BR112014027584A2 - compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1 - Google Patents

compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1

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Publication number
BR112014027584A2
BR112014027584A2 BR112014027584A BR112014027584A BR112014027584A2 BR 112014027584 A2 BR112014027584 A2 BR 112014027584A2 BR 112014027584 A BR112014027584 A BR 112014027584A BR 112014027584 A BR112014027584 A BR 112014027584A BR 112014027584 A2 BR112014027584 A2 BR 112014027584A2
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BR
Brazil
Prior art keywords
abl1
compounds
bcr
inhibiting
activity
Prior art date
Application number
BR112014027584A
Other languages
English (en)
Other versions
BR112014027584B1 (pt
Inventor
Marzinzik Andreas
Salem Bahaa
Brynley Jones Darryl
Schoepfer Joseph
Furet Pascal
Manley Paul
Martin Grotzfeld Robert
Moussaoui Saliha
Jahnke Wolfgang
Francois Andre Pelle Xavier
Original Assignee
Novartis Ag
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Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014027584A2 publication Critical patent/BR112014027584A2/pt
Publication of BR112014027584B1 publication Critical patent/BR112014027584B1/pt

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    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

resumo patente de invenção: "compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1". a presente invenção refere-se a compostos de fórmula i: em que y, y1, y4, y5, y6, r1, r2, r3 e r4 são definidos no sumário da invenção; capaz de inibir a atividade de bcr-abl1 e mutantes dos mesmos. a invenção também fornece um processo para a preparação de compostos da invenção, preparações farmacêuticas compreendendo, tais compostos e métodos de utilização, tais compostos no tratamento de cânceres.
BR112014027584-0A 2012-05-15 2013-05-09 Uso de inibidores da atividade de abl1, abl2 e bcr-abl1, e composição farmacêutica BR112014027584B1 (pt)

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US61/647,197 2012-05-15
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US61/787,513 2013-03-15
PCT/IB2013/053770 WO2013171641A1 (en) 2012-05-15 2013-05-09 Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1

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MX357305B (es) 2018-07-04
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