BRPI0510163A - compostos de amidas tri(ciclo)-substituìdas - Google Patents
compostos de amidas tri(ciclo)-substituìdasInfo
- Publication number
- BRPI0510163A BRPI0510163A BRPI0510163-8A BRPI0510163A BRPI0510163A BR PI0510163 A BRPI0510163 A BR PI0510163A BR PI0510163 A BRPI0510163 A BR PI0510163A BR PI0510163 A BRPI0510163 A BR PI0510163A
- Authority
- BR
- Brazil
- Prior art keywords
- tri
- cyclo
- amide compounds
- substituted amide
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
COMPOSTOS DE AMIDAS TRI (CICLO)-SUBSTITUìDAS. A presente invenção refere-se a compostos da Fórmula (I) ou seus sais farmaceuticamente aceitáveis, que são úteis no tratamento profilático e terapêutico de hiperglicemia e diabetes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56417104P | 2004-04-21 | 2004-04-21 | |
US60107704P | 2004-08-12 | 2004-08-12 | |
PCT/GB2005/050053 WO2005103021A1 (en) | 2004-04-21 | 2005-04-19 | Tri(cyclo) substituted amide compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0510163A true BRPI0510163A (pt) | 2007-10-02 |
Family
ID=34965439
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0510163-8A BRPI0510163A (pt) | 2004-04-21 | 2005-04-19 | compostos de amidas tri(ciclo)-substituìdas |
Country Status (15)
Country | Link |
---|---|
US (1) | US20080242869A1 (pt) |
EP (1) | EP1740560A1 (pt) |
JP (1) | JP2007533722A (pt) |
KR (1) | KR20060134179A (pt) |
AU (1) | AU2005235798A1 (pt) |
BR (1) | BRPI0510163A (pt) |
CA (1) | CA2563192A1 (pt) |
EA (1) | EA012204B1 (pt) |
IL (1) | IL178473A0 (pt) |
MA (1) | MA28545B1 (pt) |
MX (1) | MXPA06012008A (pt) |
NO (1) | NO20065260L (pt) |
NZ (1) | NZ550567A (pt) |
WO (1) | WO2005103021A1 (pt) |
ZA (1) | ZA200608489B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ539013A (en) | 2002-10-03 | 2007-05-31 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
JP4700684B2 (ja) | 2004-04-02 | 2011-06-15 | ノバルティス アーゲー | 2型糖尿病の処置に有用なグルコキナーゼアクティベーターとしてのスルホンアミド−チアゾロピリジン誘導体 |
CA2561157A1 (en) | 2004-04-02 | 2005-10-13 | Novartis Ag | Thiazolopyridine derivatives, pharmaceutical conditions containing them and methods of treating glucokinase mediated conditions |
BRPI0514147A (pt) * | 2004-08-12 | 2008-05-27 | Prosidion Ltd | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de tratamento profilático ou terapêutico de uma condição onde a ativação de gk é desejável, de tratamento profilático ou terapêutico da hiperglicemia ou diabete e de prevenção da diabete em um ser humano que demosntra hiperglicemia pré-diabética ou toleráncia à glicose prejudicada, e, processo para a preparação do composto |
GB0418058D0 (en) * | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Fluorination process |
JP2009509988A (ja) | 2005-09-29 | 2009-03-12 | サノフィ−アベンティス | フェニル−及びピリジニル−1,2,4−オキサジアゾロン誘導体、その製造方法、及び医薬品としてのその使用 |
GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
US20080293741A1 (en) * | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
EP2046755A2 (en) | 2006-07-24 | 2009-04-15 | F. Hoffmann-Roche AG | Pyrazoles as glucokinase activators |
US7902248B2 (en) | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
TW200831081A (en) | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
WO2008111473A1 (ja) * | 2007-03-07 | 2008-09-18 | Kyorin Pharmaceutical Co., Ltd. | グルコキナーゼ活性化物質 |
