MX2014001067A - Inhibidores de replicacion del virus de influenza. - Google Patents
Inhibidores de replicacion del virus de influenza.Info
- Publication number
- MX2014001067A MX2014001067A MX2014001067A MX2014001067A MX2014001067A MX 2014001067 A MX2014001067 A MX 2014001067A MX 2014001067 A MX2014001067 A MX 2014001067A MX 2014001067 A MX2014001067 A MX 2014001067A MX 2014001067 A MX2014001067 A MX 2014001067A
- Authority
- MX
- Mexico
- Prior art keywords
- patient
- influenza viruses
- pharmaceutically acceptable
- structural formula
- biological sample
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
Los métodos para inhibir la replicación de los virus de influenza en una muestra biológica o paciente, para reducir la cantidad de virus de influenza en una muestra biológica o paciente, y para tratar influenza en un paciente, comprenden administrar a la muestra biológica o paciente una cantidad efectiva de un compuesto representado por la Fórmula Estructural (I): o una de sus sales farmacéuticamente aceptables, en donde los valores de la Fórmula Estructural (I) se describen en la presente. Un compuesto está representado por la Fórmula Estructural (I) o una de sus sales farmacéuticamente aceptables, en donde los valores de la Fórmula Estructural (I) se describen en la presente. Una composición farmacéutica comprende una cantidad efectiva de tal compuesto o una de sus sales farmacéuticamente aceptables y un portador, adyuvante o vehículo farmacéuticamente aceptable.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161513793P | 2011-08-01 | 2011-08-01 | |
PCT/US2012/049097 WO2013019828A1 (en) | 2011-08-01 | 2012-08-01 | Inhibitors of influenza viruses replication |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014001067A true MX2014001067A (es) | 2014-03-27 |
MX339149B MX339149B (es) | 2016-05-13 |
Family
ID=46650922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014001067A MX339149B (es) | 2011-08-01 | 2012-08-01 | Inhibidores de replicacion del virus de influenza. |
Country Status (36)
Country | Link |
---|---|
US (5) | US9051319B2 (es) |
EP (2) | EP3147284B1 (es) |
JP (3) | JP5917692B2 (es) |
KR (1) | KR101967172B1 (es) |
CN (3) | CN103764654B (es) |
AP (1) | AP3867A (es) |
AR (1) | AR087418A1 (es) |
AU (2) | AU2012290127B2 (es) |
CA (1) | CA2844054C (es) |
CL (1) | CL2014000245A1 (es) |
CO (1) | CO6940412A2 (es) |
CY (1) | CY1118726T1 (es) |
DK (1) | DK2739623T3 (es) |
EA (3) | EA037372B1 (es) |
EC (1) | ECSP14013189A (es) |
ES (2) | ES2618919T3 (es) |
GE (2) | GEP201606531B (es) |
HK (3) | HK1194736A1 (es) |
HR (1) | HRP20170421T1 (es) |
HU (1) | HUE033752T2 (es) |
IL (2) | IL230618A (es) |
IN (1) | IN2014CN00562A (es) |
LT (1) | LT2739623T (es) |
ME (1) | ME02638B (es) |
MX (1) | MX339149B (es) |
PE (1) | PE20141209A1 (es) |
PL (1) | PL2739623T3 (es) |
PT (1) | PT2739623T (es) |
RS (1) | RS55858B1 (es) |
SG (2) | SG10201503835TA (es) |
SI (1) | SI2739623T1 (es) |
TW (3) | TWI619715B (es) |
UA (2) | UA118010C2 (es) |
UY (1) | UY34234A (es) |
WO (1) | WO2013019828A1 (es) |
ZA (2) | ZA201400604B (es) |
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US8921376B2 (en) * | 2005-05-20 | 2014-12-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
WO2009145814A2 (en) * | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
RS55341B1 (sr) | 2009-06-17 | 2017-03-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
RU2014103806A (ru) | 2011-07-05 | 2015-08-10 | Вертекс Фармасьютикалз Инкорпорейтед | Способы и промежуточные соединения для получения азаиндолов |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
NZ719729A (en) | 2013-11-13 | 2022-04-29 | Vertex Pharma | Inhibitors of influenza viruses replication |
DK3421468T3 (da) | 2013-11-13 | 2021-01-11 | Vertex Pharma | Fremgangsmåder til fremstilling af inhibitorer af re-plikation af influenzavira |
CN103922966B (zh) * | 2014-04-14 | 2015-10-21 | 武汉大学 | 作为甲型流感病毒抑制剂的甲酰胺和异腈类化合物及其制备与应用 |
AU2015298876B2 (en) * | 2014-08-08 | 2020-02-13 | Janssen Sciences Ireland Uc | Indoles for use in influenza virus infection |
MX2017002972A (es) * | 2014-09-08 | 2017-05-30 | Janssen Sciences Ireland Uc | Pirrolopirimidinas para usarse en la infeccion por el virus de la gripe. |
MA40773A (fr) | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus influenza a |
MA40772A (fr) * | 2014-10-02 | 2017-08-08 | Vertex Pharma | Variants du virus de la grippe a |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
EP3294735B8 (en) * | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
SI3380467T1 (sl) | 2015-11-27 | 2021-08-31 | Janssen Sciences Ireland Unlimited Company | Heterociklični indoli za uporabo v okužbi z virusom gripe |
KR20180088466A (ko) * | 2015-12-09 | 2018-08-03 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 인플루엔자 바이러스 복제 저해제, 활용 방법 및 그 용도 |
LT3400225T (lt) * | 2016-01-07 | 2021-12-10 | Janssen Sciences Ireland Unlimited Company | Pirolo-[2-3,b]pirimidin-piridinais pakeistos pentanoinės rūgštys gripo virusinės infekcijos gydymui |
LT3405466T (lt) | 2016-01-20 | 2021-01-25 | Janssen Sciences Ireland Unlimited Company | Arilu pakeistieji pirimidinai, skirti naudoti gripo viruso infekcijos atveju |
CN109790158B (zh) * | 2016-07-26 | 2022-06-24 | 苏州隆博泰药业有限公司 | 作为jak抑制剂杂环化合物,该化合物的盐类及其治疗用途 |
CN107759571B (zh) | 2016-08-16 | 2021-03-02 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其使用方法和用途 |
WO2018041091A1 (en) * | 2016-08-30 | 2018-03-08 | Sunshine Lake Pharma Co., Ltd. | Inhibitors of influenza virus replication, application methods and uses thereof |
CN106478460B (zh) * | 2016-09-28 | 2018-06-12 | 衢州学院 | 一种手性N-Boc-3-氨基-4-芳基-丁酸的合成方法 |
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CN109384783A (zh) * | 2017-08-09 | 2019-02-26 | 银杏树药业(苏州)有限公司 | 新型杂环化合物及其作为抗流感病毒抑制剂的医药用途 |
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CN112979647B (zh) * | 2021-03-12 | 2022-05-20 | 浙江大学 | 含氮杂氨基酸的氮杂吲哚衍生物及制备和应用 |
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- 2016-06-09 US US15/177,546 patent/US9908878B2/en active Active
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2017
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- 2017-03-15 CY CY20171100328T patent/CY1118726T1/el unknown
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2018
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2020
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