AU2002218075A1 - Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them - Google Patents

Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them

Info

Publication number
AU2002218075A1
AU2002218075A1 AU2002218075A AU1807502A AU2002218075A1 AU 2002218075 A1 AU2002218075 A1 AU 2002218075A1 AU 2002218075 A AU2002218075 A AU 2002218075A AU 1807502 A AU1807502 A AU 1807502A AU 2002218075 A1 AU2002218075 A1 AU 2002218075A1
Authority
AU
Australia
Prior art keywords
intermediates
producing
pharmaceutical compositions
compositions containing
contrast agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002218075A
Inventor
Paul Adriaens
Erwin Cresens
Guy Marchal
Yicheng Ni
Alfons Verbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0027249A external-priority patent/GB2368843A/en
Priority claimed from GB0120659A external-priority patent/GB0120659D0/en
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Publication of AU2002218075A1 publication Critical patent/AU2002218075A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/122—Macromolecular compounds dimers of complexes or complex-forming compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2002218075A 2000-11-08 2001-11-07 Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them Abandoned AU2002218075A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0027249A GB2368843A (en) 2000-11-08 2000-11-08 Non-porphyrin multipurpose contrast agents
GB0027249 2000-11-08
GB0120659A GB0120659D0 (en) 2001-08-28 2001-08-28 New generation of multipurpose contrast agents
GB0120659 2001-08-28
PCT/BE2001/000192 WO2002038546A1 (en) 2000-11-08 2001-11-07 Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them

Publications (1)

Publication Number Publication Date
AU2002218075A1 true AU2002218075A1 (en) 2002-05-21

Family

ID=26245253

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002218075A Abandoned AU2002218075A1 (en) 2000-11-08 2001-11-07 Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them

Country Status (5)

Country Link
US (1) US7081472B2 (en)
EP (1) EP1343758A1 (en)
CN (1) CN100352805C (en)
AU (1) AU2002218075A1 (en)
WO (1) WO2002038546A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1506402A2 (en) * 2002-03-28 2005-02-16 Rutgers, The State University of New Jersey Bis-transition-metal-chelate-probes
DE602004008590T2 (en) * 2003-01-31 2008-05-21 Otsuka Pharmaceutical Factory, Inc., Naruto AUXILIARY FOR USE IN CANCER THERAPY USING DIELECTRIC WARMING AND CANCER THERAPY PROCEDURES
US20070098631A2 (en) * 2004-04-28 2007-05-03 Guerbet Diagnostic compounds comprising a scaffold coupled to a signal entity for medical imaging diagnostic
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
WO2009104198A2 (en) * 2008-01-25 2009-08-27 Vlife Sciences Technologies Pvt. Ltd. Metal conjugates of indole 3- aldehyde azine and its derivatives and uses thereof
FR2942227B1 (en) 2009-02-13 2011-04-15 Guerbet Sa USE OF BUFFERS FOR RADIONUCLEID COMPLEXATION
US20110077396A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US20110077417A1 (en) * 2009-09-30 2011-03-31 General Electric Company Intermediates for Hydroxylated Contrast Enhancement Agents
US8378134B2 (en) * 2009-09-30 2013-02-19 General Electric Company Hydroxylated contrast enhancement agents
FR2968999B1 (en) 2010-12-20 2013-01-04 Guerbet Sa CHELATE NANOEMULSION FOR MRI
WO2012142702A1 (en) * 2011-04-20 2012-10-26 Rf Therapeutics Inc. Targeted contrast agents and uses thereof
FR2980364B1 (en) 2011-09-26 2018-08-31 Guerbet NANOEMULSIONS AND THEIR USE AS CONTRAST AGENTS
FR3001154B1 (en) 2013-01-23 2015-06-26 Guerbet Sa MAGNETO-EMULSION VECTORIZED
JP6796594B2 (en) 2014-12-11 2020-12-09 アールエフ セラピューティクス インコーポレイテッド Contrast agents and their uses
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof
WO2023049476A1 (en) * 2021-09-27 2023-03-30 The University Of North Carolina At Chapel Hill Catalytic methods for carbonylation of esters

