BRPI0714908B8 - derivados de pirimidina como inibidor de pi3k, composição farmacêutica e agente preventivo ou agente terapêutico de uma doença proliferativa que os compreende - Google Patents

derivados de pirimidina como inibidor de pi3k, composição farmacêutica e agente preventivo ou agente terapêutico de uma doença proliferativa que os compreende

Info

Publication number
BRPI0714908B8
BRPI0714908B8 BRPI0714908A BRPI0714908A BRPI0714908B8 BR PI0714908 B8 BRPI0714908 B8 BR PI0714908B8 BR PI0714908 A BRPI0714908 A BR PI0714908A BR PI0714908 A BRPI0714908 A BR PI0714908A BR PI0714908 B8 BRPI0714908 B8 BR PI0714908B8
Authority
BR
Brazil
Prior art keywords
pi3k inhibitor
pharmaceutical composition
proliferative disease
pyrimidine derivatives
agent
Prior art date
Application number
BRPI0714908A
Other languages
English (en)
Inventor
Kawada Hatsuo
Ebiike Hirosato
Ohwada Jun
Morikami Kenji
Koyama Kohei
Hasegawa Masami
Nakamura Mitsuaki
Yoshida Miyuki
Ishii Nobuya
Shimma Nobuo
Yamamoto Shun
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39032956&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0714908(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0714908A2 publication Critical patent/BRPI0714908A2/pt
Publication of BRPI0714908B1 publication Critical patent/BRPI0714908B1/pt
Publication of BRPI0714908B8 publication Critical patent/BRPI0714908B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

derivado de pirimidina como inibidor de pi3k e uso do mesmo. é fornecido um fármaco que é útil como preventivo ou terapêutico para câncer tendo como resultado efeitos inibidores de pi3k superiores, bem como estabilidade superior no corpo e solubilidade em água. um composto, ou sal farmaceuticamente aceitável deste, representado pela fórmula (i): (i) [em que, x representa, por exemplo, uma ligação simples; y representa, por exemplo, uma ligação simples (contanto que x e y não sejam simultaneamente ligações simples); z representa por exemplo, um átomo de hidrogênio etc.; m representa um número inteiro de 1 ou 2; e r1 representa um substituinte cíclico].
BRPI0714908A 2006-08-08 2007-08-07 derivados de pirimidina como inibidor de pi3k, composição farmacêutica e agente preventivo ou agente terapêutico de uma doença proliferativa que os compreende BRPI0714908B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2006216108 2006-08-08
JP2006-216108 2006-08-08
JP2007-118631 2007-04-27
JP2007118631 2007-04-27
PCT/JP2007/065396 WO2008018426A1 (fr) 2006-08-08 2007-08-07 Dérivé de pyrimidine comme inhibiteur de la PI3K et son utilisation

Publications (3)

Publication Number Publication Date
BRPI0714908A2 BRPI0714908A2 (pt) 2013-05-28
BRPI0714908B1 BRPI0714908B1 (pt) 2020-10-13
BRPI0714908B8 true BRPI0714908B8 (pt) 2021-05-25

Family

ID=39032956

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0714908A BRPI0714908B8 (pt) 2006-08-08 2007-08-07 derivados de pirimidina como inibidor de pi3k, composição farmacêutica e agente preventivo ou agente terapêutico de uma doença proliferativa que os compreende

Country Status (26)

Country Link
US (1) US8022205B2 (pt)
EP (1) EP2050749B1 (pt)
JP (1) JP4450857B2 (pt)
KR (1) KR101435692B1 (pt)
AR (1) AR062292A1 (pt)
AU (1) AU2007282535B9 (pt)
BR (1) BRPI0714908B8 (pt)
CA (1) CA2659604C (pt)
CL (1) CL2007002316A1 (pt)
CY (1) CY1119882T1 (pt)
DK (1) DK2050749T3 (pt)
ES (1) ES2657635T3 (pt)
HU (1) HUE035116T2 (pt)
IL (1) IL196601A (pt)
LT (1) LT2050749T (pt)
MX (1) MX2009001451A (pt)
MY (1) MY145385A (pt)
NO (1) NO342978B1 (pt)
NZ (1) NZ575274A (pt)
PE (1) PE20080527A1 (pt)
PL (1) PL2050749T3 (pt)
PT (1) PT2050749T (pt)
RU (1) RU2448109C2 (pt)
SI (1) SI2050749T1 (pt)
TW (1) TWI394758B (pt)
WO (1) WO2008018426A1 (pt)

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Also Published As

Publication number Publication date
AU2007282535A1 (en) 2008-02-14
US20100069629A1 (en) 2010-03-18
AR062292A1 (es) 2008-10-29
WO2008018426A1 (fr) 2008-02-14
JP4450857B2 (ja) 2010-04-14
AU2007282535B9 (en) 2013-06-20
EP2050749B1 (en) 2017-11-22
TWI394758B (zh) 2013-05-01
NZ575274A (en) 2010-11-26
RU2448109C2 (ru) 2012-04-20
SI2050749T1 (en) 2018-04-30
IL196601A (en) 2015-03-31
KR101435692B1 (ko) 2014-09-01
NO20084533L (no) 2009-01-09
JPWO2008018426A1 (ja) 2009-12-24
ES2657635T3 (es) 2018-03-06
MY145385A (en) 2012-01-31
CA2659604C (en) 2015-04-28
BRPI0714908A2 (pt) 2013-05-28
TW200817411A (en) 2008-04-16
IL196601A0 (en) 2009-11-18
EP2050749A1 (en) 2009-04-22
LT2050749T (lt) 2018-01-10
CA2659604A1 (en) 2008-02-14
HUE035116T2 (hu) 2018-05-02
KR20090047462A (ko) 2009-05-12
CL2007002316A1 (es) 2008-02-01
PE20080527A1 (es) 2008-07-09
BRPI0714908B1 (pt) 2020-10-13
EP2050749A4 (en) 2011-03-30
MX2009001451A (es) 2009-02-18
AU2007282535B2 (en) 2013-05-30
CY1119882T1 (el) 2018-06-27
NO342978B1 (no) 2018-09-17
DK2050749T3 (en) 2018-01-08
RU2009108328A (ru) 2010-09-20
PL2050749T3 (pl) 2018-03-30
US8022205B2 (en) 2011-09-20
PT2050749T (pt) 2018-01-02

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