ATE517622T1 - Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten - Google Patents
Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonistenInfo
- Publication number
- ATE517622T1 ATE517622T1 AT04796120T AT04796120T ATE517622T1 AT E517622 T1 ATE517622 T1 AT E517622T1 AT 04796120 T AT04796120 T AT 04796120T AT 04796120 T AT04796120 T AT 04796120T AT E517622 T1 ATE517622 T1 AT E517622T1
- Authority
- AT
- Austria
- Prior art keywords
- salt
- tetrahydropyranylcyclopentyltetrahydropyridopyr
- diderivate
- ccr
- antagonist
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51473503P | 2003-10-27 | 2003-10-27 | |
| PCT/US2004/035069 WO2005044264A1 (en) | 2003-10-27 | 2004-10-25 | Ccr-2 antagonist salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517622T1 true ATE517622T1 (de) | 2011-08-15 |
Family
ID=34572774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04796120T ATE517622T1 (de) | 2003-10-27 | 2004-10-25 | Salz eines tetrahydropyranylcyclopentyltetrahydropyridopyr diderivats als ccr-2 antagonisten |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7473696B2 (de) |
| EP (1) | EP1682135B1 (de) |
| JP (1) | JP4542550B2 (de) |
| KR (1) | KR20060101476A (de) |
| CN (1) | CN1870998B (de) |
| AT (1) | ATE517622T1 (de) |
| AU (1) | AU2004287416C1 (de) |
| BR (1) | BRPI0415836A (de) |
| CA (1) | CA2543201C (de) |
| CO (1) | CO5690606A2 (de) |
| EC (1) | ECSP066524A (de) |
| IL (1) | IL175009A0 (de) |
| IS (1) | IS8400A (de) |
| MA (1) | MA28104A1 (de) |
| MX (1) | MXPA06004647A (de) |
| NO (1) | NO20062377L (de) |
| NZ (1) | NZ546447A (de) |
| RU (1) | RU2317295C1 (de) |
| UA (1) | UA81365C2 (de) |
| WO (1) | WO2005044264A1 (de) |
| ZA (1) | ZA200602752B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| EA010027B1 (ru) | 2002-11-27 | 2008-06-30 | Инсайт Корпорейшн | Производные 3-аминопирролидина в качестве модуляторов рецепторов хемокинов |
| AU2004222341A1 (en) * | 2003-03-18 | 2004-09-30 | Merck Sharp & Dohme Corp. | Tetrahydropyranyl cyclopentyl heterocylic amide modulators of chemokine receptor activity |
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| UA82917C2 (en) | 2003-12-18 | 2008-05-26 | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptor | |
| JP2007537264A (ja) | 2004-05-11 | 2007-12-20 | インサイト コーポレイション | ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド |
| GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| TWI366458B (en) | 2004-06-28 | 2012-06-21 | Incyte Corp | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| TW200608966A (en) | 2004-06-28 | 2006-03-16 | Incyte Corp | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors |
| CN101534824A (zh) | 2006-11-17 | 2009-09-16 | 艾博特公司 | 作为化学活素受体拮抗剂的氨基吡咯烷 |
| US20090076065A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched mk-0812 |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| EP2685978A2 (de) * | 2011-03-17 | 2014-01-22 | Merck Sharp & Dohme Corp. | Cyclohexan-substituierte amino-cyclopentan-derivate als nützliche ccr2-antagonisten |
| WO2013149376A1 (en) | 2012-04-02 | 2013-10-10 | Abbott Laboratories | Chemokine receptor antagonists |
| JP2014193854A (ja) * | 2013-02-28 | 2014-10-09 | Santen Pharmaceut Co Ltd | テトラヒドロピラニルアミノシクロペンチルカルボニルテトラヒドロピリドピリジン誘導体を有効成分として含有する後眼部疾患の予防または治療剤 |
| SI3297438T1 (sl) | 2015-05-21 | 2022-03-31 | Chemocentryx, Inc. | CCR2 modulatorji |
| KR20200110300A (ko) | 2017-09-25 | 2020-09-23 | 케모센트릭스, 인크. | 케모카인 수용체 2(ccr2) 길항제 및 pd-1/pd-l1 억제제를 사용하는 병용 요법 |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| WO2019136368A2 (en) | 2018-01-08 | 2019-07-11 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN112341350A (zh) * | 2020-10-19 | 2021-02-09 | 江苏威奇达药业有限公司 | 酶法拆分γ-内酰胺后副产物的处理方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9417249D0 (en) * | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
| JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| FR2787790A1 (fr) * | 1998-12-23 | 2000-06-30 | Sanofi Sa | Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates |
| US6500844B1 (en) * | 1999-06-11 | 2002-12-31 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| ATE337782T1 (de) | 2000-08-17 | 2006-09-15 | Merck & Co Inc | Cyclopentylmodulatoren der chemokin-rezeptor- aktivität |
| OA12532A (en) * | 2000-11-28 | 2006-06-02 | Pfizer Prod Inc | Salts of a isothiazole-4-carboxamide and their useas anti-hyperproliferation agents. |
| IL161326A0 (en) * | 2001-11-29 | 2004-09-27 | Pfizer Prod Inc | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2 (11),3,5,7,9-pentaene and pharmaceutical compositions thereof |
| JP4202926B2 (ja) * | 2001-12-12 | 2008-12-24 | ファイザー・プロダクツ・インク | Ｅ−２−メトキシ−ｎ−（３−（４−（３−メチル−ピリジン−３−イロキシ）−フェニルアミノ）−キナゾリン−６−イル）−アリル）−アセトアミドの塩形態、その製造および癌に対するその使用 |
| US7166614B2 (en) * | 2002-04-29 | 2007-01-23 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
| ES2306867T3 (es) * | 2002-04-29 | 2008-11-16 | MERCK & CO., INC. | Moduladores de la actividad receptora de quimiocinas de tetrahidro-piranil-ciclopentil-tetrahidropiridopiridina. |
| JO2479B1 (en) * | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
-
2004
- 2004-10-25 AT AT04796120T patent/ATE517622T1/de not_active IP Right Cessation
- 2004-10-25 CA CA2543201A patent/CA2543201C/en not_active Expired - Fee Related
- 2004-10-25 WO PCT/US2004/035069 patent/WO2005044264A1/en active Application Filing
- 2004-10-25 KR KR1020067008066A patent/KR20060101476A/ko not_active Application Discontinuation
- 2004-10-25 RU RU2006118352/04A patent/RU2317295C1/ru not_active IP Right Cessation
- 2004-10-25 MX MXPA06004647A patent/MXPA06004647A/es active IP Right Grant
- 2004-10-25 UA UAA200605772A patent/UA81365C2/uk unknown
- 2004-10-25 US US10/577,584 patent/US7473696B2/en not_active Expired - Fee Related
- 2004-10-25 EP EP04796120A patent/EP1682135B1/de active Active
- 2004-10-25 BR BRPI0415836-9A patent/BRPI0415836A/pt not_active IP Right Cessation
- 2004-10-25 CN CN2004800315947A patent/CN1870998B/zh not_active Expired - Fee Related
- 2004-10-25 JP JP2006538125A patent/JP4542550B2/ja not_active Expired - Fee Related
- 2004-10-25 AU AU2004287416A patent/AU2004287416C1/en not_active Ceased
- 2004-10-25 NZ NZ546447A patent/NZ546447A/en unknown
-
2006
- 2006-04-04 ZA ZA200602752A patent/ZA200602752B/xx unknown
- 2006-04-06 IS IS8400A patent/IS8400A/is unknown
- 2006-04-20 IL IL175009A patent/IL175009A0/en unknown
- 2006-04-24 MA MA28957A patent/MA28104A1/fr unknown
- 2006-04-25 CO CO06039063A patent/CO5690606A2/es unknown
- 2006-04-26 EC EC2006006524A patent/ECSP066524A/es unknown
- 2006-05-24 NO NO20062377A patent/NO20062377L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004287416A1 (en) | 2005-05-19 |
| CA2543201C (en) | 2010-12-21 |
| NO20062377L (no) | 2006-05-24 |
| UA81365C2 (en) | 2007-12-25 |
| RU2317295C1 (ru) | 2008-02-20 |
| AU2004287416C1 (en) | 2010-09-09 |
| ECSP066524A (es) | 2006-10-10 |
| EP1682135A4 (de) | 2009-11-25 |
| ZA200602752B (en) | 2007-08-29 |
| BRPI0415836A (pt) | 2007-01-02 |
| JP4542550B2 (ja) | 2010-09-15 |
| IS8400A (is) | 2006-04-06 |
| CN1870998A (zh) | 2006-11-29 |
| MXPA06004647A (es) | 2006-06-27 |
| CA2543201A1 (en) | 2005-05-19 |
| IL175009A0 (en) | 2006-08-20 |
| CN1870998B (zh) | 2010-10-20 |
| WO2005044264A1 (en) | 2005-05-19 |
| MA28104A1 (fr) | 2006-08-01 |
| CO5690606A2 (es) | 2006-10-31 |
| JP2007509940A (ja) | 2007-04-19 |
| AU2004287416B2 (en) | 2009-11-19 |
| EP1682135B1 (de) | 2011-07-27 |
| US20070135474A1 (en) | 2007-06-14 |
| US7473696B2 (en) | 2009-01-06 |
| NZ546447A (en) | 2009-02-28 |
| EP1682135A1 (de) | 2006-07-26 |
| KR20060101476A (ko) | 2006-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |