CN1870998A - Ccr-2拮抗剂盐 - Google Patents
Ccr-2拮抗剂盐 Download PDFInfo
- Publication number
- CN1870998A CN1870998A CNA2004800315947A CN200480031594A CN1870998A CN 1870998 A CN1870998 A CN 1870998A CN A2004800315947 A CNA2004800315947 A CN A2004800315947A CN 200480031594 A CN200480031594 A CN 200480031594A CN 1870998 A CN1870998 A CN 1870998A
- Authority
- CN
- China
- Prior art keywords
- trifluoromethyl
- benzodiazine
- isopropyl
- tetrahydrochysene
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Description
MSCIDIEAIPAcIPAi-PrILHMDSTHFDMFP.G.BOCNMOTFPA | 甲磺酰氯二异丙基乙胺乙酸异丙酯异丙醇2-碘丙烷六甲基二硅叠氮化锂四氢呋喃二甲基甲酰胺保护基叔丁氧基碳基N-甲基吗啉氧化物三氟丙酸 |
Claims (5)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51473503P | 2003-10-27 | 2003-10-27 | |
US60/514,735 | 2003-10-27 | ||
PCT/US2004/035069 WO2005044264A1 (en) | 2003-10-27 | 2004-10-25 | Ccr-2 antagonist salt |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1870998A true CN1870998A (zh) | 2006-11-29 |
CN1870998B CN1870998B (zh) | 2010-10-20 |
Family
ID=34572774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800315947A Expired - Fee Related CN1870998B (zh) | 2003-10-27 | 2004-10-25 | Ccr-2拮抗剂盐 |
Country Status (21)
Country | Link |
---|---|
US (1) | US7473696B2 (zh) |
EP (1) | EP1682135B1 (zh) |
JP (1) | JP4542550B2 (zh) |
KR (1) | KR20060101476A (zh) |
CN (1) | CN1870998B (zh) |
AT (1) | ATE517622T1 (zh) |
AU (1) | AU2004287416C1 (zh) |
BR (1) | BRPI0415836A (zh) |
CA (1) | CA2543201C (zh) |
CO (1) | CO5690606A2 (zh) |
EC (1) | ECSP066524A (zh) |
IL (1) | IL175009A0 (zh) |
IS (1) | IS8400A (zh) |
MA (1) | MA28104A1 (zh) |
MX (1) | MXPA06004647A (zh) |
NO (1) | NO20062377L (zh) |
NZ (1) | NZ546447A (zh) |
RU (1) | RU2317295C1 (zh) |
UA (1) | UA81365C2 (zh) |
WO (1) | WO2005044264A1 (zh) |
ZA (1) | ZA200602752B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104981243A (zh) * | 2013-02-28 | 2015-10-14 | 参天制药株式会社 | 含有四氢吡喃基氨基环戊基羰基四氢吡啶并吡啶衍生物作为有效成分的眼后段疾病的预防或治疗剂 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
JP4828829B2 (ja) | 2002-11-27 | 2011-11-30 | インサイト・コーポレイション | ケモカイン受容体のモジュレーターとしての3−アミノピロリジン誘導体 |
US7393844B2 (en) * | 2003-03-18 | 2008-07-01 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl heterocyclic amide modulators of chemokine receptor activity |
AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
US7576089B2 (en) | 2003-12-18 | 2009-08-18 | Incyte Corporation | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors |
US7307086B2 (en) | 2004-05-11 | 2007-12-11 | Incyte Corporation | 3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors |
GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
EA011487B1 (ru) | 2004-06-28 | 2009-04-28 | Инсайт Корпорейшн | 3-аминоциклопентанкарбоксамиды в качестве модуляторов хемокиновых рецепторов |
GEP20094844B (en) | 2004-06-28 | 2009-11-25 | Incyte Corp | 3-aminocyclopentane carboxamides as modulators of chemokine receptors |
MX2009005252A (es) | 2006-11-17 | 2009-05-28 | Abbott Lab | Aminopirrolidinas como antagonistas del receptor de quimiocina. |
US20090076065A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched mk-0812 |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
EP2685978A2 (en) * | 2011-03-17 | 2014-01-22 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
WO2013149376A1 (en) | 2012-04-02 | 2013-10-10 | Abbott Laboratories | Chemokine receptor antagonists |
CN108135168B (zh) | 2015-05-21 | 2021-07-20 | 凯莫森特里克斯股份有限公司 | Ccr2调节剂 |
US11304952B2 (en) | 2017-09-25 | 2022-04-19 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor |
WO2019136368A2 (en) | 2018-01-08 | 2019-07-11 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
CN112341350A (zh) * | 2020-10-19 | 2021-02-09 | 江苏威奇达药业有限公司 | 酶法拆分γ-内酰胺后副产物的处理方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9417249D0 (en) * | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
FR2787790A1 (fr) * | 1998-12-23 | 2000-06-30 | Sanofi Sa | Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates |
WO2000076512A1 (en) * | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
WO2002013824A1 (en) * | 2000-08-17 | 2002-02-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
AU1420402A (en) * | 2000-11-28 | 2002-06-11 | Pfizer Prod Inc | Salts of a isothiazole-4-carboxamide and their use as anti-hyperproliferation agents |
BR0214559A (pt) * | 2001-11-29 | 2007-03-13 | Pfizer Prod Inc | sais de ácido succìnico do 5,8,14-triazatetraciclo [10.3.1.0<2,11>.0<4,9>]-hexadeca-2(11),3,5,7,9-penteno e suas composições farmacêuticas |
NZ532436A (en) * | 2001-12-12 | 2006-01-27 | Pfizer Prod Inc | Salt forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide and method of production |
WO2003092586A2 (en) * | 2002-04-29 | 2003-11-13 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
US7166614B2 (en) * | 2002-04-29 | 2007-01-23 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydroisoquinoline modulators of chemokine receptor activity |
JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
-
2004
- 2004-10-25 NZ NZ546447A patent/NZ546447A/en unknown
- 2004-10-25 BR BRPI0415836-9A patent/BRPI0415836A/pt not_active IP Right Cessation
- 2004-10-25 CA CA2543201A patent/CA2543201C/en not_active Expired - Fee Related
- 2004-10-25 MX MXPA06004647A patent/MXPA06004647A/es active IP Right Grant
- 2004-10-25 AT AT04796120T patent/ATE517622T1/de not_active IP Right Cessation
- 2004-10-25 KR KR1020067008066A patent/KR20060101476A/ko not_active Application Discontinuation
- 2004-10-25 EP EP04796120A patent/EP1682135B1/en active Active
- 2004-10-25 US US10/577,584 patent/US7473696B2/en not_active Expired - Fee Related
- 2004-10-25 AU AU2004287416A patent/AU2004287416C1/en not_active Ceased
- 2004-10-25 CN CN2004800315947A patent/CN1870998B/zh not_active Expired - Fee Related
- 2004-10-25 RU RU2006118352/04A patent/RU2317295C1/ru not_active IP Right Cessation
- 2004-10-25 JP JP2006538125A patent/JP4542550B2/ja not_active Expired - Fee Related
- 2004-10-25 UA UAA200605772A patent/UA81365C2/uk unknown
- 2004-10-25 WO PCT/US2004/035069 patent/WO2005044264A1/en active Application Filing
-
2006
- 2006-04-04 ZA ZA200602752A patent/ZA200602752B/xx unknown
- 2006-04-06 IS IS8400A patent/IS8400A/is unknown
- 2006-04-20 IL IL175009A patent/IL175009A0/en unknown
- 2006-04-24 MA MA28957A patent/MA28104A1/fr unknown
- 2006-04-25 CO CO06039063A patent/CO5690606A2/es unknown
- 2006-04-26 EC EC2006006524A patent/ECSP066524A/es unknown
- 2006-05-24 NO NO20062377A patent/NO20062377L/no not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104981243A (zh) * | 2013-02-28 | 2015-10-14 | 参天制药株式会社 | 含有四氢吡喃基氨基环戊基羰基四氢吡啶并吡啶衍生物作为有效成分的眼后段疾病的预防或治疗剂 |
Also Published As
Publication number | Publication date |
---|---|
MXPA06004647A (es) | 2006-06-27 |
CN1870998B (zh) | 2010-10-20 |
UA81365C2 (en) | 2007-12-25 |
ATE517622T1 (de) | 2011-08-15 |
KR20060101476A (ko) | 2006-09-25 |
WO2005044264A1 (en) | 2005-05-19 |
CA2543201C (en) | 2010-12-21 |
US7473696B2 (en) | 2009-01-06 |
EP1682135B1 (en) | 2011-07-27 |
RU2317295C1 (ru) | 2008-02-20 |
AU2004287416C1 (en) | 2010-09-09 |
NZ546447A (en) | 2009-02-28 |
JP2007509940A (ja) | 2007-04-19 |
US20070135474A1 (en) | 2007-06-14 |
AU2004287416A1 (en) | 2005-05-19 |
MA28104A1 (fr) | 2006-08-01 |
IS8400A (is) | 2006-04-06 |
IL175009A0 (en) | 2006-08-20 |
EP1682135A1 (en) | 2006-07-26 |
NO20062377L (no) | 2006-05-24 |
AU2004287416B2 (en) | 2009-11-19 |
JP4542550B2 (ja) | 2010-09-15 |
BRPI0415836A (pt) | 2007-01-02 |
CO5690606A2 (es) | 2006-10-31 |
ECSP066524A (es) | 2006-10-10 |
ZA200602752B (en) | 2007-08-29 |
CA2543201A1 (en) | 2005-05-19 |
EP1682135A4 (en) | 2009-11-25 |
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Ref country code: HK Ref legal event code: DE Ref document number: 1099208 Country of ref document: HK |
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Owner name: SCHERING CORP (US) Free format text: FORMER OWNER: MSD CORP. Effective date: 20121025 |
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Owner name: MSD CORP. Free format text: FORMER NAME: SCHERING CORP (US) |
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CP01 | Change in the name or title of a patent holder |
Address after: New jersey, USA Patentee after: MERCK SHARP & DOHME Corp. Address before: New jersey, USA Patentee before: SCHERING Corp. |
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