapeutic agents |
IL116507A (en) | 1991-11-13 | 1997-08-14 | Schering Ag | Pyrazole derivatives |
US5498190A (en) | 1994-06-27 | 1996-03-12 | Handsontoys, Inc. | Flexible foam construction toy and method of manufacturing same |
JPH08151386A (ja) | 1994-09-27 | 1996-06-11 | Takeda Chem Ind Ltd | 複素環エチルチオセフェム化合物、その製造法および抗菌組成物 |
US6114541A (en) | 1997-03-10 | 2000-09-05 | Hoffmann-La Roche Inc. | Method for the preparation of α-Bromo-Lactam derivatives |
DE69910762T2 (de) | 1998-04-30 | 2004-03-11 | Agouron Pharmaceuticals, Inc., La Jolla | Antipicornavirale verbindungen, deren herstellung und verwendung |
GB9812523D0 (en) | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
RU2242469C2 (ru) * | 1999-03-29 | 2004-12-20 | Ф.Хоффманн-Ля Рош Аг | Активаторы глюкокиназы |
DK1169312T3 (da) | 1999-03-29 | 2005-01-31 | Hoffmann La Roche | Glucokinaseaktivatorer |
US6610846B1 (en) | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
ATE250053T1 (de) | 1999-07-15 | 2003-10-15 | Pharmacopeia Inc | Bradikinin b1 rezeptor antagonisten |
GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
BR0110573A (pt) | 2000-05-03 | 2003-04-01 | Hoffmann La Roche | Composto, composição farmacêutica que compreende esse composto, processo para a preparação de uma composição farmacêutica, utilização do composto e processo para o tratamento profilático ou terapêutico e para a preparação do composto |
ES2230309T3 (es) | 2000-05-08 | 2005-05-01 | F. Hoffmann-La Roche Ag | Fenilacetamidas sustituidas y su empleo con ativadores de qucokinasa. |
AU2001265914B2 (en) | 2000-05-08 | 2005-11-03 | F. Hoffmann-La Roche Ag | Para-amine substituted phenylamide glucokinase activators |
BR0115999A (pt) | 2000-12-06 | 2003-09-30 | Hoffmann La Roche | Composto, composição farmacêutica que compreende o mesmo, sua utilização, processo para o tratamento profilático ou terapêutico de diabetes do tipo ii e processo para a preparação do composto |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
DE60309856T2 (de) * | 2002-04-26 | 2007-06-14 | F. Hoffmann-La Roche Ag | Substituierte phenylacetamide und deren verwendung als glucokinaseaktivatoren |
BR0312023A (pt) | 2002-06-27 | 2005-03-22 | Novo Nordisk As | Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica |
CN101805358A (zh) | 2002-10-03 | 2010-08-18 | 诺瓦提斯公司 | 作为葡糖激酶激活剂、可用于治疗ⅱ型糖尿病的取代的(噻唑-2-基)酰胺或磺酰胺 |
AU2003287038A1 (en) | 2002-10-09 | 2004-05-04 | The Board Of Trustees Of The University Of Illinois | METHOD OF PREPARING (3R, 3aS, 6aR) -3- HYDROXYHEXAHYDROFURO (2, 3-b) FURAN AND RELATED COMPOUNDS |
US7132425B2 (en) * | 2002-12-12 | 2006-11-07 | Hoffmann-La Roche Inc. | 5-substituted-six-membered heteroaromatic glucokinase activators |
PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
EP1594863A1 (en) | 2003-02-11 | 2005-11-16 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
NZ540791A (en) | 2003-02-13 | 2009-09-25 | Banyu Pharma Co Ltd | Novel 2-pyridinecarboxamide derivatives |
CN101712657A (zh) | 2003-02-26 | 2010-05-26 | 万有制药株式会社 | 杂芳基氨基甲酰基苯衍生物 |
CA2547591C (en) | 2003-10-24 | 2010-08-17 | Aventis Pharmaceuticals Inc. | Novel compounds and compositions as cathepsin inhibitors |
MXPA06004647A (es) | 2003-10-27 | 2006-06-27 | Merck & Co Inc | Sal antagonista de ccr-2. |
WO2005066145A1 (en) | 2004-01-06 | 2005-07-21 | Novo Nordisk A/S | Heteroaryl-ureas and their use as glucokinase activators |
AU2005214137B2 (en) | 2004-02-18 | 2008-05-29 | Astrazeneca Ab | Compounds |
AU2005214132B9 (en) | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
EP1734040A4 (en) | 2004-03-23 | 2007-11-28 | Banyu Pharma Co Ltd | SUBSTITUTED CHINAZOLINE OR PYRIDOPYRIMIDINE DERIVATIVE |
CN101098876A (zh) | 2004-04-02 | 2008-01-02 | 诺瓦提斯公司 | 噻唑并吡啶衍生物、包含它们的药物形式以及治疗葡糖激酶介导的病症的方法 |
BRPI0509573A (pt) | 2004-04-02 | 2007-09-25 | Novartis Ag | derivados de sulfonamida-tiazolpiridina como ativadores de glicocinase úteis para o tratamento de diabetes do tipo 2 |
BRPI0510163A (pt) | 2004-04-21 | 2007-10-02 | Prosidion Ltd | compostos de amidas tri(ciclo)-substituìdas |
TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0418058D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Fluorination process |
GB0418046D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
BRPI0514147A (pt) | 2004-08-12 | 2008-05-27 | Prosidion Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratamento profilático ou terapêutico de uma condição onde a ativação de gk é desejável, de tratamento profilático ou terapêutico da hiperglicemia ou diabete e de prevenção da diabete em um ser humano que demosntra hiperglicemia pré-diabética ou toleráncia à glicose prejudicada, e, processo para a preparação do composto |
WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
GB0423044D0 (en) | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
WO2006058923A1 (en) | 2004-12-03 | 2006-06-08 | Novo Nordisk A/S | Heteroaromatic glucokinase activators |
WO2006064286A1 (en) | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
WO2006094770A2 (en) | 2005-03-08 | 2006-09-14 | Ludwig-Maximilians-Universitaet Muenchen | Apparatus and method for the final processing of a forming tool for a sheet-metal body part |
TW200714597A (en) | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
JP2009500377A (ja) | 2005-07-08 | 2009-01-08 | ノボ・ノルデイスク・エー/エス | ジシクロアルキルウレア型グルコキナーゼ活性化剤 |
EP2027113A1 (en) | 2005-07-09 | 2009-02-25 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
JP2009500442A (ja) | 2005-07-09 | 2009-01-08 | アストラゼネカ アクチボラグ | 2型糖尿病を処置するためのグルコキナーゼのモジュレーターとしての2−ヘテロシクリルオキシベンゾイルアミノヘテロシクリル化合物 |
NZ575513A (en) | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
AR057661A1 (es) | 2005-07-11 | 2007-12-12 | Tanabe Seiyaku Co | Un derivado de oxima y sus preparaciones |
WO2007006814A1 (en) | 2005-07-14 | 2007-01-18 | Novo Nordisk A/S | Urea glucokinase activators |
WO2007017649A1 (en) | 2005-08-09 | 2007-02-15 | Astrazeneca Ab | Heteroarylcarbamoylbenzene derivatives for the treatment of diabetes |
WO2007026761A1 (ja) | 2005-08-31 | 2007-03-08 | Astellas Pharma Inc. | チアゾール誘導体 |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
CA2627892A1 (en) | 2005-11-01 | 2007-05-10 | Janssen Pharmaceutica N.V. | Substituted dihydroisoindolones as allosteric modulators of glucokinase |
CA2628486A1 (en) | 2005-11-03 | 2007-05-10 | Prosidion Ltd. | Tricyclo substituted amides |
JP2009514835A (ja) | 2005-11-03 | 2009-04-09 | プロシディオン・リミテッド | トリシクロ置換型アミド |
US20080293741A1 (en) | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
TWI411607B (zh) | 2005-11-14 | 2013-10-11 | Vitae Pharmaceuticals Inc | 天門冬胺酸蛋白酶抑制劑 |
EP1948614A2 (en) | 2005-11-18 | 2008-07-30 | Takeda San Diego, Inc. | Glucokinase activators |
CN101437512A (zh) | 2006-01-27 | 2009-05-20 | 阿雷生物药品公司 | 葡萄糖激酶活化剂 |
WO2007104034A2 (en) | 2006-03-08 | 2007-09-13 | Takeda San Diego, Inc. | Glucokinase activators |
NZ571997A (en) | 2006-03-24 | 2011-08-26 | Array Biopharma Inc | 2 -aminopyridine analogs as glucokinase activators |
WO2007115968A2 (en) | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Process for the preparation of a glucokinase activator |
EP2463283B1 (en) | 2006-04-20 | 2014-06-11 | Pfizer Products Inc. | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases |
EP2019824A2 (en) | 2006-04-28 | 2009-02-04 | Transtech Pharma, Inc. | Benzamide glucokinase activators |
US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
MX2009000688A (es) | 2006-07-24 | 2009-01-30 | Hoffmann La Roche | Pirazoles como activadores de glucocinasa. |
EP2049103A2 (en) * | 2006-07-26 | 2009-04-22 | Novartis AG | Inhibitors of undecaprenyl pyrophosphate synthase |
EP2116533B1 (en) | 2007-03-07 | 2013-07-10 | Kyorin Pharmaceutical Co., Ltd. | Glucokinase activator |
WO2008132142A2 (en) | 2007-04-27 | 2008-11-06 | Ucb Pharma S.A. | New heterocyclic derivatives useful for the treatment of cns disorders |
CN101121688A (zh) | 2007-09-14 | 2008-02-13 | 南开大学 | 合成奥拉西坦的改进方法 |
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2009
- 2009-03-09 US US12/400,065 patent/US7741327B2/en active Active
- 2009-04-06 BR BRPI0911035A patent/BRPI0911035B8/pt active IP Right Grant
- 2009-04-06 MX MX2010011226A patent/MX2010011226A/es active IP Right Grant
- 2009-04-06 CA CA2720524A patent/CA2720524C/en active Active
- 2009-04-06 PT PT09732665T patent/PT2274297E/pt unknown
- 2009-04-06 DK DK09732665.6T patent/DK2274297T3/da active
- 2009-04-06 EP EP09732665A patent/EP2274297B1/en active Active
- 2009-04-06 SI SI200930274T patent/SI2274297T1/sl unknown
- 2009-04-06 ES ES09732665T patent/ES2386192T3/es active Active
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