BR112015011974A8 - derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica - Google Patents
derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica Download PDFInfo
- Publication number
- BR112015011974A8 BR112015011974A8 BR112015011974A BR112015011974A BR112015011974A8 BR 112015011974 A8 BR112015011974 A8 BR 112015011974A8 BR 112015011974 A BR112015011974 A BR 112015011974A BR 112015011974 A BR112015011974 A BR 112015011974A BR 112015011974 A8 BR112015011974 A8 BR 112015011974A8
- Authority
- BR
- Brazil
- Prior art keywords
- carboxamide derivatives
- medicament
- production
- pharmaceutical composition
- azaquinazoline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo patente de invenção: "derivados de azaquinazolina carboxamida". a presente invenção refere-se a novos derivados de azaquinazolina carboxamida de fórmula (i) (i) em que w1, w2, w3, w4, r1, r2, r3 e m que foram definidos acima, são inibidores de p70s6k, e podem ser empregados, inter alia, para o tratamento de distúrbios hiperproliferativos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261731075P | 2012-11-29 | 2012-11-29 | |
PCT/US2013/072141 WO2014085528A1 (en) | 2012-11-29 | 2013-11-27 | Azaquinazoline carboxamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015011974A2 BR112015011974A2 (pt) | 2017-07-11 |
BR112015011974A8 true BR112015011974A8 (pt) | 2019-10-08 |
Family
ID=49759613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015011974A BR112015011974A8 (pt) | 2012-11-29 | 2013-11-27 | derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica |
Country Status (19)
Country | Link |
---|---|
US (3) | US9440968B2 (pt) |
EP (1) | EP2925747B1 (pt) |
JP (1) | JP6290917B2 (pt) |
KR (1) | KR20150090044A (pt) |
CN (1) | CN105793254B (pt) |
AU (1) | AU2013352261B2 (pt) |
BR (1) | BR112015011974A8 (pt) |
CA (1) | CA2887539C (pt) |
CL (1) | CL2015001187A1 (pt) |
EA (2) | EA033655B1 (pt) |
ES (1) | ES2821102T3 (pt) |
IL (2) | IL239054B (pt) |
MX (1) | MX2015006516A (pt) |
NZ (1) | NZ706418A (pt) |
PE (1) | PE20151782A1 (pt) |
PH (2) | PH12015500712B1 (pt) |
SG (2) | SG10201800741QA (pt) |
UA (1) | UA115154C2 (pt) |
WO (1) | WO2014085528A1 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015006516A (es) * | 2012-11-29 | 2015-08-14 | Merck Patent Gmbh | Derivados de azaquinolin-carboxamida. |
JP6821670B2 (ja) | 2015-10-02 | 2021-01-27 | センティネル・オンコロジー・リミテッドSentinel Oncology Limited | 薬学的化合物 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
BR112022008131A2 (pt) | 2019-11-01 | 2022-07-19 | Syngenta Crop Protection Ag | Compostos heteroaromáticos bicíclicos fundidos pesticidamente ativos |
KR20240024926A (ko) | 2021-06-24 | 2024-02-26 | 신젠타 크롭 프로텍션 아게 | 살충제로서의 2-[3-[1[(퀴나졸린-4-일)아미노]에틸]피라진-2-일]티아졸-5-카르보니트릴 유도체 및 유사한 화합물 |
WO2023247360A1 (en) | 2022-06-21 | 2023-12-28 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
CN117304182A (zh) * | 2022-06-22 | 2023-12-29 | 上海海和药物研究开发股份有限公司 | 一类具有嘧啶并六元环结构的化合物、包含其的药物组合物及其应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA287539A (en) * | 1929-02-26 | William Hallden Karl | Severing apparatus | |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
JP2000505109A (ja) * | 1996-11-27 | 2000-04-25 | ファイザー・インク | 縮合二環式ピリミジン誘導体 |
TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
