UA81365C2 - Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition - Google Patents
Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition Download PDFInfo
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- UA81365C2 UA81365C2 UAA200605772A UAA200605772A UA81365C2 UA 81365 C2 UA81365 C2 UA 81365C2 UA A200605772 A UAA200605772 A UA A200605772A UA A200605772 A UAA200605772 A UA A200605772A UA 81365 C2 UA81365 C2 UA 81365C2
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- Ukraine
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- solution
- added
- naphthyridine
- trifluoromethyl
- pyran
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- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000010413 mother solution Substances 0.000 description 1
- PVWOIHVRPOBWPI-UHFFFAOYSA-N n-propyl iodide Chemical compound CCCI PVWOIHVRPOBWPI-UHFFFAOYSA-N 0.000 description 1
- AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- WFRLANWAASSSFV-FPLPWBNLSA-N palmitoleoyl ethanolamide Chemical compound CCCCCC\C=C/CCCCCCCC(=O)NCCO WFRLANWAASSSFV-FPLPWBNLSA-N 0.000 description 1
- XMGMFRIEKMMMSU-UHFFFAOYSA-N phenylmethylbenzene Chemical group C=1C=CC=CC=1[C]C1=CC=CC=C1 XMGMFRIEKMMMSU-UHFFFAOYSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- PNGLEYLFMHGIQO-UHFFFAOYSA-M sodium;3-(n-ethyl-3-methoxyanilino)-2-hydroxypropane-1-sulfonate;dihydrate Chemical compound O.O.[Na+].[O-]S(=O)(=O)CC(O)CN(CC)C1=CC=CC(OC)=C1 PNGLEYLFMHGIQO-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- PTSJTHMUTXBBGJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-3-carboxylate Chemical compound CC(C)(C)OC(=O)C1CNCCC1=O PTSJTHMUTXBBGJ-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51473503P | 2003-10-27 | 2003-10-27 | |
| PCT/US2004/035069 WO2005044264A1 (en) | 2003-10-27 | 2004-10-25 | Ccr-2 antagonist salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA81365C2 true UA81365C2 (en) | 2007-12-25 |
Family
ID=34572774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200605772A UA81365C2 (en) | 2003-10-27 | 2004-10-25 | Ccr-2 antagonist salt, method for modulation of chemokine receptor activity, method for treating (variants) and pharmaceutical composition |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7473696B2 (zh) |
| EP (1) | EP1682135B1 (zh) |
| JP (1) | JP4542550B2 (zh) |
| KR (1) | KR20060101476A (zh) |
| CN (1) | CN1870998B (zh) |
| AT (1) | ATE517622T1 (zh) |
| AU (1) | AU2004287416C1 (zh) |
| BR (1) | BRPI0415836A (zh) |
| CA (1) | CA2543201C (zh) |
| CO (1) | CO5690606A2 (zh) |
| EC (1) | ECSP066524A (zh) |
| IL (1) | IL175009A0 (zh) |
| IS (1) | IS8400A (zh) |
| MA (1) | MA28104A1 (zh) |
| MX (1) | MXPA06004647A (zh) |
| NO (1) | NO20062377L (zh) |
| NZ (1) | NZ546447A (zh) |
| RU (1) | RU2317295C1 (zh) |
| UA (1) | UA81365C2 (zh) |
| WO (1) | WO2005044264A1 (zh) |
| ZA (1) | ZA200602752B (zh) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2479B1 (en) | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
| US20060030582A1 (en) * | 2002-04-29 | 2006-02-09 | Demartino Julie | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| BRPI0316732B8 (pt) | 2002-11-27 | 2021-05-25 | Incyte Corp | composto derivado de 3-aminopirrolidina e sua composição farmacêutica |
