DK1354876T3 - Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and its esters and their use in the synthesis of perindopril - Google Patents

Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and its esters and their use in the synthesis of perindopril

Info

Publication number
DK1354876T3
DK1354876T3 DK03291420T DK03291420T DK1354876T3 DK 1354876 T3 DK1354876 T3 DK 1354876T3 DK 03291420 T DK03291420 T DK 03291420T DK 03291420 T DK03291420 T DK 03291420T DK 1354876 T3 DK1354876 T3 DK 1354876T3
Authority
DK
Denmark
Prior art keywords
synthesis
perhydroindole
perindopril
esters
carboxylic acid
Prior art date
Application number
DK03291420T
Other languages
Danish (da)
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1354876T3 publication Critical patent/DK1354876T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03291420T 2003-06-13 2003-06-13 Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and its esters and their use in the synthesis of perindopril DK1354876T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03291420A EP1354876B1 (en) 2003-06-13 2003-06-13 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril

Publications (1)

Publication Number Publication Date
DK1354876T3 true DK1354876T3 (en) 2005-08-15

Family

ID=28459642

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03291420T DK1354876T3 (en) 2003-06-13 2003-06-13 Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and its esters and their use in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1354876B1 (en)
AR (1) AR044670A1 (en)
AT (1) ATE294161T1 (en)
DE (1) DE60300558T2 (en)
DK (1) DK1354876T3 (en)
ES (1) ES2240921T3 (en)
MY (1) MY142634A (en)
PT (1) PT1354876E (en)
SI (1) SI1354876T1 (en)
WO (1) WO2005003091A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100391945C (en) * 2005-05-31 2008-06-04 浙江大学 S-(-)-indolyl-2-carboxylic acid synthesizing method
EP1792896A1 (en) * 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
WO2011133651A1 (en) 2010-04-20 2011-10-27 Chiral Quest , Inc. An enantioselective process for cycloalkenyl b-substituted alanines
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
FR2620703B1 (en) * 1987-09-17 1991-10-04 Adir PROCESS FOR THE INDUSTRIAL SYNTHESIS OF PERHYDROINDOLE CARBOXYLIC ACID - 2 (2S, 3AS, 7AS). APPLICATION TO THE SYNTHESIS OF CARBOXYALKYL DIPEPTIDES

Also Published As

Publication number Publication date
ES2240921T3 (en) 2005-10-16
EP1354876A1 (en) 2003-10-22
EP1354876B1 (en) 2005-04-27
SI1354876T1 (en) 2005-08-31
MY142634A (en) 2010-12-15
ATE294161T1 (en) 2005-05-15
PT1354876E (en) 2005-06-30
WO2005003091A1 (en) 2005-01-13
AR044670A1 (en) 2005-09-21
DE60300558D1 (en) 2005-06-02
DE60300558T2 (en) 2006-02-23

Similar Documents

Publication Publication Date Title
FR2892117B1 (en) FAST GAS GENERATING PYROTECHNIC COMPOSITION AND PROCESS FOR OBTAINING THE SAME
EG24152A (en) Novel method for the synthesis of s-indoline-2-carboxylic acid and application thereof in synthesis of perindopril
ATE318838T1 (en) METHOD FOR SYNTHESIS OF (2S,3AS,7AS)-1-(S)-ALANYL-OCTAHYDRO-1H-2-CARBONIC ACID DERIVATIVES AND USE IN THE SYNTHESIS OF PERINDOPRIL
NO20043472L (en) Process for the preparation of high purity perindopril and intermediates useful in the synthesis
DK1354876T3 (en) Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and its esters and their use in the synthesis of perindopril
HK1086280A1 (en) Novel method for synthesising derivtives (2S, 3AS,7AS)-1-Ä(S)-alanylÜ-octahydro,-1hindole-2-carboxy lic acid and the use thereof for perindopril synthesis
HK1086262A1 (en) Novel method for synthesising (2s, 3as,7as)-perhydroindole-2-carboxylic acid and the esters thereof and the use thereof for perindopril synthesis
DK1420028T3 (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
DK1367061T3 (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
DK1323729T3 (en) Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and esters thereof, and their use in the synthesis of perindopril
DK1319668T3 (en) Process for the Synthesis of (2S, 3aS, 7aS) -1 - ((S) -alanyl) -octahydro-1H-indole-2-carboxylic acid derivatives and their use in the synthesis of perindopril
DK1371659T3 (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
DK1354874T3 (en) Process for the synthesis of (2S, 3aS, 7aS) -perhydroindole-2-carboxylic acid and esters thereof and their use in the synthesis of perindopril
PL379629A1 (en) Novel method for the synthesis of perindopril and the pharmaceutically-acceptable salts thereof
DK1380591T3 (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
DK1420029T3 (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
SI1354875T1 (en) Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril
DK1367063T3 (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
DK1400531T3 (en) Process for the preparation of N - [(S) -1-ethoxycarbonyl-butyl] - (S) -alanine and its use in the synthesis of perindopril
HK1095840A1 (en) Method for the synthesis of derivatives of (2s,3as,7as)-1[(s)-alanyl]- octahydro-1h-indole-2-carboxylic acid and use thereof for the synthesis of perindopril