Family Cites Families (31)

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Publication number Priority date Publication date Assignee Title
CH474533A (en) 1966-12-14 1969-06-30 Geigy Ag J R Process for the preparation of bis-carboxylic acid anhydrides
US3954799A (en) 1971-01-21 1976-05-04 Polaroid Corporation Protonated indole phthalides and naphthalides
US4430269A (en) 1982-04-01 1984-02-07 Eli Lilly And Company 12'-Iodo derivatives of dimeric indole-dihydroindole alkaloids, and process for preparing them
US4861869A (en) 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US5202451A (en) 1988-02-17 1993-04-13 Neorx Corporation Anchimeric radiometal chelating compounds
US5075099A (en) 1988-05-31 1991-12-24 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5196515A (en) 1989-03-17 1993-03-23 The Johns Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
US5808003A (en) 1989-05-26 1998-09-15 Perimmune Holdings, Inc. Polyaminocarboxylate chelators
US5164176A (en) 1989-06-16 1992-11-17 Neorx Corporation Radionuclide metal chelates for the radiolabeling of proteins
GB9027922D0 (en) * 1990-12-21 1991-02-13 Nycomed As Compounds
DE4124989A1 (en) 1991-07-27 1993-02-04 Basf Ag (BETA) -SUBSTITUTED CINNAMENT DERIVATIVES
US5808091A (en) 1991-10-29 1998-09-15 Bracco International B.V. Rhenium and technetium complexes containing a hypoxia localizing moiety
US5220000A (en) 1992-01-23 1993-06-15 Spyros Theodoropulos Bifunctional-bis-quinolinols, and their metal chelates
US5326856A (en) 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
JPH08503450A (en) 1992-08-06 1996-04-16 ワーナー−ランバート・コンパニー 2-Thioindole (selenoindole) and related disulfides (selenides) that inhibit protein tyrosine kinases and have antitumor properties
US5756825A (en) 1992-09-08 1998-05-26 Safavy; Ahmad Hydroxamic acid-based bifunctional chelating compounds
US5556939A (en) 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5632969A (en) 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
DE19508058A1 (en) 1995-02-21 1996-08-22 Schering Ag Process for the preparation of DTPA tetraesters of the terminal carboxylic acids and their use for the production of pharmaceutical agents
GB9523999D0 (en) 1995-11-23 1996-01-24 Lilly Co Eli Indolyl neuropeptide y receptor antagonists
JPH10512899A (en) 1995-11-15 1998-12-08 スローン−ケッタリング インスティテュート フォー キャンサー リサーチ Analogs of N-acetyl ardeemin, methods for their preparation and use
IT1283650B1 (en) 1996-08-02 1998-04-23 Bracco Spa HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM
US5811551A (en) 1996-08-13 1998-09-22 Merck & Co., Inc. Palladium catalyzed indolization
US5808064A (en) 1996-08-13 1998-09-15 Merck & Co., Inc. Palladium catalyzed indolization
US5877329A (en) 1996-08-13 1999-03-02 Merck & Co., Inc. Palladium catalyzed indolization
US5948808A (en) 1997-03-07 1999-09-07 The Texas A&M University System Indole-3-carbinol, diindolylmethane and substituted analogs as antiestrogens
EP0887348A1 (en) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
US5932743A (en) 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds
US6093382A (en) 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
EP0998946A1 (en) 1998-08-14 2000-05-10 K.U. Leuven Research & Development Non-porphyrin compound for use as a diagnosticum and/or pharmaceutical
US6056939A (en) 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals

Also Published As

Publication number Publication date
US20040053911A1 (en) 2004-03-18
WO2002038546A1 (en) 2002-05-16
US7081472B2 (en) 2006-07-25
CN1486299A (en) 2004-03-31
EP1343758A1 (en) 2003-09-17
CN100352805C (en) 2007-12-05

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