| JP2007524590A (ja) * | 2003-03-18 | 2007-08-30 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性の調節剤であるテトラヒドロピラニルシクロペンチル複素環アミド |
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
| US7576089B2 (en) | 2003-12-18 | 2009-08-18 | Incyte Corporation | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors |
| JP2007537264A (ja) | 2004-05-11 | 2007-12-20 | インサイト コーポレイション | ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド |
| GB0413605D0 (en) * | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| CN102382088A (zh) | 2004-06-28 | 2012-03-21 | 因赛特公司 | 作为趋化因子受体调节剂的3-氨基环戊烷甲酰胺类 |
| KR100856156B1 (ko) | 2004-06-28 | 2008-09-03 | 인사이트 코포레이션 | 케모카인 수용체의 조절자로서의3-아미노사이클로펜탄카복스아마이드 |
| CA2669917A1 (en) | 2006-11-17 | 2008-05-22 | Dawn M. George | Aminopyrrolidines as chemokine receptor antagonists |
| US20090076065A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched mk-0812 |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| EP2685978A2 (en) * | 2011-03-17 | 2014-01-22 | Merck Sharp & Dohme Corp. | Cyclohexane substituted amino cyclopentane derivatives as useful ccr2 antagonists |
| WO2013149376A1 (en) | 2012-04-02 | 2013-10-10 | Abbott Laboratories | Chemokine receptor antagonists |
| WO2014133072A1 (ja) * | 2013-02-28 | 2014-09-04 | 参天製薬株式会社 | テトラヒドロピラニルアミノシクロペンチルカルボニルテトラヒドロピリドピリジン誘導体を有効成分として含有する後眼部疾患の予防または治療剤 |
| SI3297438T1 (sl) | 2015-05-21 | 2022-03-31 | Chemocentryx, Inc. | CCR2 modulatorji |
| CA3075638A1 (en) | 2017-09-25 | 2019-03-28 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (ccr2) antagonist and a pd-1/pd-l1 inhibitor |
| WO2019136368A2 (en) | 2018-01-08 | 2019-07-11 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
| CN112341350A (zh) * | 2020-10-19 | 2021-02-09 | 江苏威奇达药业有限公司 | 酶法拆分γ-内酰胺后副产物的处理方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9417249D0 (en) * | 1994-08-26 | 1994-10-19 | Wellcome Found | A novel salt |
| JPH09291034A (ja) * | 1996-02-27 | 1997-11-11 | Yoshitomi Pharmaceut Ind Ltd | 縮合ピリジン化合物およびその医薬としての用途 |
| FR2787790A1 (fr) * | 1998-12-23 | 2000-06-30 | Sanofi Sa | Procede de preparation du (r)-(+)-3-{1[2-(4-benzoyl-2-(3,4- difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl} -1,1-dimethyluree, de ses sels, solvats et/ou hydrates |
| WO2000076512A1 (en) * | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| JP2004506013A (ja) | 2000-08-17 | 2004-02-26 | メルク エンド カムパニー インコーポレーテッド | シクロペンチル系ケモカイン受容体活性調節剤 |
| EP1337521B1 (en) * | 2000-11-28 | 2006-09-27 | Pfizer Products Inc. | Salts of an isothiazole-4-carboxamide and their use as anti-hyperproliferation agents |
| CA2468705A1 (en) * | 2001-11-29 | 2003-06-05 | Pfizer Products Inc. | Succinic acid salts of 5,8,14-triazatetracyclo'10.3.1.0<2,11>.0<4,9>-hexadeca-2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof |
| GEP20063872B (en) * | 2001-12-12 | 2006-07-10 | Pfizer Prod Inc | Salt forms of e-2-methoxy-n-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quina-zolin-6-yl}-allyl)-acetamide and method of production |
