CL2012002082A1 - Proceso para la preparacion de lacosamida, por hidroximetilación; compuestos intermediarios. - Google Patents

Proceso para la preparacion de lacosamida, por hidroximetilación; compuestos intermediarios.

Info

Publication number
CL2012002082A1
CL2012002082A1 CL2012002082A CL2012002082A CL2012002082A1 CL 2012002082 A1 CL2012002082 A1 CL 2012002082A1 CL 2012002082 A CL2012002082 A CL 2012002082A CL 2012002082 A CL2012002082 A CL 2012002082A CL 2012002082 A1 CL2012002082 A1 CL 2012002082A1
Authority
CL
Chile
Prior art keywords
hydroxymethylation
lacosamide
preparation
intermediary compounds
intermediary
Prior art date
Application number
CL2012002082A
Other languages
English (en)
Inventor
Alberto Bologna
Patrizia Castoldi
Domenico Vergani
Giorgio Bertolini
Original Assignee
Euticals Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42174220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2012002082(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euticals Spa filed Critical Euticals Spa
Publication of CL2012002082A1 publication Critical patent/CL2012002082A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

Proceso para la preparación de lacosamida, por hidroximetilación; compuestos intermediarios.
CL2012002082A 2010-01-29 2012-07-26 Proceso para la preparacion de lacosamida, por hidroximetilación; compuestos intermediarios. CL2012002082A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2010A000127A IT1398044B1 (it) 2010-01-29 2010-01-29 Processo per la preparazione della lacosamide

Publications (1)

Publication Number Publication Date
CL2012002082A1 true CL2012002082A1 (es) 2013-07-26

Family

ID=42174220

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012002082A CL2012002082A1 (es) 2010-01-29 2012-07-26 Proceso para la preparacion de lacosamida, por hidroximetilación; compuestos intermediarios.

Country Status (12)

Country Link
US (1) US8796488B2 (es)
EP (1) EP2528892B1 (es)
JP (1) JP5779592B2 (es)
KR (1) KR101766506B1 (es)
CN (1) CN102822140B (es)
BR (1) BR112012018625A2 (es)
CL (1) CL2012002082A1 (es)
ES (1) ES2495815T3 (es)
IL (1) IL220936A (es)
IT (1) IT1398044B1 (es)
RU (1) RU2585762C2 (es)
WO (1) WO2011092559A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9133101B2 (en) 2011-08-29 2015-09-15 Signa S.A. De C.V. Processes for the preparation of (R)-2-acetamido-N-benzyl-3-methoxypropionamide and intermediates thereof
CN102424655B (zh) * 2011-10-28 2014-04-16 杭州迪克化工技术有限公司 一种r-(-)-2-乙酰胺基-3-甲氧基-n-苄基丙酰胺的制备方法
CN102516114B (zh) * 2011-10-28 2014-04-16 杭州迪克化工技术有限公司 一种r-(-)-2-氨基-3-甲氧基-n-苄基丙酰胺-d-酒石酸盐及其制备方法
GB201219627D0 (en) 2012-11-01 2012-12-12 Cambrex Karlskoga Ab New process
WO2016021711A1 (ja) * 2014-08-07 2016-02-11 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
JPWO2016039393A1 (ja) * 2014-09-10 2017-06-22 株式会社エーピーアイ コーポレーション アミノ酸誘導体の製造方法
CN106699595B (zh) * 2015-07-21 2019-04-12 上海医药集团股份有限公司 一种拉科酰胺制备方法
CN106699605B (zh) * 2015-07-21 2019-08-20 上海医药集团股份有限公司 一种拉科酰胺中间体的甲基化方法
IN2015CH05001A (es) * 2015-09-18 2015-10-16 Divis Lab Ltd
WO2017082396A1 (ja) 2015-11-13 2017-05-18 株式会社エーピーアイ コーポレーション ラコサミド及びその中間体の製造方法
CN107641087A (zh) * 2017-06-01 2018-01-30 合肥远志医药科技开发有限公司 一种工业化拉科酰胺的制备方法
CN112574058B (zh) * 2020-12-31 2023-04-28 珠海润都制药股份有限公司 一种拉考沙胺的合成路线

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5773475A (en) * 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
ATE202079T1 (de) * 1996-03-15 2001-06-15 Res Corp Technologies Inc Krampflösende, enantiomere aminosäure-derivate
EP1642889A1 (en) 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
CN100584821C (zh) * 2007-07-31 2010-01-27 浙江九洲药业股份有限公司 一种制备光学纯度叔亮氨酸的方法
US8093426B2 (en) * 2007-12-04 2012-01-10 Ranbaxy Laboratories Limited Intermediate compounds and their use in preparation of lacosamide
CN101333175A (zh) * 2008-07-29 2008-12-31 东南大学 制备d-天冬酰胺及d-高丝氨酸的方法
WO2010052011A1 (en) * 2008-11-07 2010-05-14 Ucb Pharma, S.A. Novel process for the preparation of amino acid derivatives

Also Published As

Publication number Publication date
IL220936A (en) 2014-11-30
IT1398044B1 (it) 2013-02-07
EP2528892B1 (en) 2014-06-04
RU2585762C2 (ru) 2016-06-10
RU2012131215A (ru) 2014-03-10
US8796488B2 (en) 2014-08-05
US20130030216A1 (en) 2013-01-31
JP2013518092A (ja) 2013-05-20
JP5779592B2 (ja) 2015-09-16
KR101766506B1 (ko) 2017-08-08
IL220936A0 (en) 2012-09-24
ES2495815T3 (es) 2014-09-17
EP2528892A1 (en) 2012-12-05
CN102822140A (zh) 2012-12-12
KR20130006438A (ko) 2013-01-16
BR112012018625A2 (pt) 2016-04-05
ITMI20100127A1 (it) 2011-07-30
CN102822140B (zh) 2014-10-22
WO2011092559A1 (en) 2011-08-04

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