MY142634A - Method for synthesis of (2s,3as,7as)-perhydroindole-2-carboxylic acid and esters thereof, and use in the synthesis of perindopril - Google Patents

Method for synthesis of (2s,3as,7as)-perhydroindole-2-carboxylic acid and esters thereof, and use in the synthesis of perindopril

Info

Publication number
MY142634A
MY142634A MYPI20042237A MYPI20042237A MY142634A MY 142634 A MY142634 A MY 142634A MY PI20042237 A MYPI20042237 A MY PI20042237A MY PI20042237 A MYPI20042237 A MY PI20042237A MY 142634 A MY142634 A MY 142634A
Authority
MY
Malaysia
Prior art keywords
synthesis
perindopril
perhydroindole
esters
carboxylic acid
Prior art date
Application number
MYPI20042237A
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MY142634A publication Critical patent/MY142634A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESS FOR THE SYNTHESIS OF THE COMPOUNDS OF FORMULA (I):(I)AND ADDITION SALTS THEREOF WITH A MINERAL OR ORGANIC ACID OR BASE.APPLICATION IN THE SYNTHESIS OF PERINDOPRIL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
MYPI20042237A 2003-06-13 2004-06-10 Method for synthesis of (2s,3as,7as)-perhydroindole-2-carboxylic acid and esters thereof, and use in the synthesis of perindopril MY142634A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291420A EP1354876B1 (en) 2003-06-13 2003-06-13 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril

Publications (1)

Publication Number Publication Date
MY142634A true MY142634A (en) 2010-12-15

Family

ID=28459642

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20042237A MY142634A (en) 2003-06-13 2004-06-10 Method for synthesis of (2s,3as,7as)-perhydroindole-2-carboxylic acid and esters thereof, and use in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1354876B1 (en)
AR (1) AR044670A1 (en)
AT (1) ATE294161T1 (en)
DE (1) DE60300558T2 (en)
DK (1) DK1354876T3 (en)
ES (1) ES2240921T3 (en)
MY (1) MY142634A (en)
PT (1) PT1354876E (en)
SI (1) SI1354876T1 (en)
WO (1) WO2005003091A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100391945C (en) * 2005-05-31 2008-06-04 浙江大学 S-(-)-indolyl-2-carboxylic acid synthesizing method
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
US8558023B2 (en) 2010-04-20 2013-10-15 Chiral Quest, Inc. Enantioselective process for cycloalkenyl β-substituted alanines
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78413B (en) * 1981-12-29 1984-09-27 Hoechst Ag
FR2620703B1 (en) * 1987-09-17 1991-10-04 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES

Also Published As

Publication number Publication date
DE60300558T2 (en) 2006-02-23
AR044670A1 (en) 2005-09-21
ES2240921T3 (en) 2005-10-16
PT1354876E (en) 2005-06-30
DE60300558D1 (en) 2005-06-02
EP1354876A1 (en) 2003-10-22
DK1354876T3 (en) 2005-08-15
ATE294161T1 (en) 2005-05-15
EP1354876B1 (en) 2005-04-27
WO2005003091A1 (en) 2005-01-13
SI1354876T1 (en) 2005-08-31

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