CL2009000889A1 - Compuestos derivados de 2-oxo-2,5-dihidro pirrol propionamida, activadores de glucoquinasa; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compestos; y su uso en el tratamiento de diabetes mellitus. - Google Patents

Compuestos derivados de 2-oxo-2,5-dihidro pirrol propionamida, activadores de glucoquinasa; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compestos; y su uso en el tratamiento de diabetes mellitus.

Info

Publication number
CL2009000889A1
CL2009000889A1 CL2009000889A CL2009000889A CL2009000889A1 CL 2009000889 A1 CL2009000889 A1 CL 2009000889A1 CL 2009000889 A CL2009000889 A CL 2009000889A CL 2009000889 A CL2009000889 A CL 2009000889A CL 2009000889 A1 CL2009000889 A1 CL 2009000889A1
Authority
CL
Chile
Prior art keywords
compounds
oxo
treatment
pharmaceutical composition
propionamide
Prior art date
Application number
CL2009000889A
Other languages
English (en)
Inventor
Joseph Berthel Steven
A Brinkman John
Hayden Stuart
Haynes Nancy-Ellen
Francis Kester Robert
Apostle Mcdermott Lee
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2009000889A1 publication Critical patent/CL2009000889A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Compuestos derivados de 2-oxo-2,5-dihidro-pirrol-propionamida sustituidos, procedimiento de preparación, composición farmacéutica, útil para el tratamiento de la diabetes mellitus.
CL2009000889A 2008-04-16 2009-04-14 Compuestos derivados de 2-oxo-2,5-dihidro pirrol propionamida, activadores de glucoquinasa; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compestos; y su uso en el tratamiento de diabetes mellitus. CL2009000889A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4537008P 2008-04-16 2008-04-16
US14576109P 2009-01-20 2009-01-20

Publications (1)

Publication Number Publication Date
CL2009000889A1 true CL2009000889A1 (es) 2010-07-19

Family

ID=40785354

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000889A CL2009000889A1 (es) 2008-04-16 2009-04-14 Compuestos derivados de 2-oxo-2,5-dihidro pirrol propionamida, activadores de glucoquinasa; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compestos; y su uso en el tratamiento de diabetes mellitus.

Country Status (25)

Country Link
US (1) US7741327B2 (es)
EP (1) EP2274297B1 (es)
JP (1) JP5518838B2 (es)
KR (1) KR101259249B1 (es)
CN (1) CN102007118B (es)
AR (1) AR071474A1 (es)
AT (1) ATE557017T1 (es)
AU (1) AU2009237794B2 (es)
BR (1) BRPI0911035B8 (es)
CA (1) CA2720524C (es)
CL (1) CL2009000889A1 (es)
CY (1) CY1112921T1 (es)
DK (1) DK2274297T3 (es)
ES (1) ES2386192T3 (es)
HR (1) HRP20120589T1 (es)
IL (1) IL207503A (es)
MX (1) MX2010011226A (es)
PE (1) PE20091842A1 (es)
PL (1) PL2274297T3 (es)
PT (1) PT2274297E (es)
RU (1) RU2010146384A (es)
SI (1) SI2274297T1 (es)
TW (1) TW200944519A (es)
WO (1) WO2009127546A1 (es)
ZA (1) ZA201006159B (es)

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WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
NZ709362A (en) * 2012-12-25 2019-07-26 Hua Medicine Process for the preparation of 1-([1,3]dioxolan-4-ylmethyl)-1h-pyrazol-3-ylamine
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AU2017376544C1 (en) * 2016-12-15 2021-06-24 Hua Medicine (Shanghai) Ltd. Oral preparation of glucokinase activator and preparation method therefor
EA201991548A1 (ru) 2016-12-22 2020-01-17 Байер Кропсайенс Акциенгезельшафт Замещенные гетероарилпирролоны, а также их соли, и их применение в качестве гербицидных действующих веществ
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EP3811939A4 (en) * 2018-05-31 2022-05-25 Hua Medicine (Shanghai) Ltd. PHARMACEUTICAL COMBINATION, COMPOSITION AND FORMULATION CONTAINING A GLUCOSIDASE ACTIVATOR AND A &X3B1;-GLUCOSIDASE INHIBITOR, METHODS OF PREPARING THEM AND USES THEREOF
US11813274B2 (en) 2020-04-22 2023-11-14 Hua Medicine (Shanghai) Ltd. Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor
AU2020443475A1 (en) * 2020-04-22 2022-11-17 Hua Medicine (Shanghai) Ltd. Treating untreated or treatment-resistant diabetes with glucokinase activator and sodium-glucose cotransporter-2 inhibitor
WO2022144021A1 (zh) * 2021-01-04 2022-07-07 华领医药技术（上海）有限公司 Dorzagliatin和胰高血糖素样肽-1类似物的药物组合物
CN113527265B9 (zh) * 2021-02-02 2022-07-19 湖南南新制药股份有限公司 一种氘代吡咯烷酮衍生物、药物组合物及其用途
CN113750100B (zh) * 2021-08-31 2022-12-30 海南中济医药科技有限公司 一种含有多扎格列艾汀与西格列汀的药物组合物及其制备方法
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BRPI0911035A2 (pt) 2019-07-16
HRP20120589T1 (hr) 2012-08-31
CA2720524A1 (en) 2009-10-22
WO2009127546A1 (en) 2009-10-22
CN102007118B (zh) 2014-12-31
JP5518838B2 (ja) 2014-06-11
CY1112921T1 (el) 2016-04-13
SI2274297T1 (sl) 2012-08-31
CA2720524C (en) 2016-07-12
IL207503A (en) 2014-03-31
TW200944519A (en) 2009-11-01
AU2009237794B2 (en) 2014-07-10
BRPI0911035B1 (pt) 2021-03-02
US7741327B2 (en) 2010-06-22
KR20100123912A (ko) 2010-11-25
PE20091842A1 (es) 2009-12-04
ES2386192T3 (es) 2012-08-13
PL2274297T3 (pl) 2012-10-31
MX2010011226A (es) 2010-11-01
ATE557017T1 (de) 2012-05-15
RU2010146384A (ru) 2012-05-27
AU2009237794A1 (en) 2009-10-22
CN102007118A (zh) 2011-04-06
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IL207503A0 (en) 2010-12-30
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ZA201006159B (en) 2011-05-25
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