IT201600092469A1 - Processo per la produzione di Blonanserina - Google Patents

Processo per la produzione di Blonanserina

Info

Publication number
IT201600092469A1
IT201600092469A1 IT102016000092469A IT201600092469A IT201600092469A1 IT 201600092469 A1 IT201600092469 A1 IT 201600092469A1 IT 102016000092469 A IT102016000092469 A IT 102016000092469A IT 201600092469 A IT201600092469 A IT 201600092469A IT 201600092469 A1 IT201600092469 A1 IT 201600092469A1
Authority
IT
Italy
Prior art keywords
blonanserine
production process
production
blonanserine production
Prior art date
Application number
IT102016000092469A
Other languages
English (en)
Inventor
Faveri Carla De
Florian Anton Martin Huber
Original Assignee
Lundbeck Pharmaceuticals Italy S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck Pharmaceuticals Italy S P A filed Critical Lundbeck Pharmaceuticals Italy S P A
Priority to IT102016000092469A priority Critical patent/IT201600092469A1/it
Priority to JP2017175716A priority patent/JP2018043989A/ja
Priority to KR1020170117353A priority patent/KR20180030390A/ko
Publication of IT201600092469A1 publication Critical patent/IT201600092469A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/02—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C255/03—Mononitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
IT102016000092469A 2016-09-14 2016-09-14 Processo per la produzione di Blonanserina IT201600092469A1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT102016000092469A IT201600092469A1 (it) 2016-09-14 2016-09-14 Processo per la produzione di Blonanserina
JP2017175716A JP2018043989A (ja) 2016-09-14 2017-09-13 ブロナンセリンを製造する方法
KR1020170117353A KR20180030390A (ko) 2016-09-14 2017-09-13 블로난세린 제조 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102016000092469A IT201600092469A1 (it) 2016-09-14 2016-09-14 Processo per la produzione di Blonanserina

Publications (1)

Publication Number Publication Date
IT201600092469A1 true IT201600092469A1 (it) 2018-03-14

Family

ID=57796868

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102016000092469A IT201600092469A1 (it) 2016-09-14 2016-09-14 Processo per la produzione di Blonanserina

Country Status (3)

Country Link
JP (1) JP2018043989A (it)
KR (1) KR20180030390A (it)
IT (1) IT201600092469A1 (it)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112110857A (zh) * 2019-06-20 2020-12-22 北京万全德众医药生物技术有限公司 一种布南色林的制备方法
CN111233707B (zh) * 2020-04-27 2020-08-18 南京远淑医药科技有限公司 一种4-氟苯甲酰基乙腈的合成及精制方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010056722A1 (en) * 2008-11-13 2010-05-20 Schering Corporation Gamma secretase modulators
KR20150117123A (ko) * 2014-04-09 2015-10-19 주식회사 삼오제약 블로난세린의 온화한 제조방법
CN105315206A (zh) * 2014-07-21 2016-02-10 高瑞耀业(北京)科技有限公司 制备高纯度布南色林的方法
WO2016076573A2 (ko) * 2014-11-11 2016-05-19 연성정밀화학(주) 블로난세린의 제조방법 및 그를 위한 중간체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2050749T (lt) * 2006-08-08 2018-01-10 Chugai Seiyaku Kabushiki Kaisha Pirimidino darinys, kaip pi3k inhibitorius, ir jo panaudojimas
US20090264648A1 (en) * 2008-01-14 2009-10-22 Wyeth Synthesis of pyrazoles
CN102093289B (zh) * 2010-10-29 2012-12-19 常州华生制药有限公司 布南色林中间体的制备方法
CN102030707A (zh) * 2010-11-12 2011-04-27 深圳万和制药有限公司 布南色林中间体的制备方法
JP2013216655A (ja) * 2012-04-09 2013-10-24 Mylan Laboratories Ltd ブロナンセリンの改善された調製方法
CN104507923B (zh) * 2012-08-02 2018-02-09 内尔维阿诺医学科学有限公司 作为激酶抑制剂的取代的吡咯类活性剂
GB201402277D0 (en) * 2014-02-10 2014-03-26 Sentinel Oncology Ltd Pharmaceutical compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010056722A1 (en) * 2008-11-13 2010-05-20 Schering Corporation Gamma secretase modulators
KR20150117123A (ko) * 2014-04-09 2015-10-19 주식회사 삼오제약 블로난세린의 온화한 제조방법
CN105315206A (zh) * 2014-07-21 2016-02-10 高瑞耀业(北京)科技有限公司 制备高纯度布南色林的方法
WO2016076573A2 (ko) * 2014-11-11 2016-05-19 연성정밀화학(주) 블로난세린의 제조방법 및 그를 위한 중간체

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
K. SUDARSHAN ET AL.: "An investigation into formation of impurities during synthesis of Blonanserin", ASIAN JOURNAL OF CHEMISTRY, vol. 26, no. 18, 1 September 2014 (2014-09-01), pages 5928 - 5930, XP002766652 *
OCHI T ET AL: "Syntheses and properties of the major hydroxy metabolites in humans of blonanserin AD-5423, a novel antipsychotic agent", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 15, no. 4, 15 February 2005 (2005-02-15), pages 1055 - 1059, XP027801852, ISSN: 0960-894X, [retrieved on 20050215] *

Also Published As

Publication number Publication date
JP2018043989A (ja) 2018-03-22
KR20180030390A (ko) 2018-03-22

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