CL2012000590A1 - Proceso para preparar w-transaminasa (r)-selectiva. - Google Patents

Proceso para preparar w-transaminasa (r)-selectiva.

Info

Publication number
CL2012000590A1
CL2012000590A1 CL2012000590A CL2012000590A CL2012000590A1 CL 2012000590 A1 CL2012000590 A1 CL 2012000590A1 CL 2012000590 A CL2012000590 A CL 2012000590A CL 2012000590 A CL2012000590 A CL 2012000590A CL 2012000590 A1 CL2012000590 A1 CL 2012000590A1
Authority
CL
Chile
Prior art keywords
transaminase
selective
prepare
Prior art date
Application number
CL2012000590A
Other languages
English (en)
Inventor
Mattias Hoehne
Uwe Bornscheuer
Karen Robins
Sebastian Schaetzle
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of CL2012000590A1 publication Critical patent/CL2012000590A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search

Abstract

Proceso para preparar W-transaminasa (R)-selectiva.
CL2012000590A 2009-09-02 2012-03-02 Proceso para preparar w-transaminasa (r)-selectiva. CL2012000590A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09011271 2009-09-02
EP10005203 2010-05-19

Publications (1)

Publication Number Publication Date
CL2012000590A1 true CL2012000590A1 (es) 2012-08-17

Family

ID=42733750

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012000590A CL2012000590A1 (es) 2009-09-02 2012-03-02 Proceso para preparar w-transaminasa (r)-selectiva.

Country Status (17)

Country Link
US (1) US8577622B2 (es)
EP (3) EP2857505B1 (es)
JP (3) JP5792728B2 (es)
KR (1) KR101698435B1 (es)
CN (3) CN102482650B (es)
AU (1) AU2010291586C1 (es)
BR (1) BR112012004817A2 (es)
CA (1) CA2772426A1 (es)
CL (1) CL2012000590A1 (es)
EA (1) EA022764B1 (es)
ES (2) ES2562458T3 (es)
HK (2) HK1165831A1 (es)
IL (3) IL218397A0 (es)
MX (1) MX2012002561A (es)
SG (1) SG178842A1 (es)
WO (1) WO2011026556A1 (es)
ZA (1) ZA201200625B (es)

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US8470564B2 (en) 2009-01-08 2013-06-25 Codexis, Inc. Transaminase polypeptides
CN102405281B (zh) 2009-02-26 2015-05-13 科德克希思公司 转氨酶生物催化剂
EP2446026B1 (en) 2009-06-22 2017-08-09 Codexis, Inc. Transaminase reactions
WO2011159910A2 (en) 2010-06-17 2011-12-22 Codexis, Inc. Biocatalysts and methods for the synthesis of (s)-3-(1-aminoethyl)-phenol
US20140199734A1 (en) 2010-07-14 2014-07-17 Dsm Ip Assets B.V. (r)- selective amination
KR101469855B1 (ko) * 2013-03-26 2014-12-09 연세대학교 산학협력단 오메가-트랜스아미나제를 이용한 d-아미노산의 비대칭 생산 방법
JP6367944B2 (ja) * 2013-11-26 2018-08-01 ▲凱▼菜英医▲薬▼集▲団▼（天津）股▲フン▼有限公司 トランスアミナーゼ及びその応用
CN105018440B (zh) * 2014-04-24 2018-06-05 上海弈柯莱生物医药科技有限公司 一种转氨酶及其在合成西他列汀中间体中的应用
CN105950581B (zh) * 2016-06-21 2019-11-19 浙江科技学院 一种引入二硫键的ω-转氨酶突变体及其应用
CN106754806B (zh) * 2016-12-20 2020-04-14 尚科生物医药（上海）有限公司 一种改进的转氨酶及其在(r)-3-氨基丁醇制备上的应用
CN110088079A (zh) * 2016-12-23 2019-08-02 诺华股份有限公司 用于早期沙卡布曲中间体的新方法
CN107384887B (zh) * 2017-07-05 2020-08-21 浙江工业大学 一种氨基转移酶、突变体及其制备西他列汀的应用
CN109234327A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种立体选择性的转氨酶在不对称合成手性胺中的应用
CN107586884B (zh) * 2017-10-25 2020-08-18 东北农业大学 一种用于猫传染性腹膜炎病毒检测的rt-pcr引物组，含有该引物组的试剂盒及其应用
ES2816102T3 (es) * 2017-11-17 2021-03-31 Enzymicals Ag Procedimiento de preparación de aminas a partir de compuestos de carbonilo mediante reacción de transaminasa bajo precipitación de sal
CN109957554B (zh) * 2017-12-26 2021-05-07 宁波酶赛生物工程有限公司 工程化转氨酶多肽及其应用
CN108866021B (zh) * 2018-05-30 2021-06-08 浙江工业大学 一种转氨酶突变体及在制备西他列汀中间体中的应用
CN109576238A (zh) * 2018-11-12 2019-04-05 太原理工大学 一种重组转氨酶及其在不对称胺化α-羟酮制备手性β-氨基醇中的应用
CN109486784B (zh) * 2018-11-30 2020-06-09 江南大学 一种能催化西他沙星五元环关键中间体的ω-转氨酶突变体
CN112522229B (zh) * 2020-10-26 2021-07-27 浙江工业大学 转氨酶突变体及其在制备西他列汀中间体中的应用
CN112481229B (zh) * 2020-11-25 2022-12-30 华东理工大学 一种ω转氨酶及其突变体、重组质粒、基因工程菌及其应用
CN113881647B (zh) * 2020-12-28 2023-11-17 上海合全药物研发有限公司 转氨酶及其在制备光学纯手性胺中的应用
CN114875005B (zh) * 2021-02-05 2023-11-24 上海交通大学 一种对映选择性翻转的ω-转氨酶突变体的构建及应用
CN114134128B (zh) * 2021-12-07 2023-05-23 浙江科技学院 一种基于祖先序列重建的ω-转氨酶突变体
CN114645030B (zh) * 2022-04-08 2023-11-17 浙江科技学院 一种ω-转氨酶突变体及其在制备西塞卡纳药物中间体的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58135000A (ja) * 1982-02-02 1983-08-11 Yokogawa Hokushin Electric Corp グルタミン酸オキサロ酢酸トランスアミナ−ゼおよびグルタミン酸ピルビン酸トランスアミナ−ゼの測定方法および測定装置
US20020132295A1 (en) * 1996-02-09 2002-09-19 Short Jay M. Enzymes having transaminase and aminotransferase activity and methods of use thereof
JP4213771B2 (ja) * 1997-04-23 2009-01-21 株式会社カネカ 光学活性アミノ化合物の製造方法
CZ295882B6 (cs) * 1998-03-11 2005-11-16 Celgro Způsob zlepšení enzymatické syntézy chirálních aminů
ATE277170T1 (de) 1999-03-19 2004-10-15 Sumitomo Chemical Co Stereoselektive transaminase, deren kodierende gen und deren verwendungen
EP1818411A1 (en) * 2006-02-13 2007-08-15 Lonza AG Process for the preparation of optically active chiral amines
CN101965397B (zh) * 2008-01-03 2016-09-28 巴斯夫酶有限责任公司 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法
CN101250229B (zh) * 2008-03-05 2012-05-30 天津市血液中心 丙氨酸氨基转移酶单克隆抗体及其用途

Also Published As

Publication number Publication date
AU2010291586B2 (en) 2015-01-22
EP2862938A2 (en) 2015-04-22
ZA201200625B (en) 2013-05-29
CN102482650A (zh) 2012-05-30
EP2473601B1 (en) 2015-12-02
IL218397A0 (en) 2012-04-30
JP2015130865A (ja) 2015-07-23
JP6033900B2 (ja) 2016-11-30
EP2857505B1 (en) 2016-10-19
HK1165831A1 (en) 2012-10-12
EP2857505A2 (en) 2015-04-08
EP2473601A1 (en) 2012-07-11
JP2015121557A (ja) 2015-07-02
EP2857505A3 (en) 2015-07-01
ES2562458T3 (es) 2016-03-04
CA2772426A1 (en) 2011-03-10
US8577622B2 (en) 2013-11-05
IL237444A0 (en) 2015-04-30
ES2599644T3 (es) 2017-02-02
BR112012004817A2 (pt) 2015-09-01
HK1203562A1 (en) 2015-10-30
KR20120096465A (ko) 2012-08-30
CN104480155B (zh) 2019-03-01
CN103472093A (zh) 2013-12-25
CN102482650B (zh) 2014-12-17
CN104480155A (zh) 2015-04-01
WO2011026556A1 (en) 2011-03-10
SG178842A1 (en) 2012-04-27
AU2010291586A1 (en) 2012-03-01
AU2010291586C1 (en) 2015-04-16
KR101698435B1 (ko) 2017-01-20
IL237445A0 (en) 2015-04-30
MX2012002561A (es) 2012-04-10
EP2862938A3 (en) 2015-07-15
JP2013503610A (ja) 2013-02-04
EA201270350A1 (ru) 2012-07-30
JP5792728B2 (ja) 2015-10-14
US20120156706A1 (en) 2012-06-21
EA022764B1 (ru) 2016-02-29

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