PE20091313A1 (es) * | 2008-01-15 | 2009-09-03 | Lilly Co Eli | (r)-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida cristalina |
RU2010134411A (ru) | 2008-01-18 | 2012-02-27 | Астеллас Фарма Инк. (Jp) | Фенилацетамидное производное |
US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
CA2722733C (en) | 2008-04-28 | 2016-02-23 | Kyorin Pharmaceutical Co., Ltd. | Cyclopentylacrylamide derivative |
NZ589084A (en) | 2008-05-16 | 2012-06-29 | Takeda San Diego Inc | Glucokinase activators |
JP2012510979A (ja) * | 2008-12-08 | 2012-05-17 | ユーロスクリーン・ソシエテ・アノニム | 化合物、薬学的組成物および代謝障害の治療において使用するための方法 |
UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
US20130281708A1 (en) | 2010-03-18 | 2013-10-24 | Takeda California, Inc. | Process for the Production of 2-Amino-5-Fluorothiazole |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
KR100455635B1 (ko) * | 1999-03-29 | 2004-11-06 | 에프. 호프만-라 로슈 아게 | 글루코키나제 활성화제 |
US6353111B1 (en) * | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
DE60106599T2 (de) * | 2000-05-08 | 2006-02-09 | F. Hoffmann-La Roche Ag | Substituierte phenylacetamide und ihre verwendung als glukokinase aktivatoren |
JP4138478B2 (ja) * | 2000-07-20 | 2008-08-27 | エフ.ホフマン−ラ ロシュ アーゲー | アルファ−アシル及びアルファ−ヘテロ原子置換ベンゼンアセトアミドのグルコキナーゼアクチベーター |
AU2190202A (en) * | 2000-12-06 | 2002-06-18 | Hoffmann La Roche | Fused heteroaromatic glucokinase activators |
ES2276097T3 (es) * | 2002-04-26 | 2007-06-16 | F. Hoffmann-La Roche Ag | Fenilacetamidas sustituidas y su empleo0 como activadores de glucoquinasa. |
PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
-
2005
- 2005-04-19 WO PCT/GB2005/050053 patent/WO2005103021A1/en active Application Filing
- 2005-04-19 NZ NZ550567A patent/NZ550567A/en not_active IP Right Cessation
- 2005-04-19 JP JP2007508982A patent/JP2007533722A/ja not_active Withdrawn
- 2005-04-19 MX MXPA06012008A patent/MXPA06012008A/es unknown
- 2005-04-19 CA CA002563192A patent/CA2563192A1/en not_active Abandoned
- 2005-04-19 EP EP05732317A patent/EP1740560A1/en not_active Withdrawn
- 2005-04-19 US US11/578,752 patent/US20080242869A1/en not_active Abandoned
- 2005-04-19 EA EA200601747A patent/EA012204B1/ru not_active IP Right Cessation
- 2005-04-19 KR KR1020067022240A patent/KR20060134179A/ko not_active Application Discontinuation
- 2005-04-19 AU AU2005235798A patent/AU2005235798A1/en not_active Abandoned
- 2005-04-19 BR BRPI0510163-8A patent/BRPI0510163A/pt not_active IP Right Cessation
-
2006
- 2006-10-05 IL IL178473A patent/IL178473A0/en unknown
- 2006-10-11 ZA ZA2006/08489A patent/ZA200608489B/en unknown
- 2006-10-20 MA MA29401A patent/MA28545B1/fr unknown
- 2006-11-15 NO NO20065260A patent/NO20065260L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EA200601747A1 (ru) | 2007-04-27 |
EA012204B1 (ru) | 2009-08-28 |
EP1740560A1 (en) | 2007-01-10 |
JP2007533722A (ja) | 2007-11-22 |
ZA200608489B (en) | 2008-06-25 |
NO20065260L (no) | 2006-11-21 |
CA2563192A1 (en) | 2005-11-03 |
NZ550567A (en) | 2010-07-30 |
IL178473A0 (en) | 2007-02-11 |
AU2005235798A1 (en) | 2005-11-03 |
KR20060134179A (ko) | 2006-12-27 |
MXPA06012008A (es) | 2007-01-25 |
US20080242869A1 (en) | 2008-10-02 |
WO2005103021A1 (en) | 2005-11-03 |
MA28545B1 (fr) | 2007-04-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |