MA35016B1 - Imidazopyridazines en gtant qu'inhibiteurs de la kinase akt - Google Patents
Imidazopyridazines en gtant qu'inhibiteurs de la kinase aktInfo
- Publication number
- MA35016B1 MA35016B1 MA36290A MA36290A MA35016B1 MA 35016 B1 MA35016 B1 MA 35016B1 MA 36290 A MA36290 A MA 36290A MA 36290 A MA36290 A MA 36290A MA 35016 B1 MA35016 B1 MA 35016B1
- Authority
- MA
- Morocco
- Prior art keywords
- imidazopyridazines
- akt inhibitors
- kinase akt
- kinase
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des imidazopyridazines de la formule (I) et un procédé pour leur fabrication et leur utilisation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161472732P | 2011-04-07 | 2011-04-07 | |
PCT/EP2012/056300 WO2012136776A1 (fr) | 2011-04-07 | 2012-04-05 | Imidazopyridazines en tant qu'inhibiteurs de la kinase akt |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35016B1 true MA35016B1 (fr) | 2014-04-03 |
Family
ID=45953129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36290A MA35016B1 (fr) | 2011-04-07 | 2012-04-05 | Imidazopyridazines en gtant qu'inhibiteurs de la kinase akt |
Country Status (42)
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3289876T (pt) | 2008-06-16 | 2022-10-28 | Univ Tennessee Res Found | Compostos para o tratamento do câncer |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
RU2581367C2 (ru) | 2010-03-01 | 2016-04-20 | Джи Ти Икс, ИНК. | Соединения для лечения рака |
US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
ME02316B (me) * | 2011-04-07 | 2016-06-20 | Bayer Ip Gmbh | Imidazopiridazini kao inhibitori akt kinaze |
EP2802588B1 (fr) * | 2012-01-10 | 2016-05-25 | Bayer Intellectual Property GmbH | Pyrazolopyrimidines substituées comme inhibiteurs de kinase akt |
JP6088542B2 (ja) * | 2012-01-10 | 2017-03-01 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | Aktキナーゼ阻害剤としての置換イミダゾピラジン類 |
EA028246B1 (ru) * | 2012-11-30 | 2017-10-31 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Фармацевтическая композиция |
CA2904338C (fr) | 2013-03-05 | 2022-07-05 | University Of Tennessee Research Foundation | Utilisation de derives de l'imidazole conjointement a un inhibiteur brafou a un inhibiteur mek dans le traitement du cancer |
WO2014158467A1 (fr) * | 2013-03-12 | 2014-10-02 | Glaxosmithkline Llc | Combinaison |
JP2016517434A (ja) * | 2013-03-14 | 2016-06-16 | エピザイム,インコーポレイティド | 癌を処置するための併用療法 |
EP3092242A1 (fr) * | 2014-01-09 | 2016-11-16 | Bayer Pharma Aktiengesellschaft | Imidazopyridazines amido-substituées utiles dans le traitement des troubles hyperprolifératifs et/ou de l'angiogenèse |
MA46888A (fr) * | 2016-11-28 | 2021-06-02 | Bristol Myers Squibb Co | Inhibiteurs de gsk-3 |
EP3453706A1 (fr) | 2017-09-08 | 2019-03-13 | Basf Se | Composés pesticides de l'imizazole |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2393724A1 (fr) | 1999-12-23 | 2001-06-28 | Nitromed, Inc. | Inhibiteurs de cyclooxygenase-2 nitroses et nitrosyles, compositions et procedes d'utilisation |
WO2001074815A2 (fr) | 2000-03-31 | 2001-10-11 | Ortho Mcneil Pharmaceutical, Inc. | Imidazopyridines phenyle-substituees |
DK1277754T3 (da) | 2000-04-27 | 2005-11-14 | Astellas Pharma Inc | Imidazopyridinderivater |
CA2518318A1 (fr) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Inhibiteurs d'histone deacetylase |
CN1809354A (zh) | 2003-04-24 | 2006-07-26 | 麦克公司 | Akt活性抑制剂 |
CA2534292A1 (fr) | 2003-07-30 | 2005-02-17 | Laboratorios S.A.L.V.A.T., S.A. | Imidazopyrimidines substituees pour la prevention et le traitement du cancer |
CA2561311A1 (fr) | 2004-04-09 | 2005-10-27 | Merck & Co., Inc. | Inhibiteurs de l'activite d'akt |
CN101217958A (zh) | 2004-08-23 | 2008-07-09 | 默克公司 | Akt活性抑制剂 |
EP1786780A1 (fr) | 2004-08-24 | 2007-05-23 | Basf Aktiengesellschaft | Sulfites d'imidazolium-methyle utilises comme composes de depart ausgangsverbindungen pour la production de liquides ioniques |
US7910561B2 (en) | 2004-12-15 | 2011-03-22 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
EP1902056A2 (fr) | 2005-05-20 | 2008-03-26 | Array Biopharma, Inc. | Composes inhibiteurs raf et procedes d'utilisation de ceux-ci |
CA2610888C (fr) | 2005-06-10 | 2011-02-08 | Merck & Co., Inc. | Inhibiteurs de l'activite akt |
US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
PE20070978A1 (es) | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
US7530313B2 (en) | 2006-05-12 | 2009-05-12 | Day & Zimmerman, Inc. | Self-destruct fuze delay mechanism |
AR064010A1 (es) * | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
AU2008262038A1 (en) * | 2007-06-08 | 2008-12-18 | AbbVie Deutschland GmbH & Co. KG | 5-heteroaryl substituted indazoles as kinase inhibitors |
JP5327652B2 (ja) * | 2007-08-14 | 2013-10-30 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 癌処理のための融合されたイミダゾール |
RS52559B (en) | 2007-08-14 | 2013-04-30 | Bayer Intellectual Property Gmbh | FUSIONED BICYCLIC PYRIMIDINES |
WO2009086130A1 (fr) | 2007-12-21 | 2009-07-09 | Wyeth | Composés d'imidazo-[1,2-b]-pyridazine comme modulateurs des récepteurs x du foie |
CA2726358A1 (fr) | 2008-06-03 | 2009-12-10 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'activite akt |
US8207169B2 (en) | 2008-06-03 | 2012-06-26 | Msd K.K. | Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the formula D |
AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
PA8854101A1 (es) | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
CA2750051A1 (fr) | 2009-02-02 | 2010-08-05 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'activite d'akt |
CN102317291B (zh) * | 2009-02-13 | 2015-02-11 | 拜耳知识产权有限责任公司 | 稠合嘧啶 |
WO2010104933A1 (fr) | 2009-03-11 | 2010-09-16 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'activité akt |
WO2010114780A1 (fr) * | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de l'activité akt |
AR076936A1 (es) | 2009-06-02 | 2011-07-20 | Vitae Pharmaceuticals Inc | Inhibidores de carbamato y urea de la 11 beta hidroxiesteroide deshidrogenasa 1 |
WO2011033265A1 (fr) * | 2009-09-18 | 2011-03-24 | Almac Discovery Limited | Composés pharmaceutiques |
CN103097384B (zh) | 2010-07-12 | 2017-02-15 | 拜耳知识产权有限责任公司 | 取代的咪唑并[1,2‑a]嘧啶和吡啶 |
JP5926727B2 (ja) * | 2010-07-28 | 2016-05-25 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 置換イミダゾ[1,2−b]ピリダジン |
ME02316B (me) * | 2011-04-07 | 2016-06-20 | Bayer Ip Gmbh | Imidazopiridazini kao inhibitori akt kinaze |
-
2012
- 2012-04-05 ME MEP-2016-1A patent/ME02316B/me unknown
- 2012-04-05 RS RS20160005A patent/RS54480B1/en unknown
- 2012-04-05 SG SG2013072509A patent/SG193631A1/en unknown
- 2012-04-05 KR KR1020137029229A patent/KR20140022057A/ko not_active Application Discontinuation
- 2012-04-05 EP EP12713963.2A patent/EP2694510B1/fr active Active
- 2012-04-05 HU HUE12713963A patent/HUE026323T2/en unknown
- 2012-04-05 BR BR112013025777A patent/BR112013025777A2/pt active Search and Examination
- 2012-04-05 WO PCT/EP2012/056300 patent/WO2012136776A1/fr active Application Filing
- 2012-04-05 PL PL12713963T patent/PL2694510T3/pl unknown
- 2012-04-05 PE PE2013002192A patent/PE20141380A1/es not_active Application Discontinuation
- 2012-04-05 EA EA201301130A patent/EA024890B1/ru not_active IP Right Cessation
- 2012-04-05 MA MA36290A patent/MA35016B1/fr unknown
- 2012-04-05 PT PT127139632T patent/PT2694510E/pt unknown
- 2012-04-05 JO JOP/2012/0084A patent/JO3068B1/ar active
- 2012-04-05 AU AU2012238589A patent/AU2012238589B2/en not_active Ceased
- 2012-04-05 JP JP2014503153A patent/JP5906303B2/ja not_active Expired - Fee Related
- 2012-04-05 ES ES12713963.2T patent/ES2558780T3/es active Active
- 2012-04-05 MX MX2013011699A patent/MX336865B/es active IP Right Grant
- 2012-04-05 SI SI201230430T patent/SI2694510T1/sl unknown
- 2012-04-05 CN CN201280027994.5A patent/CN103596957B/zh not_active Expired - Fee Related
- 2012-04-05 US US14/007,427 patent/US9206185B2/en not_active Expired - Fee Related
- 2012-04-05 DK DK12713963.2T patent/DK2694510T3/en active
- 2012-04-05 AP AP2013007215A patent/AP3597A/xx active
- 2012-04-05 CU CUP2013000135A patent/CU24263B1/es unknown
- 2012-04-05 CA CA2832374A patent/CA2832374A1/fr not_active Abandoned
- 2012-04-06 TW TW101112356A patent/TWI535719B/zh not_active IP Right Cessation
- 2012-04-09 AR ARP120101200A patent/AR087148A1/es active Pending
- 2012-04-09 UY UY0001034006A patent/UY34006A/es not_active Application Discontinuation
- 2012-05-04 UA UAA201312894A patent/UA111739C2/uk unknown
-
2013
- 2013-09-26 ZA ZA2013/07223A patent/ZA201307223B/en unknown
- 2013-09-29 IL IL228567A patent/IL228567A0/en unknown
- 2013-10-03 TN TNP2013000400A patent/TN2013000400A1/fr unknown
- 2013-10-07 GT GT201300238A patent/GT201300238A/es unknown
- 2013-10-07 NI NI201300105A patent/NI201300105A/es unknown
- 2013-10-07 CO CO13237923A patent/CO6862145A2/es active IP Right Grant
- 2013-10-07 DO DO2013000226A patent/DOP2013000226A/es unknown
- 2013-10-07 CR CR20130515A patent/CR20130515A/es unknown
- 2013-10-07 CL CL2013002878A patent/CL2013002878A1/es unknown
- 2013-11-04 EC ECSP13013008 patent/ECSP13013008A/es unknown
-
2015
- 2015-07-06 US US14/792,205 patent/US9604989B2/en not_active Expired - Fee Related
-
2016
- 2016-01-05 SM SM201600001T patent/SMT201600001B/it unknown
- 2016-01-05 HR HRP20160011TT patent/HRP20160011T1/hr unknown
- 2016-01-08 CY CY20161100011T patent/CY1117163T1/el unknown
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