EA201490396A1 - Ингибиторы репликации вирусов гриппа - Google Patents

Ингибиторы репликации вирусов гриппа

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Publication number
EA201490396A1
EA201490396A1 EA201490396A EA201490396A EA201490396A1 EA 201490396 A1 EA201490396 A1 EA 201490396A1 EA 201490396 A EA201490396 A EA 201490396A EA 201490396 A EA201490396 A EA 201490396A EA 201490396 A1 EA201490396 A1 EA 201490396A1
Authority
EA
Eurasian Patent Office
Prior art keywords
structural formula
pharmaceutically acceptable
patient
biological sample
acceptable salt
Prior art date
Application number
EA201490396A
Other languages
English (en)
Other versions
EA023423B1 (ru
Inventor
Пол С. Чарифсон
Майкл П. Кларк
Упул К. Бандарадже
Рэнди С. Бетил
Майкл Дж. Бойд
Иоана Дейвис
Хунбо Дэн
Джон П. Даффи
Люк Дж. Фармер
Хуай Гао
Вэньсинь Гу
Джозеф М. Кеннеди
Брайан Ледфорд
Марк В. Ледебур
Франсуа Мальте
Эмануэле Перола
Тяньшэн Ван
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490396(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Вертекс Фармасьютикалз Инкорпорейтед filed Critical Вертекс Фармасьютикалз Инкорпорейтед
Publication of EA201490396A1 publication Critical patent/EA201490396A1/ru
Publication of EA023423B1 publication Critical patent/EA023423B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Способы ингибирования репликации вируса гриппа в биологическом образце или у пациента, уменьшения количества вируса гриппа в биологическом образце или у пациента и лечения гриппа у пациента включают введение в указанный биологический образец или пациенту эффективного количества соединения, соответствующего структурной формуле (I)или его фармацевтически приемлемой соли, где переменные структурной формулы (I) являются такими, как описано в настоящем описании. Соединение соответствует структурной формуле (I) или структурной формуле его фармацевтически приемлемой соли, где переменные структурной формулы (I) являются такими, как описано в настоящем описании. Фармацевтическая композиция содержит эффективное количество такого соединения или его фармацевтически приемлемой соли и фармацевтически приемлемый носитель, адъювант или наполнитель.
EA201490396A 2011-08-01 2012-08-01 Ингибиторы репликации вирусов гриппа EA023423B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161513793P 2011-08-01 2011-08-01
PCT/US2012/049097 WO2013019828A1 (en) 2011-08-01 2012-08-01 Inhibitors of influenza viruses replication

Publications (2)

Publication Number Publication Date
EA201490396A1 true EA201490396A1 (ru) 2014-06-30
EA023423B1 EA023423B1 (ru) 2016-06-30

Family

ID=46650922

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201692506A EA037372B1 (ru) 2011-08-01 2012-08-01 Ингибиторы репликации вирусов гриппа
EA201500265A EA027210B1 (ru) 2011-08-01 2012-08-01 Ингибиторы репликации вирусов гриппа
EA201490396A EA023423B1 (ru) 2011-08-01 2012-08-01 Ингибиторы репликации вирусов гриппа

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EA201692506A EA037372B1 (ru) 2011-08-01 2012-08-01 Ингибиторы репликации вирусов гриппа
EA201500265A EA027210B1 (ru) 2011-08-01 2012-08-01 Ингибиторы репликации вирусов гриппа

Country Status (36)

Country Link
US (5) US9051319B2 (ru)
EP (2) EP3147284B1 (ru)
JP (3) JP5917692B2 (ru)
KR (1) KR101967172B1 (ru)
CN (3) CN103764654B (ru)
AP (1) AP3867A (ru)
AR (1) AR087418A1 (ru)
AU (2) AU2012290127B2 (ru)
CA (1) CA2844054C (ru)
CL (1) CL2014000245A1 (ru)
CO (1) CO6940412A2 (ru)
CY (1) CY1118726T1 (ru)
DK (1) DK2739623T3 (ru)
EA (3) EA037372B1 (ru)
EC (1) ECSP14013189A (ru)
ES (2) ES2618919T3 (ru)
GE (2) GEP201606531B (ru)
HK (3) HK1194736A1 (ru)
HR (1) HRP20170421T1 (ru)
HU (1) HUE033752T2 (ru)
IL (2) IL230618A (ru)
IN (1) IN2014CN00562A (ru)
LT (1) LT2739623T (ru)
ME (1) ME02638B (ru)
MX (1) MX339149B (ru)
PE (1) PE20141209A1 (ru)
PL (1) PL2739623T3 (ru)
PT (1) PT2739623T (ru)
RS (1) RS55858B1 (ru)
SG (2) SG10201503835TA (ru)
SI (1) SI2739623T1 (ru)
TW (3) TWI619715B (ru)
UA (2) UA118010C2 (ru)
UY (1) UY34234A (ru)
WO (1) WO2013019828A1 (ru)
ZA (2) ZA201400604B (ru)

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