| JO2479B1 (en) * | 2002-04-29 | 2009-01-20 | ميرك شارب اند دوم ليمتد | Rates for the activity of the chemokine receptor of tetrahydrobranyl cycloneptil tetrahydrobredo predine |
| EP1501507B1 (en) * | 2002-04-29 | 2008-05-28 | Merck & Co., Inc. | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
| DE60322877D1 (de) * | 2002-04-29 | 2008-09-25 | Merck Sharp & Dohme | Tetrahydropyranylcyclopentyltetrahydroisochino-linmodulatoren der chemokinrezeptoraktivität |
| AR045875A1 (es) * | 2003-10-27 | 2005-11-16 | Merck & Co Inc | Procedimiento para la preparacion del antagonista ccr-2 |
-
2004
- 2004-10-25 CN CN2004800315947A patent/CN1870998B/zh not_active Expired - Fee Related
- 2004-10-25 AU AU2004287416A patent/AU2004287416C1/en not_active Ceased
- 2004-10-25 KR KR1020067008066A patent/KR20060101476A/ko not_active Application Discontinuation
- 2004-10-25 WO PCT/US2004/035069 patent/WO2005044264A1/en active Application Filing
- 2004-10-25 JP JP2006538125A patent/JP4542550B2/ja not_active Expired - Fee Related
- 2004-10-25 AT AT04796120T patent/ATE517622T1/de not_active IP Right Cessation
- 2004-10-25 CA CA2543201A patent/CA2543201C/en not_active Expired - Fee Related
- 2004-10-25 MX MXPA06004647A patent/MXPA06004647A/es active IP Right Grant
- 2004-10-25 US US10/577,584 patent/US7473696B2/en not_active Expired - Fee Related
- 2004-10-25 UA UAA200605772A patent/UA81365C2/uk unknown
- 2004-10-25 BR BRPI0415836-9A patent/BRPI0415836A/pt not_active IP Right Cessation
- 2004-10-25 NZ NZ546447A patent/NZ546447A/en unknown
- 2004-10-25 EP EP04796120A patent/EP1682135B1/en active Active
- 2004-10-25 RU RU2006118352/04A patent/RU2317295C1/ru not_active IP Right Cessation
-
2006
- 2006-04-04 ZA ZA200602752A patent/ZA200602752B/xx unknown
- 2006-04-06 IS IS8400A patent/IS8400A/is unknown
- 2006-04-20 IL IL175009A patent/IL175009A0/en unknown
- 2006-04-24 MA MA28957A patent/MA28104A1/fr unknown
- 2006-04-25 CO CO06039063A patent/CO5690606A2/es unknown
- 2006-04-26 EC EC2006006524A patent/ECSP066524A/es unknown
- 2006-05-24 NO NO20062377A patent/NO20062377L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP066524A (es) | 2006-10-10 |
| KR20060101476A (ko) | 2006-09-25 |
| EP1682135A1 (en) | 2006-07-26 |
| US20070135474A1 (en) | 2007-06-14 |
| MA28104A1 (fr) | 2006-08-01 |
| AU2004287416A1 (en) | 2005-05-19 |
| AU2004287416B2 (en) | 2009-11-19 |
| CN1870998A (zh) | 2006-11-29 |
| US7473696B2 (en) | 2009-01-06 |
| JP4542550B2 (ja) | 2010-09-15 |
| AU2004287416C1 (en) | 2010-09-09 |
| NZ546447A (en) | 2009-02-28 |
| EP1682135A4 (en) | 2009-11-25 |
| RU2317295C1 (ru) | 2008-02-20 |
| CN1870998B (zh) | 2010-10-20 |
| CO5690606A2 (es) | 2006-10-31 |
| CA2543201A1 (en) | 2005-05-19 |
| IL175009A0 (en) | 2006-08-20 |
| JP2007509940A (ja) | 2007-04-19 |
| ATE517622T1 (de) | 2011-08-15 |
| CA2543201C (en) | 2010-12-21 |
| EP1682135B1 (en) | 2011-07-27 |
| NO20062377L (no) | 2006-05-24 |
| BRPI0415836A (pt) | 2007-01-02 |
| MXPA06004647A (es) | 2006-06-27 |
| IS8400A (is) | 2006-04-06 |
| ZA200602752B (en) | 2007-08-29 |
| WO2005044264A1 (en) | 2005-05-19 |
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