AU2003252314A1 (en) * | 2002-08-09 | 2004-02-25 | Kyorin Pharmaceutical Co., Ltd. | 4-substituted quinazoline-8-carboxyamide derivative and pharmaceutically acceptable addition salt thereof |
JP2006522124A (ja) | 2003-04-03 | 2006-09-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用な組成物 |
CA2539339A1 (en) | 2003-09-30 | 2005-04-14 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
JP4800216B2 (ja) | 2003-10-24 | 2011-10-26 | エグゼリクシス, インコーポレイテッド | p70S6キナーゼモジュレーターおよび使用方法 |
US20080262021A1 (en) | 2003-11-21 | 2008-10-23 | Novartis Ag | 1H-Imidazoquinoline Derivatives as Prote In Kinase Inhibitors |
ATE447957T1 (de) | 2003-12-09 | 2009-11-15 | Us Gov Health & Human Serv | Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen |
CA2563699C (en) | 2004-04-23 | 2014-03-25 | Exelixis, Inc. | Kinase modulators and method of use |
ATE543821T1 (de) | 2004-12-28 | 2012-02-15 | Exelixis Inc | Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen |
GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
WO2006136821A1 (en) | 2005-06-22 | 2006-12-28 | Astex Therapeutics Limited | Pharmaceutical compounds |
WO2007060404A1 (en) | 2005-11-22 | 2007-05-31 | Kudos Pharmaceuticals Limited | PYRIDO-,PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
CN101641358A (zh) | 2007-03-23 | 2010-02-03 | 霍夫曼-拉罗奇有限公司 | 氮杂-吡啶并嘧啶酮衍生物 |
UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
CN101230045B (zh) * | 2008-02-14 | 2013-04-10 | 沈阳药科大学 | 芳环并三嗪类衍生物及其应用 |
SG173473A1 (en) * | 2009-02-11 | 2011-09-29 | Merck Patent Gmbh | Novel amino azaheterocyclic carboxamides |
CN102858754A (zh) * | 2009-08-28 | 2013-01-02 | 阵列生物制药公司 | Raf抑制剂化合物及其使用方法 |
EA028012B1 (ru) * | 2010-07-29 | 2017-09-29 | Мерк Патент Гмбх | Циклический амин-азагетероциклический карбоксамид |
UA110113C2 (xx) * | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
EA023821B1 (ru) * | 2010-11-24 | 2016-07-29 | Мерк Патент Гмбх | Хиназолинкарбоксамидазетидины, их применение в лечении гиперпролиферативных заболеваний и содержащие их композиции |
US8791091B2 (en) | 2011-12-02 | 2014-07-29 | Bristol-Myers Squibb Company | Aryl dihydropyridinone and piperidinone MGAT2 inhibitors |
MX2015006516A (es) * | 2012-11-29 | 2015-08-14 | Merck Patent Gmbh | Derivados de azaquinolin-carboxamida. |
-
2013
- 2013-11-27 MX MX2015006516A patent/MX2015006516A/es unknown
- 2013-11-27 CN CN201380071357.2A patent/CN105793254B/zh not_active Expired - Fee Related
- 2013-11-27 KR KR1020157010463A patent/KR20150090044A/ko not_active Application Discontinuation
- 2013-11-27 JP JP2015545420A patent/JP6290917B2/ja not_active Expired - Fee Related
- 2013-11-27 EP EP13803403.8A patent/EP2925747B1/en active Active
- 2013-11-27 PE PE2015000693A patent/PE20151782A1/es active IP Right Grant
- 2013-11-27 NZ NZ70641813A patent/NZ706418A/en unknown
- 2013-11-27 UA UAA201506238A patent/UA115154C2/uk unknown
- 2013-11-27 US US14/432,618 patent/US9440968B2/en active Active
- 2013-11-27 BR BR112015011974A patent/BR112015011974A8/pt not_active Application Discontinuation
- 2013-11-27 AU AU2013352261A patent/AU2013352261B2/en not_active Ceased
- 2013-11-27 EA EA201792187A patent/EA033655B1/ru not_active IP Right Cessation
- 2013-11-27 CA CA2887539A patent/CA2887539C/en active Active
- 2013-11-27 EA EA201500573A patent/EA029144B1/ru not_active IP Right Cessation
- 2013-11-27 ES ES13803403T patent/ES2821102T3/es active Active
