BR112017025266A2 - processo para produzir brivaracetam - Google Patents
processo para produzir brivaracetamInfo
- Publication number
- BR112017025266A2 BR112017025266A2 BR112017025266A BR112017025266A BR112017025266A2 BR 112017025266 A2 BR112017025266 A2 BR 112017025266A2 BR 112017025266 A BR112017025266 A BR 112017025266A BR 112017025266 A BR112017025266 A BR 112017025266A BR 112017025266 A2 BR112017025266 A2 BR 112017025266A2
- Authority
- BR
- Brazil
- Prior art keywords
- brivaracetam
- produce
- produce brivaracetam
- Prior art date
Links
- MSYKRHVOOPPJKU-BDAKNGLRSA-N brivaracetam Chemical compound CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1 MSYKRHVOOPPJKU-BDAKNGLRSA-N 0.000 title 1
- 229960002161 brivaracetam Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/05—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/38—Acyl halides
- C07C53/46—Acyl halides containing halogen outside the carbonyl halide group
- C07C53/50—Acyl halides containing halogen outside the carbonyl halide group of acids containing three or more carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C71/00—Esters of oxyacids of halogens
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510271449.6A CN106279074B (zh) | 2015-05-25 | 2015-05-25 | 一种化合物及其制备方法和在合成布瓦西坦中的用途 |
| CN201510430387.9A CN106365986B (zh) | 2015-07-21 | 2015-07-21 | 化合物及其制备方法和在合成布瓦西坦中的用途 |
| CN201510648574.4A CN106432030B (zh) | 2015-10-10 | 2015-10-10 | 布瓦西坦的一种制备方法 |
| CN201610099672 | 2016-02-24 | ||
| PCT/US2016/033965 WO2016191435A1 (en) | 2015-05-25 | 2016-05-24 | Processes to produce brivaracetam |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017025266A2 true BR112017025266A2 (pt) | 2018-08-07 |
Family
ID=57394289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017025266A BR112017025266A2 (pt) | 2015-05-25 | 2016-05-24 | processo para produzir brivaracetam |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10221134B2 (pt) |
| EP (1) | EP3302441B1 (pt) |
| JP (1) | JP6872500B2 (pt) |
| KR (1) | KR102630456B1 (pt) |
| BR (1) | BR112017025266A2 (pt) |
| CA (1) | CA2984832A1 (pt) |
| ES (1) | ES2965746T3 (pt) |
| HR (1) | HRP20240027T1 (pt) |
| HU (1) | HUE064612T2 (pt) |
| IL (1) | IL255880B (pt) |
| MX (1) | MX2017015133A (pt) |
| PL (1) | PL3302441T3 (pt) |
| WO (1) | WO2016191435A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2984832A1 (en) * | 2015-05-25 | 2016-12-01 | Esteve Quimica S.A. | Processes to produce brivaracetam |
| CN107056643A (zh) * | 2017-03-01 | 2017-08-18 | 苏州鹏旭医药科技有限公司 | 一种化合物的晶型a及其制备纯化方法 |
| WO2018141276A1 (zh) * | 2017-02-05 | 2018-08-09 | 苏州鹏旭医药科技有限公司 | 布瓦西坦中间体的晶型a及其制备方法和布瓦西坦的晶型c及其制备方法 |
| CN108503573B (zh) * | 2017-02-24 | 2019-11-22 | 北京艾百诺医药股份有限公司 | 一种布瓦西坦的新的制备方法 |
| CN108503609B (zh) * | 2017-02-24 | 2019-12-24 | 北京艾百诺医药股份有限公司 | 一种制备光学纯的(r)-4-正丙基-二氢呋喃-2(3h)-酮的方法 |
| CN108689903B (zh) * | 2017-04-06 | 2019-12-24 | 北京艾百诺医药股份有限公司 | 一种布瓦西坦的新的制备方法 |
