PL2900637T3 - Pirymidyna podstawiona tiazolem lub imidazolem, amidowe pochodne pirazyny i pirydyny i powiązane związki takie jak inhibitory abl1, abl2 i bcr-abl1 do leczenia nowotworu, specyficznych infekcji wirusowych i specyficznych zaburzeń cns - Google Patents

Pirymidyna podstawiona tiazolem lub imidazolem, amidowe pochodne pirazyny i pirydyny i powiązane związki takie jak inhibitory abl1, abl2 i bcr-abl1 do leczenia nowotworu, specyficznych infekcji wirusowych i specyficznych zaburzeń cns

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Publication number
PL2900637T3
PL2900637T3 PL13730654T PL13730654T PL2900637T3 PL 2900637 T3 PL2900637 T3 PL 2900637T3 PL 13730654 T PL13730654 T PL 13730654T PL 13730654 T PL13730654 T PL 13730654T PL 2900637 T3 PL2900637 T3 PL 2900637T3
Authority
PL
Poland
Prior art keywords
abl1
specific
abl2
bcr
thiazole
Prior art date
Application number
PL13730654T
Other languages
English (en)
Inventor
Pascal Furet
Robert Martin Grotzfeld
Darryl Brynley Jones
Paul Manley
Andreas Marzinzik
Saliha Moussaoui
Xavier Francois Andre Pelle
Bahaa Salem
Joseph Schoepfer
Wolfgang Jahnke
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL2900637T3 publication Critical patent/PL2900637T3/pl

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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PL13730654T 2012-05-15 2013-05-09 Pirymidyna podstawiona tiazolem lub imidazolem, amidowe pochodne pirazyny i pirydyny i powiązane związki takie jak inhibitory abl1, abl2 i bcr-abl1 do leczenia nowotworu, specyficznych infekcji wirusowych i specyficznych zaburzeń cns PL2900637T3 (pl)

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EP13730654.4A EP2900637B1 (en) 2012-05-15 2013-05-09 Thiazole or imidazole substituted pyrimidine, pyridine and pyrazine amide derivatives and related compounds as abl1, abl2 and bcr-abl1 inhibitors for the treatment of cancer, specific viral infections and specific cns disorders

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US20150141427A1 (en) 2015-05-21
BR112014027584A2 (pt) 2017-06-27
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AU2013261129A1 (en) 2014-10-23
JP6080947B2 (ja) 2017-02-15
KR102190848B1 (ko) 2020-12-15
EA026559B1 (ru) 2017-04-28
CA2870339A1 (en) 2013-11-21
PT2900637T (pt) 2017-11-15
US20160185733A1 (en) 2016-06-30
AU2013261129B2 (en) 2016-05-12
JP2015520157A (ja) 2015-07-16
US9315489B2 (en) 2016-04-19
EP2900637B1 (en) 2017-08-09
US9458112B2 (en) 2016-10-04
MX2014013375A (es) 2015-08-14
CN104334529B (zh) 2017-03-15
CA2870339C (en) 2020-06-02
CN104334529A (zh) 2015-02-04

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