IT1283650B1 - HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM - Google Patents

HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM

Info

Publication number
IT1283650B1
IT1283650B1 IT96MI001684A ITMI961684A IT1283650B1 IT 1283650 B1 IT1283650 B1 IT 1283650B1 IT 96MI001684 A IT96MI001684 A IT 96MI001684A IT MI961684 A ITMI961684 A IT MI961684A IT 1283650 B1 IT1283650 B1 IT 1283650B1
Authority
IT
Italy
Prior art keywords
serum
high relaxation
paramagnetic chelates
chelates
paramagnetic
Prior art date
Application number
IT96MI001684A
Other languages
Italian (it)
Inventor
Marco Lolli
Luisella Calabi
Alessanfro Maiocchi
Fabrizio Rebasti
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Priority to IT96MI001684A priority Critical patent/IT1283650B1/en
Publication of ITMI961684A0 publication Critical patent/ITMI961684A0/it
Priority to PCT/EP1997/004096 priority patent/WO1998005625A1/en
Priority to JP50542598A priority patent/JP4225573B2/en
Priority to AU42029/97A priority patent/AU4202997A/en
Priority to EP97940037A priority patent/EP0915829A1/en
Priority to ZA9706891A priority patent/ZA976891B/en
Publication of ITMI961684A1 publication Critical patent/ITMI961684A1/en
Application granted granted Critical
Publication of IT1283650B1 publication Critical patent/IT1283650B1/en
Priority to US09/612,392 priority patent/US6403055B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
IT96MI001684A 1996-08-02 1996-08-02 HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM IT1283650B1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT96MI001684A IT1283650B1 (en) 1996-08-02 1996-08-02 HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM
PCT/EP1997/004096 WO1998005625A1 (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agent with improved in-serum-relaxivity
JP50542598A JP4225573B2 (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agents with improved serum relaxation
AU42029/97A AU4202997A (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agent with improved in-serum-relaxivity
EP97940037A EP0915829A1 (en) 1996-08-02 1997-07-28 Diagnostic imaging contrast agent with improved in-serum-relaxivity
ZA9706891A ZA976891B (en) 1996-08-02 1997-08-01 Diagnostic imaging contrast agent.
US09/612,392 US6403055B1 (en) 1996-08-02 2000-07-07 Diagnostic imaging contrast agent with improved in serum relaxivity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI001684A IT1283650B1 (en) 1996-08-02 1996-08-02 HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM

Publications (3)

Publication Number Publication Date
ITMI961684A0 ITMI961684A0 (en) 1996-08-02
ITMI961684A1 ITMI961684A1 (en) 1998-02-02
IT1283650B1 true IT1283650B1 (en) 1998-04-23

Family

ID=11374755

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI001684A IT1283650B1 (en) 1996-08-02 1996-08-02 HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM

Country Status (6)

Country Link
EP (1) EP0915829A1 (en)
JP (1) JP4225573B2 (en)
AU (1) AU4202997A (en)
IT (1) IT1283650B1 (en)
WO (1) WO1998005625A1 (en)
ZA (1) ZA976891B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (en) 1995-02-01 1997-11-11 Epix Medical Inc
IL134985A0 (en) 1997-10-02 2001-05-20 Epix Medical Inc A method for contrast enhanced diagnostic imaging
IT1298613B1 (en) 1998-03-10 2000-01-12 Bracco Spa HIGH RELAXATION MANGANESE COMPLEX CHELATES IN SERUM
IT1298614B1 (en) * 1998-03-10 2000-01-12 Bracco Spa HIGH RELAXATION MANGANESE COMPLEX CHELATES IN SERUM
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
AU2002218075A1 (en) 2000-11-08 2002-05-21 K.U. Leuven Research And Development Substituted bis-indole derivatives useful as contrast agents, pharmaceutical compositions containing them and intermediates for producing them
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
US7893223B2 (en) 2001-07-17 2011-02-22 Bracco Imaging S.P.A. Multidentate AZA ligands able to complex metal ions and the use thereof in diagnostics and therapy
ITMI20011518A1 (en) * 2001-07-17 2003-01-17 Bracco Imaging Spa MULTIDENTATED NITROGEN BINDERS CAPABLE OF COMPLEXING METAL IONS AND THEIR USE IN DIAGNOSTICS AND THERAPY
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
CN115611757A (en) * 2021-07-16 2023-01-17 江苏慧聚药业股份有限公司 Synthesis of mRNA delivery Agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57183471A (en) * 1981-04-30 1982-11-11 Takemoto Oil & Fat Co Ltd Synthetic fiber treating oil agent
IT1213029B (en) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa PARAMAGNETIC METAL ION CHELATES.
EP0713139B1 (en) * 1994-10-20 1998-06-03 Fuji Photo Film Co., Ltd. Novel, iron complex, process for producing the same, photographic processing composition and processing process using the same
US5672335A (en) * 1994-11-30 1997-09-30 Schering Aktiengesellschaft Use of metal complexes as liver and gallbladder X-ray diagnostic agents

Also Published As

Publication number Publication date
WO1998005625A1 (en) 1998-02-12
EP0915829A1 (en) 1999-05-19
ITMI961684A1 (en) 1998-02-02
JP2000516915A (en) 2000-12-19
AU4202997A (en) 1998-02-25
ITMI961684A0 (en) 1996-08-02
ZA976891B (en) 1998-05-11
JP4225573B2 (en) 2009-02-18

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Legal Events

Date Code Title Description
0001 Granted