SI1319668T1 - Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril - Google Patents

Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Info

Publication number
SI1319668T1
SI1319668T1 SI200330008T SI200330008T SI1319668T1 SI 1319668 T1 SI1319668 T1 SI 1319668T1 SI 200330008 T SI200330008 T SI 200330008T SI 200330008 T SI200330008 T SI 200330008T SI 1319668 T1 SI1319668 T1 SI 1319668T1
Authority
SI
Slovenia
Prior art keywords
synthesis
perindopril
alanyl
octahydro
indole
Prior art date
Application number
SI200330008T
Other languages
Slovenian (sl)
Inventor
Thierry Dubuffet
Jean-Pierre Lecouve
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1319668T1 publication Critical patent/SI1319668T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200330008T 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril SI1319668T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03290606A EP1319668B1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Publications (1)

Publication Number Publication Date
SI1319668T1 true SI1319668T1 (en) 2005-02-28

Family

ID=8185878

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200330007T SI1323729T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril
SI200330008T SI1319668T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-1-((S)-alanyl)-octahydro-1H-indole-2-carboxylic acid derivatives and use in the synthesis of perindopril

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI200330007T SI1323729T1 (en) 2003-03-12 2003-03-12 Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof derivatives; and use in the synthesis of perindopril

Country Status (10)

Country Link
EP (1) EP1319668B1 (en)
AR (1) AR043568A1 (en)
AT (1) ATE280775T1 (en)
DE (1) DE60300106T2 (en)
DK (1) DK1319668T3 (en)
ES (1) ES2231759T3 (en)
MY (1) MY135358A (en)
PT (1) PT1319668E (en)
SI (2) SI1323729T1 (en)
WO (1) WO2004082357A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1367062T1 (en) * 2003-07-31 2006-12-31 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts
SI1371659T1 (en) * 2003-08-29 2006-02-28 Servier Lab Method for synthesis of perindopril and its pharmaceutically acceptable salts (2003/26)
ATE338766T1 (en) * 2003-08-29 2006-09-15 Servier Lab METHOD FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
ES2252633T3 (en) * 2003-08-29 2006-05-16 Les Laboratoires Servier NEW SYNTHESIS PROCEDURE OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE BASES.
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ202903A (en) * 1981-12-29 1988-01-08 Hoechst Ag 1-- pe pyrrol-2-yl-carboxylic acid derivatives and pharmaceutical compositions
FR2807431B1 (en) * 2000-04-06 2002-07-19 Adir NOVEL PROCESS FOR THE SYNTHESIS OF PERINDOPRIL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
FR2827860B1 (en) * 2001-07-24 2004-12-10 Servier Lab NOVEL PROCESS FOR SYNTHESIS OF ACID DERIVATIVES (2S, 3AS, 7AS) -1 - [(S) -ALANYL] -OCTAHYDRO-1H-INDOLE-2-CARBOXYLINE AND APPLICATION TO THE SYNTHESIS OF PERINDOPRIL

Also Published As

Publication number Publication date
ES2231759T3 (en) 2005-05-16
DE60300106D1 (en) 2004-12-02
DK1319668T3 (en) 2005-02-14
AR043568A1 (en) 2005-08-03
WO2004082357A2 (en) 2004-09-30
EP1319668A1 (en) 2003-06-18
DE60300106T2 (en) 2005-10-13
PT1319668E (en) 2005-02-28
ATE280775T1 (en) 2004-11-15
MY135358A (en) 2008-03-31
SI1323729T1 (en) 2005-02-28
WO2004082357A3 (en) 2004-10-28
EP1319668B1 (en) 2004-10-27

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