EA201500573A1 - Производные азахиназолин карбоксамида - Google Patents
Производные азахиназолин карбоксамидаInfo
- Publication number
- EA201500573A1 EA201500573A1 EA201500573A EA201500573A EA201500573A1 EA 201500573 A1 EA201500573 A1 EA 201500573A1 EA 201500573 A EA201500573 A EA 201500573A EA 201500573 A EA201500573 A EA 201500573A EA 201500573 A1 EA201500573 A1 EA 201500573A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carboxamide
- derivatives
- azazhinazolin
- azahinazoline
- novel
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Новые производные азахиназолин карбоксамида формулы (I)где W, W, W, W, R, R, Rи m имеют значения, определенные выше, представляют собой p70S6K ингибитор и могут применяться, в частности, для лечения гиперпролиферативных нарушений.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261731075P | 2012-11-29 | 2012-11-29 | |
PCT/US2013/072141 WO2014085528A1 (en) | 2012-11-29 | 2013-11-27 | Azaquinazoline carboxamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201500573A1 true EA201500573A1 (ru) | 2016-02-29 |
EA029144B1 EA029144B1 (ru) | 2018-02-28 |
Family
ID=49759613
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792187A EA033655B1 (ru) | 2012-11-29 | 2013-11-27 | Производные азахиназолин карбоксамида |
EA201500573A EA029144B1 (ru) | 2012-11-29 | 2013-11-27 | Производные азахиназолин карбоксамида |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201792187A EA033655B1 (ru) | 2012-11-29 | 2013-11-27 | Производные азахиназолин карбоксамида |
Country Status (19)
Country | Link |
---|---|
US (3) | US9440968B2 (ru) |
EP (1) | EP2925747B1 (ru) |
JP (1) | JP6290917B2 (ru) |
KR (1) | KR20150090044A (ru) |
CN (1) | CN105793254B (ru) |
AU (1) | AU2013352261B2 (ru) |
BR (1) | BR112015011974A8 (ru) |
CA (1) | CA2887539C (ru) |
CL (1) | CL2015001187A1 (ru) |
EA (2) | EA033655B1 (ru) |
ES (1) | ES2821102T3 (ru) |
IL (2) | IL239054B (ru) |
MX (1) | MX2015006516A (ru) |
NZ (1) | NZ706418A (ru) |
PE (1) | PE20151782A1 (ru) |
PH (2) | PH12015500712A1 (ru) |
SG (2) | SG11201502503RA (ru) |
UA (1) | UA115154C2 (ru) |
WO (1) | WO2014085528A1 (ru) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA033655B1 (ru) * | 2012-11-29 | 2019-11-13 | Merck Patent Gmbh | Производные азахиназолин карбоксамида |
KR20180061318A (ko) | 2015-10-02 | 2018-06-07 | 센티넬 온콜로지 리미티드 | P70s6 키나제 억제제로서의 2-아미노퀴나졸린 유도체 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
IL291996A (en) | 2019-11-01 | 2022-06-01 | Syngenta Crop Protection Ag | Fused heteroaromatic bicyclic compounds are active as pesticides |
EP4359408A1 (en) | 2021-06-24 | 2024-05-01 | Syngenta Crop Protection AG | 2-[3-[1 [(quinazolin-4-yl)amino]ethyl]pyrazin-2-yl]thiazole-5-carbonitrile derivatives and similar compounds as pesticides |
WO2023247360A1 (en) | 2022-06-21 | 2023-12-28 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
CN117304182A (zh) * | 2022-06-22 | 2023-12-29 | 上海海和药物研究开发股份有限公司 | 一类具有嘧啶并六元环结构的化合物、包含其的药物组合物及其应用 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA287539A (en) * | 1929-02-26 | William Hallden Karl | Severing apparatus | |
IL112249A (en) * | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
IL129825A0 (en) | 1996-11-27 | 2000-02-29 | Pfizer | Fused bicyclic pyrimidine derivatives |
TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
AU2003252314A1 (en) | 2002-08-09 | 2004-02-25 | Kyorin Pharmaceutical Co., Ltd. | 4-substituted quinazoline-8-carboxyamide derivative and pharmaceutically acceptable addition salt thereof |
CA2522595A1 (en) | 2003-04-03 | 2004-10-28 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
