EA201301130A1 - Имидазопиридазины в качестве ингибиторов акт киназы - Google Patents

Имидазопиридазины в качестве ингибиторов акт киназы

Info

Publication number
EA201301130A1
EA201301130A1 EA201301130A EA201301130A EA201301130A1 EA 201301130 A1 EA201301130 A1 EA 201301130A1 EA 201301130 A EA201301130 A EA 201301130A EA 201301130 A EA201301130 A EA 201301130A EA 201301130 A1 EA201301130 A1 EA 201301130A1
Authority
EA
Eurasian Patent Office
Prior art keywords
imidazopiridazines
inhibitors kinase
kinase act
act
inhibitors
Prior art date
Application number
EA201301130A
Other languages
English (en)
Other versions
EA024890B1 (ru
Inventor
Ларс Берфаккер
Уилльям Джонстон Скотт
Андреа Хегебарт
Стьюарт Инс
Хартмут Ревинкель
Оливер Политц
Роланд Нойхаус
Ханс Брим
Ульф Бёмер
Original Assignee
Байер Интеллектчуал Проперти Гмбх
Байер Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Интеллектчуал Проперти Гмбх, Байер Фарма Акциенгезельшафт filed Critical Байер Интеллектчуал Проперти Гмбх
Publication of EA201301130A1 publication Critical patent/EA201301130A1/ru
Publication of EA024890B1 publication Critical patent/EA024890B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Имидазопиридазины формулы (I)способ их получения и их применение.
EA201301130A 2011-04-07 2012-04-05 Имидазопиридазины в качестве ингибиторов akt киназы EA024890B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161472732P 2011-04-07 2011-04-07
PCT/EP2012/056300 WO2012136776A1 (en) 2011-04-07 2012-04-05 Imidazopyridazines as akt kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201301130A1 true EA201301130A1 (ru) 2014-07-30
EA024890B1 EA024890B1 (ru) 2016-10-31

Family

ID=45953129

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201301130A EA024890B1 (ru) 2011-04-07 2012-04-05 Имидазопиридазины в качестве ингибиторов akt киназы

Country Status (42)

Country Link
US (2) US9206185B2 (ru)
EP (1) EP2694510B1 (ru)
JP (1) JP5906303B2 (ru)
KR (1) KR20140022057A (ru)
CN (1) CN103596957B (ru)
AP (1) AP3597A (ru)
AR (1) AR087148A1 (ru)
AU (1) AU2012238589B2 (ru)
BR (1) BR112013025777A2 (ru)
CA (1) CA2832374A1 (ru)
CL (1) CL2013002878A1 (ru)
CO (1) CO6862145A2 (ru)
CR (1) CR20130515A (ru)
CU (1) CU24263B1 (ru)
CY (1) CY1117163T1 (ru)
DK (1) DK2694510T3 (ru)
DO (1) DOP2013000226A (ru)
EA (1) EA024890B1 (ru)
EC (1) ECSP13013008A (ru)
ES (1) ES2558780T3 (ru)
GT (1) GT201300238A (ru)
HR (1) HRP20160011T1 (ru)
HU (1) HUE026323T2 (ru)
IL (1) IL228567A0 (ru)
JO (1) JO3068B1 (ru)
MA (1) MA35016B1 (ru)
ME (1) ME02316B (ru)
MX (1) MX336865B (ru)
NI (1) NI201300105A (ru)
PE (1) PE20141380A1 (ru)
PL (1) PL2694510T3 (ru)
PT (1) PT2694510E (ru)
RS (1) RS54480B1 (ru)
SG (1) SG193631A1 (ru)
SI (1) SI2694510T1 (ru)
SM (1) SMT201600001B (ru)
TN (1) TN2013000400A1 (ru)
TW (1) TWI535719B (ru)
UA (1) UA111739C2 (ru)
UY (1) UY34006A (ru)
WO (1) WO2012136776A1 (ru)
ZA (1) ZA201307223B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
PT2959900T (pt) 2008-06-16 2017-06-22 Univ Tennessee Res Found Composto para tratamento do cancro
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
MX2012010115A (es) 2010-03-01 2013-02-26 Gtx Inc Compuestos para el tratamiento de cancer.
EA024890B1 (ru) * 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы
JP6106694B2 (ja) * 2012-01-10 2017-04-05 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Ａｋｔキナーゼ阻害剤としての置換ピラゾロピリミジン類
CN104066735B (zh) * 2012-01-10 2016-08-31 拜耳知识产权有限责任公司 作为akt激酶抑制剂的取代的咪唑并吡嗪
CA2891346A1 (en) * 2012-11-30 2014-06-05 Gossett Campbell Pharmaceutical composition comprising trametinib dimethyl sulfoxide
CN109568312A (zh) * 2013-03-05 2019-04-05 田纳西大学研究基金会 用于治疗癌症的化合物
WO2014158467A1 (en) * 2013-03-12 2014-10-02 Glaxosmithkline Llc Combination
JP2016517434A (ja) * 2013-03-14 2016-06-16 エピザイム，インコーポレイティド 癌を処置するための併用療法
CN105899512A (zh) * 2014-01-09 2016-08-24 拜耳医药股份公司 可用于治疗过度增殖性和/或血管生成疾病的酰胺基团取代的咪唑并哒嗪
US10774086B2 (en) 2016-11-28 2020-09-15 Bristol-Myers Squibb Company GSK-3 inhibitors
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2002002582A0 (en) 1999-12-23 2002-09-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
ATE361297T1 (de) 2000-03-31 2007-05-15 Ortho Mcneil Pharm Inc Phenyl-substituierte imidazopyridine
CN1173975C (zh) 2000-04-27 2004-11-03 山之内制药株式会社 咪唑并吡啶衍生物
JP2006520796A (ja) 2003-03-17 2006-09-14 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼインヒビター
EP1622616B1 (en) 2003-04-24 2011-06-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
BRPI0412636A (pt) 2003-07-30 2006-09-26 S A L V A T Lab Sa imidazopirimidinas substituìdas para a prevenção e tratamento de cáncer
ATE499364T1 (de) 2004-04-09 2011-03-15 Merck Sharp & Dohme Hemmer der akt aktivität
US7544677B2 (en) 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
WO2006021303A1 (de) 2004-08-24 2006-03-02 Basf Aktiengesellschaft Imidazolium-methylsulfite als ausgangsverbindungen zur herstellung ionischer flüssigkeiten
EP1827436A4 (en) 2004-12-15 2011-08-10 Merck Sharp & Dohme ACTIVITY INHIBITORS AKT
JP2008540674A (ja) 2005-05-20 2008-11-20 アレイ バイオファーマ、インコーポレイテッド Ｒａｆ阻害化合物およびその使用方法
NZ563423A (en) 2005-06-10 2010-05-28 Merck Sharp & Dohme Inhibitors of AKT activity
US20070049591A1 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Inhibitors of MAPK/Erk Kinase
PE20070978A1 (es) 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
US7530313B2 (en) 2006-05-12 2009-05-12 Day & Zimmerman, Inc. Self-destruct fuze delay mechanism
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
KR20100032886A (ko) * 2007-06-08 2010-03-26 아보트 러보러터리즈 키나제 억제제로서의 5-헤테로아릴 치환된 인다졸
MX2010001746A (es) 2007-08-14 2010-03-10 Bayer Schering Pharma Ag Pirimidinas biciclicas fusionadas.
CN101835776A (zh) 2007-08-14 2010-09-15 拜耳先灵医药股份有限公司 用于癌症治疗的稠合的咪唑
BRPI0822240A2 (pt) 2007-12-21 2015-06-30 Wyeth Llc Composto imidazo [1,2-b] piridazina como moduladores de receptores x hepáticos
US8207169B2 (en) 2008-06-03 2012-06-26 Msd K.K. Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the formula D
US8536193B2 (en) 2008-06-03 2013-09-17 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
AR074072A1 (es) 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
PA8854101A1 (es) 2008-12-18 2010-07-27 Ortho Mcneil Janssen Pharm Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa
JP2012516847A (ja) 2009-02-02 2012-07-26 メルク・シャープ・エンド・ドーム・コーポレイション Ａｋｔ活性の阻害剤
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
US8614221B2 (en) 2009-03-11 2013-12-24 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
AR076936A1 (es) 2009-06-02 2011-07-20 Vitae Pharmaceuticals Inc Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1
WO2011033265A1 (en) * 2009-09-18 2011-03-24 Almac Discovery Limited Pharmaceutical compounds
ES2552841T3 (es) * 2010-07-12 2015-12-02 Bayer Intellectual Property Gmbh Imidazo[1,2-a]pirimidinas y -piridinas sustituidas
CA2806655A1 (en) 2010-07-28 2012-02-02 Bayer Intellectual Property Gmbh Substituted imidazo[1,2-b]pyridazines
EA024890B1 (ru) * 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы

Also Published As

Publication number Publication date
HUE026323T2 (en) 2016-05-30
AU2012238589B2 (en) 2017-02-16
MA35016B1 (fr) 2014-04-03
US20150368250A1 (en) 2015-12-24
EP2694510B1 (en) 2015-10-14
CN103596957A (zh) 2014-02-19
PT2694510E (pt) 2016-02-08
EA024890B1 (ru) 2016-10-31
ECSP13013008A (es) 2013-12-31
PL2694510T3 (pl) 2016-03-31
ZA201307223B (en) 2014-12-23
TW201245204A (en) 2012-11-16
ME02316B (me) 2016-06-20
CU20130135A7 (es) 2014-02-28
ES2558780T3 (es) 2016-02-08
GT201300238A (es) 2015-04-06
JO3068B1 (ar) 2017-03-15
AP3597A (en) 2016-02-19
DK2694510T3 (en) 2016-01-18
CN103596957B (zh) 2016-12-07
SMT201600001B (it) 2016-02-25
CA2832374A1 (en) 2012-10-11
RS54480B1 (en) 2016-06-30
HRP20160011T1 (hr) 2016-02-12
TN2013000400A1 (en) 2015-03-30
WO2012136776A1 (en) 2012-10-11
CR20130515A (es) 2013-12-04
CO6862145A2 (es) 2014-02-10
US9604989B2 (en) 2017-03-28
KR20140022057A (ko) 2014-02-21
NZ616270A (en) 2015-09-25
SG193631A1 (en) 2013-11-29
JP5906303B2 (ja) 2016-04-20
CY1117163T1 (el) 2017-04-05
AP2013007215A0 (en) 2013-10-31
TWI535719B (zh) 2016-06-01
EP2694510A1 (en) 2014-02-12
US9206185B2 (en) 2015-12-08
AR087148A1 (es) 2014-02-26
PE20141380A1 (es) 2014-10-18
UA111739C2 (uk) 2016-06-10
SI2694510T1 (sl) 2016-02-29
CU24263B1 (es) 2017-07-04
DOP2013000226A (es) 2013-11-15
MX336865B (es) 2016-02-04
IL228567A0 (en) 2013-12-31
BR112013025777A2 (pt) 2016-12-20
JP2014510127A (ja) 2014-04-24
US20140113901A1 (en) 2014-04-24
NI201300105A (es) 2014-07-14
UY34006A (es) 2012-10-31
MX2013011699A (es) 2014-01-31
CL2013002878A1 (es) 2014-05-02
AU2012238589A1 (en) 2013-11-07

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU