BR112014027584A2 - compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1 - Google Patents
compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1Info
- Publication number
- BR112014027584A2 BR112014027584A2 BR112014027584A BR112014027584A BR112014027584A2 BR 112014027584 A2 BR112014027584 A2 BR 112014027584A2 BR 112014027584 A BR112014027584 A BR 112014027584A BR 112014027584 A BR112014027584 A BR 112014027584A BR 112014027584 A2 BR112014027584 A2 BR 112014027584A2
- Authority
- BR
- Brazil
- Prior art keywords
- abl1
- compounds
- bcr
- inhibiting
- activity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4965—Non-condensed pyrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D233/32—One oxygen atom
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
resumo patente de invenção: "compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1". a presente invenção refere-se a compostos de fórmula i: em que y, y1, y4, y5, y6, r1, r2, r3 e r4 são definidos no sumário da invenção; capaz de inibir a atividade de bcr-abl1 e mutantes dos mesmos. a invenção também fornece um processo para a preparação de compostos da invenção, preparações farmacêuticas compreendendo, tais compostos e métodos de utilização, tais compostos no tratamento de cânceres.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US201261647197P | 2012-05-15 | 2012-05-15 | |
US61/647,197 | 2012-05-15 | ||
US201361787513P | 2013-03-15 | 2013-03-15 | |
US61/787,513 | 2013-03-15 | ||
PCT/IB2013/053770 WO2013171641A1 (en) | 2012-05-15 | 2013-05-09 | Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1 |
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BR112014027584A2 true BR112014027584A2 (pt) | 2017-06-27 |
BR112014027584B1 BR112014027584B1 (pt) | 2023-01-24 |
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US (2) | US9315489B2 (pt) |
EP (1) | EP2900637B1 (pt) |
JP (1) | JP6080947B2 (pt) |
KR (1) | KR102190848B1 (pt) |
CN (1) | CN104334529B (pt) |
AU (1) | AU2013261129B2 (pt) |
BR (1) | BR112014027584B1 (pt) |
CA (1) | CA2870339C (pt) |
EA (1) | EA026559B1 (pt) |
ES (1) | ES2646777T3 (pt) |
MX (1) | MX357305B (pt) |
PL (1) | PL2900637T3 (pt) |
PT (1) | PT2900637T (pt) |
WO (1) | WO2013171641A1 (pt) |
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JP6080947B2 (ja) | 2017-02-15 |
ES2646777T3 (es) | 2017-12-15 |
AU2013261129B2 (en) | 2016-05-12 |
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PT2900637T (pt) | 2017-11-15 |
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BR112014027584B1 (pt) | 2023-01-24 |
CN104334529A (zh) | 2015-02-04 |
US9315489B2 (en) | 2016-04-19 |
WO2013171641A1 (en) | 2013-11-21 |
CN104334529B (zh) | 2017-03-15 |
AU2013261129A1 (en) | 2014-10-23 |
US20160185733A1 (en) | 2016-06-30 |
KR102190848B1 (ko) | 2020-12-15 |
MX2014013375A (es) | 2015-08-14 |
EP2900637A1 (en) | 2015-08-05 |
EA201492092A1 (ru) | 2015-03-31 |
EA026559B1 (ru) | 2017-04-28 |
US9458112B2 (en) | 2016-10-04 |
CA2870339A1 (en) | 2013-11-21 |
PL2900637T3 (pl) | 2018-01-31 |
US20150141427A1 (en) | 2015-05-21 |
CA2870339C (en) | 2020-06-02 |
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