US7189729B2 (en) | 2003-09-30 | 2007-03-13 | Irm Llc | Methods and compositions as protein kinase inhibitors |
JP4800216B2 (ja) | 2003-10-24 | 2011-10-26 | エグゼリクシス, インコーポレイテッド | p70S6キナーゼモジュレーターおよび使用方法 |
ATE400573T1 (de) | 2003-11-21 | 2008-07-15 | Novartis Pharma Gmbh | 1h-imidazochinolinderivate als proteinkinaseinhibitoren |
CA2546920A1 (en) | 2003-12-09 | 2005-06-23 | Joel Moss | Methods for suppressing an immune response or treating a proliferative disorder |
US8076338B2 (en) | 2004-04-23 | 2011-12-13 | Exelixis, Inc. | Kinase modulators and methods of use |
US7994172B2 (en) | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
JP2008546751A (ja) | 2005-06-22 | 2008-12-25 | アステックス・セラピューティクス・リミテッド | 医薬組成物 |
JP5161102B2 (ja) | 2005-11-22 | 2013-03-13 | クドス ファーマシューティカルズ リミテッド | mTOR阻害剤としてのピリドピリミジン、ピラゾピリミジンおよびピリミドピリミジン誘導体 |
EP2139895A1 (en) | 2007-03-23 | 2010-01-06 | F. Hoffmann-Roche AG | Aza-pyridopyrimidinone derivatives |
UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
CN101230045B (zh) * | 2008-02-14 | 2013-04-10 | 沈阳药科大学 | 芳环并三嗪类衍生物及其应用 |
PT2396307E (pt) * | 2009-02-11 | 2015-02-04 | Merck Patent Gmbh | Novas carboxamidas azaheterocíclicas de amino |
US20130018033A1 (en) * | 2009-08-28 | 2013-01-17 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
UA110113C2 (xx) * | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
SG186199A1 (en) * | 2010-07-29 | 2013-01-30 | Merck Patent Gmbh | Cyclic amine azaheterocyclic carboxamides |
PT2643313T (pt) | 2010-11-24 | 2016-10-11 | Merck Patent Gmbh | Quinazolina carboxamida azetidinas |
US8791091B2 (en) | 2011-12-02 | 2014-07-29 | Bristol-Myers Squibb Company | Aryl dihydropyridinone and piperidinone MGAT2 inhibitors |
EA033655B1 (ru) * | 2012-11-29 | 2019-11-13 | Merck Patent Gmbh | Производные азахиназолин карбоксамида |
-
2013
- 2013-11-27 EA EA201792187A patent/EA033655B1/ru not_active IP Right Cessation
- 2013-11-27 KR KR1020157010463A patent/KR20150090044A/ko not_active Application Discontinuation
- 2013-11-27 JP JP2015545420A patent/JP6290917B2/ja not_active Expired - Fee Related
- 2013-11-27 AU AU2013352261A patent/AU2013352261B2/en not_active Ceased
- 2013-11-27 ES ES13803403T patent/ES2821102T3/es active Active
- 2013-11-27 WO PCT/US2013/072141 patent/WO2014085528A1/en active Application Filing
- 2013-11-27 BR BR112015011974A patent/BR112015011974A8/pt not_active Application Discontinuation
- 2013-11-27 PE PE2015000693A patent/PE20151782A1/es active IP Right Grant
- 2013-11-27 EA EA201500573A patent/EA029144B1/ru not_active IP Right Cessation
- 2013-11-27 EP EP13803403.8A patent/EP2925747B1/en active Active
- 2013-11-27 CN CN201380071357.2A patent/CN105793254B/zh not_active Expired - Fee Related
- 2013-11-27 CA CA2887539A patent/CA2887539C/en active Active
- 2013-11-27 SG SG11201502503RA patent/SG11201502503RA/en unknown
- 2013-11-27 NZ NZ70641813A patent/NZ706418A/en unknown
- 2013-11-27 UA UAA201506238A patent/UA115154C2/uk unknown
- 2013-11-27 MX MX2015006516A patent/MX2015006516A/es unknown
- 2013-11-27 US US14/432,618 patent/US9440968B2/en active Active
- 2013-11-27 SG SG10201800741QA patent/SG10201800741QA/en unknown
-
2015
- 2015-03-30 PH PH12015500712A patent/PH12015500712A1/en unknown
- 2015-05-05 CL CL2015001187A patent/CL2015001187A1/es unknown
- 2015-05-28 IL IL239054A patent/IL239054B/en active IP Right Grant
-
2016
- 2016-08-03 US US15/227,638 patent/US9981925B2/en active Active
- 2016-12-19 PH PH12016502534A patent/PH12016502534B1/en unknown
-
2017
- 2017-12-28 IL IL256646A patent/IL256646B/en active IP Right Grant
-
2018
- 2018-04-24 US US15/960,759 patent/US10233160B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |