MY135358A - New process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril - Google Patents

New process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril

Info

Publication number
MY135358A
MY135358A MYPI20040881A MYPI20040881A MY135358A MY 135358 A MY135358 A MY 135358A MY PI20040881 A MYPI20040881 A MY PI20040881A MY PI20040881 A MYPI20040881 A MY PI20040881A MY 135358 A MY135358 A MY 135358A
Authority
MY
Malaysia
Prior art keywords
synthesis
perindopril
application
alanyl
octahydro
Prior art date
Application number
MYPI20040881A
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MY135358A publication Critical patent/MY135358A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCESS FOR THE SYNTHESIS OF COMPOUNDS OF FORMULA (I): WHEREIN R₁ REPRESENTS A HYDORGEN ATOM OR AN ALKYL OR BENZYL GROUP AND R₂ REPRESENTS A PROTECTING GROUP FOR THE AMINE FUNCTION. APPLICATION IN THE SYNTHESIS OF PERINDOPRIL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF.
MYPI20040881A 2003-03-12 2004-03-12 New process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril MY135358A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290606A EP1319668B1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Publications (1)

Publication Number Publication Date
MY135358A true MY135358A (en) 2008-03-31

Family

ID=8185878

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20040881A MY135358A (en) 2003-03-12 2004-03-12 New process for the synthesis of (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxylic acid compounds and application in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1319668B1 (en)
AR (1) AR043568A1 (en)
AT (1) ATE280775T1 (en)
DE (1) DE60300106T2 (en)
DK (1) DK1319668T3 (en)
ES (1) ES2231759T3 (en)
MY (1) MY135358A (en)
PT (1) PT1319668E (en)
SI (2) SI1319668T1 (en)
WO (1) WO2004082357A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1367062T3 (en) * 2003-07-31 2007-01-02 Servier Lab New method for synthesis of perindopril and pharmaceutically acceptable salts thereof
ES2272922T3 (en) * 2003-08-29 2007-05-01 Les Laboratoires Servier NEW SYNTHESIS PROCEDURE OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS.
DK1371659T3 (en) 2003-08-29 2005-11-21 Servier Lab Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
SI1380591T1 (en) * 2003-08-29 2006-02-28 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2827860B1 (en) * 2001-07-24 2004-12-10 Servier Lab NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL

Also Published As

Publication number Publication date
PT1319668E (en) 2005-02-28
WO2004082357A3 (en) 2004-10-28
EP1319668A1 (en) 2003-06-18
DE60300106D1 (en) 2004-12-02
DE60300106T2 (en) 2005-10-13
AR043568A1 (en) 2005-08-03
SI1323729T1 (en) 2005-02-28
ATE280775T1 (en) 2004-11-15
EP1319668B1 (en) 2004-10-27
ES2231759T3 (en) 2005-05-16
WO2004082357A2 (en) 2004-09-30
DK1319668T3 (en) 2005-02-14
SI1319668T1 (en) 2005-02-28

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