MX2017002972A - Pirrolopirimidinas para usarse en la infeccion por el virus de la gripe. - Google Patents

Pirrolopirimidinas para usarse en la infeccion por el virus de la gripe.

Info

Publication number
MX2017002972A
MX2017002972A MX2017002972A MX2017002972A MX2017002972A MX 2017002972 A MX2017002972 A MX 2017002972A MX 2017002972 A MX2017002972 A MX 2017002972A MX 2017002972 A MX2017002972 A MX 2017002972A MX 2017002972 A MX2017002972 A MX 2017002972A
Authority
MX
Mexico
Prior art keywords
pyrrolopyrimidines
influenza virus
virus infection
compounds
formula
Prior art date
Application number
MX2017002972A
Other languages
English (en)
Inventor
Werner Constant Johan Embrechts
Pierre Jean-Marie Bernard Raboisson
Gowan David Craig Mc
Tim Hugo Maria Jonckers
Jérôme Émile Georges Guillemont
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017002972A publication Critical patent/MX2017002972A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La invención se refiere a compuestos que tienen la estructura de fórmula (I) que se pueden utilizar para el tratamiento de infecciones de la gripe o contra estas. (ver Fórmula).
MX2017002972A 2014-09-08 2015-09-07 Pirrolopirimidinas para usarse en la infeccion por el virus de la gripe. MX2017002972A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14183984 2014-09-08
PCT/EP2015/070316 WO2016037953A1 (en) 2014-09-08 2015-09-07 Pyrrolopyrimidines for use in influenza virus infection

Publications (1)

Publication Number Publication Date
MX2017002972A true MX2017002972A (es) 2017-05-30

Family

ID=51535336

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002972A MX2017002972A (es) 2014-09-08 2015-09-07 Pirrolopirimidinas para usarse en la infeccion por el virus de la gripe.

Country Status (22)

Country Link
US (1) US9932346B2 (es)
EP (1) EP3191489B1 (es)
JP (1) JP6718451B2 (es)
KR (1) KR102531340B1 (es)
CN (1) CN106661036B (es)
AU (1) AU2015314394A1 (es)
BR (1) BR112017004524A2 (es)
CA (1) CA2957475A1 (es)
CL (1) CL2017000533A1 (es)
DK (1) DK3191489T3 (es)
EA (1) EA201790571A1 (es)
ES (1) ES2860688T3 (es)
HR (1) HRP20210038T1 (es)
HU (1) HUE053595T2 (es)
IL (1) IL250955A0 (es)
LT (1) LT3191489T (es)
MX (1) MX2017002972A (es)
PH (1) PH12017500393A1 (es)
SG (1) SG11201701621YA (es)
SI (1) SI3191489T1 (es)
WO (1) WO2016037953A1 (es)
ZA (1) ZA201701643B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
EP3294717B1 (en) 2015-05-13 2020-07-29 Vertex Pharmaceuticals Inc. Methods of preparing inhibitors of influenza viruses replication
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
CA3005921A1 (en) 2015-12-09 2017-06-15 Sunshine Lake Pharma Co., Ltd. Substituted-(pyrrolo[2,3-b]pyridin-3-yl)-pyrimidin derivatives and use thereof as inhibitors of influenza virus replication
AU2017205261B2 (en) 2016-01-07 2021-03-25 Janssen Sciences Ireland Uc Functionalized pentanoic acids for use in influenza viral infections
WO2017133665A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 6,7-diazaindazole and 6,7-diazaindole derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133669A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh 5, 7-diazaindole and 5, 7-diazaindazole derivatives and their use in the treatment, amelioration or prevention of influenza
CN107759571B (zh) 2016-08-16 2021-03-02 广东东阳光药业有限公司 流感病毒复制抑制剂及其使用方法和用途
CN106316886A (zh) * 2016-08-24 2017-01-11 泰州精英化成医药科技有限公司 顺式‑3‑（叔丁氧羰基氨基）环己烷甲酸的制备方法
US10647693B2 (en) 2016-08-30 2020-05-12 North & South Brother Pharmacy Investment Company Limited Inhibitors of influenza virus replication, application methods and uses thereof
AU2017376541B2 (en) 2016-12-15 2021-08-05 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
DK3557998T3 (da) 2016-12-23 2023-11-20 Aquinnah Pharmaceuticals Inc Sammensætninger, kompositioner og anvendelsesmetoder
CN108276401B (zh) 2017-01-05 2020-12-22 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
WO2018157830A1 (en) * 2017-03-02 2018-09-07 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
AU2018257778B2 (en) 2017-04-24 2022-02-17 Cocrystal Pharma, Inc. Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication
CN108727369B (zh) * 2017-04-25 2023-06-09 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006297351A1 (en) * 2005-09-30 2007-04-12 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
BR112013012502A2 (pt) * 2010-11-19 2019-03-06 Incyte Corporation pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak
KR20140014110A (ko) 2010-12-16 2014-02-05 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
RU2013132683A (ru) * 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
UA118010C2 (uk) * 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу

Also Published As

Publication number Publication date
AU2015314394A1 (en) 2017-03-02
CL2017000533A1 (es) 2017-10-06
ZA201701643B (en) 2018-12-19
IL250955A0 (en) 2017-04-30
LT3191489T (lt) 2021-01-25
PH12017500393A1 (en) 2017-07-17
JP2017527619A (ja) 2017-09-21
US9932346B2 (en) 2018-04-03
CN106661036A (zh) 2017-05-10
EP3191489A1 (en) 2017-07-19
KR102531340B1 (ko) 2023-05-10
US20170253600A1 (en) 2017-09-07
EP3191489B1 (en) 2021-01-06
ES2860688T3 (es) 2021-10-05
ES2860688T8 (es) 2022-01-18
SI3191489T1 (sl) 2021-02-26
JP6718451B2 (ja) 2020-07-08
HRP20210038T1 (hr) 2021-03-05
KR20170054420A (ko) 2017-05-17
HUE053595T2 (hu) 2021-07-28
BR112017004524A2 (pt) 2017-12-05
DK3191489T3 (da) 2021-03-29
SG11201701621YA (en) 2017-03-30
CA2957475A1 (en) 2016-03-17
EA201790571A1 (ru) 2017-08-31
CN106661036B (zh) 2022-03-15
WO2016037953A1 (en) 2016-03-17

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