| WO2018220646A1 (en) * | 2017-05-29 | 2018-12-06 | Msn Laboratories Private Limited, R&D Center | An improved process for the preparation of (2s)-2-[(4r)-2-oxo-4-propyltetrahydro-1h-pyrrol-1-yl] butanamide and its intermediates thereof |
| WO2019087172A1 (en) * | 2017-12-19 | 2019-05-09 | Glenmark Pharmaceuticals Limited | Process for preparation of brivaracetam |
| CN108409557A (zh) * | 2018-05-17 | 2018-08-17 | 丽珠集团新北江制药股份有限公司 | 布瓦西坦新中间体及其合成方法和应用 |
| IT201800006320A1 (it) * | 2018-06-14 | 2019-12-14 | Processo per la sintesi asimmetrica di (r)-4-propildiidrofuran-2(3h)-one | |
| CN110615744B (zh) | 2018-06-20 | 2023-01-06 | 上海朴颐化学科技有限公司 | 一种布瓦西坦中间体及其制备方法 |
| AU2019291703B2 (en) | 2018-06-22 | 2021-09-23 | Fujian Haixi Pharmaceuticals Co., Ltd | Compound and use thereof in synthesis of brivaracetam intermediate and crude drug |
| WO2020148787A1 (en) * | 2019-01-17 | 2020-07-23 | Clininvent Research Pvt. Ltd. | Enantioselective synthesis of brivaracetam and intermediates thereof |
| CN112110843A (zh) * | 2019-06-20 | 2020-12-22 | 北京万全德众医药生物技术有限公司 | 一种布瓦西坦的新制备方法 |
| WO2021124066A1 (en) * | 2019-12-20 | 2021-06-24 | Glenmark Life Sciences Limited | Process for the preparation of brivaracetam |
| WO2021260721A1 (en) * | 2020-06-23 | 2021-12-30 | Clininvent Research Pvt. Ltd. | A new cost effective and scalable process for synthesizing pure brivaracetam |
| US11400074B1 (en) * | 2021-02-01 | 2022-08-02 | Divi's Laboratories Ltd. | Enzymatic process for the preparation of (2S)-2-[(4R)-2-oxo-4-propyl-pyrrolidin-1-yl]butyric acid and its conversion into brivaracetam |
| EP4387955A1 (en) * | 2021-08-16 | 2024-06-26 | Optimus Drugs Private Limited | Synthesis of brivaracetam |
| CN114634437B (zh) * | 2022-03-29 | 2023-05-30 | 武汉氟本氘合新材料科技有限公司 | 一种布瓦西坦的简易制备方法 |
| CN114989061A (zh) * | 2022-08-03 | 2022-09-02 | 江苏同禾药业有限公司 | 一种布瓦西坦的制备方法 |
| CN115466233A (zh) * | 2022-09-28 | 2022-12-13 | 合肥立方制药股份有限公司 | 一种布瓦西坦中间体（r）-4-丙基-二氢呋喃-2-酮的合成方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| EP1419144B1 (en) * | 2001-08-10 | 2008-10-08 | UCB Pharma S.A. | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
| EA010306B1 (ru) | 2003-09-24 | 2008-08-29 | Юсб, С.А. | Способ получения производных 2-оксо-1-пирролидина |
| TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| NZ566240A (en) | 2005-09-15 | 2011-05-27 | Ucb Pharma Sa | 4-substituted pyrrolidin-2-ones and their use |
| CA2632453A1 (en) | 2005-12-07 | 2007-06-14 | Ucb Pharma, S.A. | 3-carboxy- 2-oxo-1 -pyrrolidine derivatives and their uses |
| US8338621B2 (en) * | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
| KR20070081959A (ko) | 2006-02-14 | 2007-08-20 | (주)지앤테크 | 은이 포함된 정수기용 필터 |
| KR100846419B1 (ko) | 2007-08-10 | 2008-07-15 | 한국과학기술원 | 프레가발린의 신규한 제조 방법 |
| KR100915671B1 (ko) * | 2007-08-14 | 2009-09-04 | 한국과학기술원 | 치환된 γ-부티로락톤의 광학선택적 제조방법 |
| US20120021469A1 (en) * | 2009-03-27 | 2012-01-26 | Codexis, Inc. | Amidases and methods of their use |
| AU2011255281A1 (en) | 2010-05-21 | 2013-01-10 | Sloan-Kettering Institute For Cancer Research | Selective HDAC inhibitors |
| EP2696864A1 (en) | 2011-04-11 | 2014-02-19 | Akthelia Pharmaceuticals | Therapeutic compounds |
| US20140228579A1 (en) | 2013-02-14 | 2014-08-14 | Brock Unviersity | Method for the catalytic reduction of acid chlorides and imidoyl chlorides |
| CN103819389A (zh) * | 2014-02-17 | 2014-05-28 | 北京博泽德润医药科技开发有限公司 | 一种左乙拉西坦制备方法 |
| CA2984832A1 (en) | 2015-05-25 | 2016-12-01 | Esteve Quimica S.A. | Processes to produce brivaracetam |
| PL3371150T3 (pl) | 2015-11-03 | 2022-01-17 | UCB Biopharma SRL | Sposób wytwarzania briwaracetamu |
| WO2018220646A1 (en) | 2017-05-29 | 2018-12-06 | Msn Laboratories Private Limited, R&D Center | An improved process for the preparation of (2s)-2-[(4r)-2-oxo-4-propyltetrahydro-1h-pyrrol-1-yl] butanamide and its intermediates thereof |
| WO2019087172A1 (en) | 2017-12-19 | 2019-05-09 | Glenmark Pharmaceuticals Limited | Process for preparation of brivaracetam |
| WO2020148731A1 (en) | 2019-01-19 | 2020-07-23 | Stereokem Pvt. Ltd. | Process for preparation of brivaracetam intermediates and use thereof |
-
2016
- 2016-05-24 CA CA2984832A patent/CA2984832A1/en active Pending
- 2016-05-24 WO PCT/US2016/033965 patent/WO2016191435A1/en active Application Filing
- 2016-05-24 ES ES16800643T patent/ES2965746T3/es active Active
- 2016-05-24 KR KR1020177037062A patent/KR102630456B1/ko active IP Right Grant
- 2016-05-24 BR BR112017025266A patent/BR112017025266A2/pt not_active Application Discontinuation
- 2016-05-24 PL PL16800643.5T patent/PL3302441T3/pl unknown
- 2016-05-24 EP EP16800643.5A patent/EP3302441B1/en active Active
- 2016-05-24 HU HUE16800643A patent/HUE064612T2/hu unknown
- 2016-05-24 US US15/575,373 patent/US10221134B2/en active Active
- 2016-05-24 MX MX2017015133A patent/MX2017015133A/es unknown
- 2016-05-24 HR HRP20240027TT patent/HRP20240027T1/hr unknown
- 2016-05-24 JP JP2017561732A patent/JP6872500B2/ja active Active
-
2017
- 2017-11-23 IL IL255880A patent/IL255880B/en active IP Right Grant
-
2019
- 2019-01-24 US US16/256,596 patent/US11673862B2/en active Active
- 2019-01-24 US US16/256,522 patent/US20240199541A9/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| HUE064612T2 (hu) | 2024-04-28 |
| KR102630456B1 (ko) | 2024-01-29 |
| EP3302441C0 (en) | 2023-12-13 |
| HRP20240027T1 (hr) | 2024-04-26 |
| US20240199541A9 (en) | 2024-06-20 |
| US20180155284A1 (en) | 2018-06-07 |
| US20190152909A1 (en) | 2019-05-23 |
| US11673862B2 (en) | 2023-06-13 |
| US10221134B2 (en) | 2019-03-05 |
| US20190152908A1 (en) | 2019-05-23 |
| MX2017015133A (es) | 2018-08-01 |
| PL3302441T3 (pl) | 2024-05-20 |
| EP3302441B1 (en) | 2023-12-13 |
| WO2016191435A1 (en) | 2016-12-01 |
| CA2984832A1 (en) | 2016-12-01 |
| KR20180012788A (ko) | 2018-02-06 |
| JP2018523633A (ja) | 2018-08-23 |
| ES2965746T3 (es) | 2024-04-16 |
| IL255880A (en) | 2018-01-31 |
| JP6872500B2 (ja) | 2021-05-19 |
| EP3302441A4 (en) | 2019-01-09 |
| EP3302441A1 (en) | 2018-04-11 |
| IL255880B (en) | 2021-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
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Owner name: SUZHOU PENGXU PHARMATECH CO., LTD. (CN) |