- 2013-11-27 SG SG10201800741QA patent/SG10201800741QA/en unknown
- 2013-11-27 SG SG11201502503RA patent/SG11201502503RA/en unknown
- 2013-11-27 WO PCT/US2013/072141 patent/WO2014085528A1/en active Application Filing
-
2015
- 2015-03-30 PH PH12015500712A patent/PH12015500712B1/en unknown
- 2015-05-05 CL CL2015001187A patent/CL2015001187A1/es unknown
- 2015-05-28 IL IL239054A patent/IL239054B/en active IP Right Grant
-
2016
- 2016-08-03 US US15/227,638 patent/US9981925B2/en active Active
- 2016-12-19 PH PH12016502534A patent/PH12016502534A1/en unknown
-
2017
- 2017-12-28 IL IL256646A patent/IL256646B/en active IP Right Grant
-
2018
- 2018-04-24 US US15/960,759 patent/US10233160B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112015011974A8 (pt) | derivados de azaquinazolina carboxamida, seus usos e processo para sua produção, medicamento e composição farmacêutica | |
BR112014026383A2 (pt) | derivados de benzamida para inibir a atividade de abl1, abl2 e bcr-abl1 | |
BR112014027584A2 (pt) | compostos e composições para inibir a atividade de abl1, abl2 e bcr-abl1 | |
BR112015001608A2 (pt) | inibidor lfa-1 e polimorfo do mesmo | |
EA201390934A1 (ru) | Композиции и способы модулирования fxr | |
BR112014027181A2 (pt) | derivados de benzamida para a inibição da atividade de abl1, abl2 e bcr-abl1 | |
BR112014030795A2 (pt) | composto, composição farmacêutica, uso de um composto e processo para preparação de um composto | |
BR112014001801A2 (pt) | indazóis | |
GEP201706780B (en) | Substituted 2-aza-bicyclo [2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c | |
GEP20146197B (en) | New compounds | |
BR112014023384A2 (pt) | inibidores de bace de di-hidro-tiazina e di-hidro-oxazina espirocíclicos, e composições e usos dos mesmos | |
EA201490493A1 (ru) | Пирано[3,2-d][1,3]тиазол в качестве ингибиторов гликозидазы | |
BR112014002675A2 (pt) | "quinazolina como inibidores de serina/treonina quinase, seus usos, e composição" | |
EA201201658A1 (ru) | Производные пиперидина и их применение для лечения метаболических нарушений | |
EA201690520A1 (ru) | Способ получения замещенных 5-фтор-1h-пиразолопиридинов | |
EA201300436A8 (ru) | Совместные кристаллы и соли ингибиторов ccr3 | |
BR112013020536A2 (pt) | 1,4-oxazepinas como inibidores de bace1 e/ou bace2 | |
PH12017500351A1 (en) | N-(2-(cyclic amine)ethyl)benzamide derivatives as p2x7 inhibitors | |
BRPI0808353B8 (pt) | usos de amidas do ácido 3-aril-3-hidróxi-2-amino-propiônico, amidas do ácido 3-heteroaril-3-hidróxi-2-amino-propiônico e compostos relacionados | |
EA201591180A1 (ru) | Составы ингибитора lfa-1 | |
BR112015006063A2 (pt) | compostos heteroaromáticos, processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica | |
BR112015001524A2 (pt) | composto, processo para a preparação de um composto, composição farmacêutica, método para o tratamento de déficits cognitivos e uso de um composto | |
MX2013006670A (es) | Derivado de 2-carboxamida-4-piperazinil-benzofurano. | |
MX2013011561A (es) | Compuestos de benzodioxepina y benzodioxina que interactuan con la proteina reguladora de glucocinasa para el tratamiento de diabetes. | |
MX2015006807A (es) | Metodo de preparacion de formas cristalinas de la 4-(ciclopropilmetoxi)-n-(3,5-dicloro-1-oxidopiridin-4-il)-5-metox ipiridin-2-carboxamida y sus formas cristalinas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |