CR20130515A - Imidazopiridazinas como inhibidores de quinasa akt - Google Patents

Imidazopiridazinas como inhibidores de quinasa akt

Info

Publication number
CR20130515A
CR20130515A CR20130515A CR20130515A CR20130515A CR 20130515 A CR20130515 A CR 20130515A CR 20130515 A CR20130515 A CR 20130515A CR 20130515 A CR20130515 A CR 20130515A CR 20130515 A CR20130515 A CR 20130515A
Authority
CR
Costa Rica
Prior art keywords
imidazopiridazinas
quinasa
akt inhibitors
akt
inhibitors
Prior art date
Application number
CR20130515A
Other languages
English (en)
Inventor
Lars Bärfacker
William Johnston Scott
Andrea Hägebarth
Stuart Ince
Hartmut Rehwinkel
Oliver Politz
Roland Neuhaus
Hans Briem
Ulf Bömer
Original Assignee
Bayer Pharma AG
Bayer Shering Pharma Ag
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG, Bayer Shering Pharma Ag, Bayer Ip Gmbh filed Critical Bayer Pharma AG
Publication of CR20130515A publication Critical patent/CR20130515A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Imidazopiridazinas de fórmula (I), un proceso para su producción y el uso de las mismas.
CR20130515A 2011-04-07 2013-10-07 Imidazopiridazinas como inhibidores de quinasa akt CR20130515A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161472732P 2011-04-07 2011-04-07

Publications (1)

Publication Number Publication Date
CR20130515A true CR20130515A (es) 2013-12-04

Family

ID=45953129

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130515A CR20130515A (es) 2011-04-07 2013-10-07 Imidazopiridazinas como inhibidores de quinasa akt

Country Status (42)

Country Link
US (2) US9206185B2 (es)
EP (1) EP2694510B1 (es)
JP (1) JP5906303B2 (es)
KR (1) KR20140022057A (es)
CN (1) CN103596957B (es)
AP (1) AP3597A (es)
AR (1) AR087148A1 (es)
AU (1) AU2012238589B2 (es)
BR (1) BR112013025777A2 (es)
CA (1) CA2832374A1 (es)
CL (1) CL2013002878A1 (es)
CO (1) CO6862145A2 (es)
CR (1) CR20130515A (es)
CU (1) CU24263B1 (es)
CY (1) CY1117163T1 (es)
DK (1) DK2694510T3 (es)
DO (1) DOP2013000226A (es)
EA (1) EA024890B1 (es)
EC (1) ECSP13013008A (es)
ES (1) ES2558780T3 (es)
GT (1) GT201300238A (es)
HR (1) HRP20160011T1 (es)
HU (1) HUE026323T2 (es)
IL (1) IL228567A0 (es)
JO (1) JO3068B1 (es)
MA (1) MA35016B1 (es)
ME (1) ME02316B (es)
MX (1) MX336865B (es)
NI (1) NI201300105A (es)
PE (1) PE20141380A1 (es)
PL (1) PL2694510T3 (es)
PT (1) PT2694510E (es)
RS (1) RS54480B1 (es)
SG (1) SG193631A1 (es)
SI (1) SI2694510T1 (es)
SM (1) SMT201600001B (es)
TN (1) TN2013000400A1 (es)
TW (1) TWI535719B (es)
UA (1) UA111739C2 (es)
UY (1) UY34006A (es)
WO (1) WO2012136776A1 (es)
ZA (1) ZA201307223B (es)

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EP3289876B1 (en) 2008-06-16 2022-07-20 University of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
AU2010347233B2 (en) 2010-03-01 2015-06-18 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
US11084811B2 (en) 2010-03-01 2021-08-10 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
ME02316B (me) * 2011-04-07 2016-06-20 Bayer Ip Gmbh Imidazopiridazini kao inhibitori akt kinaze
EP2802588B1 (en) * 2012-01-10 2016-05-25 Bayer Intellectual Property GmbH Substituted pyrazolopyrimidines as akt kinase inhibitors
EP2802586B1 (en) * 2012-01-10 2016-05-25 Bayer Intellectual Property GmbH Substituted imidazopyrazines as akt kinase inhibitors
EP3400933A1 (en) * 2012-11-30 2018-11-14 Novartis AG Novel pharmaceutical trametinib composition
JP6835472B2 (ja) 2013-03-05 2021-02-24 ユニバーシティ オブ テネシー リサーチ ファウンデーション 癌の処置のための組成物
US20150352121A1 (en) * 2013-03-12 2015-12-10 Glaxosmithkline Llc Combination
AU2014236348B2 (en) * 2013-03-14 2018-05-10 Epizyme, Inc. Combination therapy for treating cancer
WO2015104254A1 (en) * 2014-01-09 2015-07-16 Bayer Pharma Aktiengesellschaft Amido-substituted imidazopyridazines useful in the treatment of hyper-proliferative and/or angiogenesis disorders
EP3544980B1 (en) * 2016-11-28 2021-10-13 Bristol-Myers Squibb Company Gsk-3 inhibitors
EP3453706A1 (en) 2017-09-08 2019-03-13 Basf Se Pesticidal imidazole compounds

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DE60128211T2 (de) 2000-03-31 2008-01-10 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituierte imidazopyridine
CA2407573C (en) 2000-04-27 2011-09-13 Yamanouchi Pharmaceutical Co. Ltd. Imidazopyridine derivatives
WO2004082638A2 (en) 2003-03-17 2004-09-30 Syrrx, Inc. Histone deacetylase inhibitors
ATE512957T1 (de) 2003-04-24 2011-07-15 Merck Sharp & Dohme Hemmer der akt aktivität
AU2004263297A1 (en) 2003-07-30 2005-02-17 Laboratorios S.A.L.V.A.T., S.A. Substituted imidazopyrimidines for the prevention and treatment of cancer
US7655649B2 (en) 2004-04-09 2010-02-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
WO2006036395A2 (en) 2004-08-23 2006-04-06 Merck & Co., Inc. Inhibitors of akt activity
EP1786780A1 (de) 2004-08-24 2007-05-23 Basf Aktiengesellschaft Imidazolium-methylsulfite als ausgangsverbindungen zur herstellung ionischer flüssigkeiten
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CN101263142A (zh) 2005-05-20 2008-09-10 阿雷生物药品公司 Raf抑制剂化合物及其使用方法
PT1898903E (pt) 2005-06-10 2013-06-28 Merck Sharp & Dohme Inibidores da atividade de akt
US20070049591A1 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Inhibitors of MAPK/Erk Kinase
PE20070978A1 (es) 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
US7530313B2 (en) 2006-05-12 2009-05-12 Day & Zimmerman, Inc. Self-destruct fuze delay mechanism
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt
EP2167491A1 (en) * 2007-06-08 2010-03-31 Abbott Laboratories 5-heteroaryl substituted indazoles as kinase inhibitors
ATE503757T1 (de) * 2007-08-14 2011-04-15 Bayer Schering Pharma Ag Kondensierte imidazole zur krebsbehandlung
UY31293A1 (es) 2007-08-14 2009-03-31 Pirimidinas biciclicas fusionadas
US20100331333A1 (en) 2007-12-21 2010-12-30 Wyeth Llc Imidazo [1,2-B] Pyridazine Compounds
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ME02316B (me) * 2011-04-07 2016-06-20 Bayer Ip Gmbh Imidazopiridazini kao inhibitori akt kinaze

Also Published As

Publication number Publication date
TN2013000400A1 (en) 2015-03-30
AU2012238589A1 (en) 2013-11-07
CA2832374A1 (en) 2012-10-11
CO6862145A2 (es) 2014-02-10
IL228567A0 (en) 2013-12-31
NZ616270A (en) 2015-09-25
UA111739C2 (uk) 2016-06-10
ECSP13013008A (es) 2013-12-31
ZA201307223B (en) 2014-12-23
SG193631A1 (en) 2013-11-29
JO3068B1 (ar) 2017-03-15
EA201301130A1 (ru) 2014-07-30
UY34006A (es) 2012-10-31
TW201245204A (en) 2012-11-16
PE20141380A1 (es) 2014-10-18
HRP20160011T1 (hr) 2016-02-12
AP2013007215A0 (en) 2013-10-31
AP3597A (en) 2016-02-19
PL2694510T3 (pl) 2016-03-31
MX336865B (es) 2016-02-04
CN103596957A (zh) 2014-02-19
WO2012136776A1 (en) 2012-10-11
SMT201600001B (it) 2016-02-25
US9604989B2 (en) 2017-03-28
US20140113901A1 (en) 2014-04-24
CU20130135A7 (es) 2014-02-28
RS54480B1 (en) 2016-06-30
ES2558780T3 (es) 2016-02-08
KR20140022057A (ko) 2014-02-21
CL2013002878A1 (es) 2014-05-02
TWI535719B (zh) 2016-06-01
CN103596957B (zh) 2016-12-07
AR087148A1 (es) 2014-02-26
DK2694510T3 (en) 2016-01-18
US20150368250A1 (en) 2015-12-24
AU2012238589B2 (en) 2017-02-16
BR112013025777A2 (pt) 2016-12-20
PT2694510E (pt) 2016-02-08
EA024890B1 (ru) 2016-10-31
EP2694510A1 (en) 2014-02-12
NI201300105A (es) 2014-07-14
US9206185B2 (en) 2015-12-08
HUE026323T2 (en) 2016-05-30
MX2013011699A (es) 2014-01-31
SI2694510T1 (sl) 2016-02-29
JP2014510127A (ja) 2014-04-24
EP2694510B1 (en) 2015-10-14
CU24263B1 (es) 2017-07-04
MA35016B1 (fr) 2014-04-03
GT201300238A (es) 2015-04-06
JP5906303B2 (ja) 2016-04-20
ME02316B (me) 2016-06-20
CY1117163T1 (el) 2017-04-05
DOP2013000226A (es) 2013-11-15

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