PL2050749T3 - Pochodna pirymidyny jako inhibitor pi3k i jej zastosowanie - Google Patents
Pochodna pirymidyny jako inhibitor pi3k i jej zastosowanieInfo
- Publication number
- PL2050749T3 PL2050749T3 PL07792065T PL07792065T PL2050749T3 PL 2050749 T3 PL2050749 T3 PL 2050749T3 PL 07792065 T PL07792065 T PL 07792065T PL 07792065 T PL07792065 T PL 07792065T PL 2050749 T3 PL2050749 T3 PL 2050749T3
- Authority
- PL
- Poland
- Prior art keywords
- pi3k inhibitor
- pyrimidine derivative
- pyrimidine
- derivative
- pi3k
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006216108 | 2006-08-08 | ||
JP2007118631 | 2007-04-27 | ||
PCT/JP2007/065396 WO2008018426A1 (fr) | 2006-08-08 | 2007-08-07 | Dérivé de pyrimidine comme inhibiteur de la PI3K et son utilisation |
EP07792065.0A EP2050749B1 (en) | 2006-08-08 | 2007-08-07 | Pyrimidine derivative as pi3k inhibitor and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2050749T3 true PL2050749T3 (pl) | 2018-03-30 |
Family
ID=39032956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL07792065T PL2050749T3 (pl) | 2006-08-08 | 2007-08-07 | Pochodna pirymidyny jako inhibitor pi3k i jej zastosowanie |
Country Status (26)
Country | Link |
---|---|
US (1) | US8022205B2 (pl) |
EP (1) | EP2050749B1 (pl) |
JP (1) | JP4450857B2 (pl) |
KR (1) | KR101435692B1 (pl) |
AR (1) | AR062292A1 (pl) |
AU (1) | AU2007282535B9 (pl) |
BR (1) | BRPI0714908B8 (pl) |
CA (1) | CA2659604C (pl) |
CL (1) | CL2007002316A1 (pl) |
CY (1) | CY1119882T1 (pl) |
DK (1) | DK2050749T3 (pl) |
ES (1) | ES2657635T3 (pl) |
HU (1) | HUE035116T2 (pl) |
IL (1) | IL196601A (pl) |
LT (1) | LT2050749T (pl) |
MX (1) | MX2009001451A (pl) |
MY (1) | MY145385A (pl) |
NO (1) | NO342978B1 (pl) |
NZ (1) | NZ575274A (pl) |
PE (1) | PE20080527A1 (pl) |
PL (1) | PL2050749T3 (pl) |
PT (1) | PT2050749T (pl) |
RU (1) | RU2448109C2 (pl) |
SI (1) | SI2050749T1 (pl) |
TW (1) | TWI394758B (pl) |
WO (1) | WO2008018426A1 (pl) |
Families Citing this family (65)
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KR101512284B1 (ko) * | 2006-12-21 | 2015-04-15 | 네르비아노 메디칼 사이언시스 에스.알.엘. | 치환된 피라졸로-퀴나졸린 유도체, 이의 제조방법, 및 키나제 억제제로서의 이의 용도 |
TW200938201A (en) * | 2008-02-07 | 2009-09-16 | Chugai Pharmaceutical Co Ltd | Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
DK3289876T3 (da) * | 2008-06-16 | 2022-10-10 | Univ Tennessee Res Found | Forbindelser til behandling af cancer |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
US8513221B2 (en) * | 2008-07-07 | 2013-08-20 | Xcovery Holding, LLC | PI3K isoform selective inhibitors |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
GB2465405A (en) * | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
ES2539478T3 (es) * | 2008-11-11 | 2015-07-01 | Xcovery Holding Company Llc | Inhibidores de PI3K/mTOR cinasa |
NZ593536A (en) * | 2008-12-19 | 2013-07-26 | Genentech Inc | Quinoline derivatives and methods of use |
US8461158B2 (en) | 2009-03-27 | 2013-06-11 | Pathway Therapeutics Inc. | Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy |
WO2010114494A1 (en) * | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | 8-substituted-2-morpholino purines for use as pi3k and/or mtor inhibitors in the treatment of proliferative disorders |
EP3141252B8 (en) | 2009-06-17 | 2019-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
NZ597050A (en) | 2009-06-29 | 2014-02-28 | Incyte Corp | Pyrimidinones as pi3k inhibitors |
TW201105662A (en) | 2009-07-07 | 2011-02-16 | Pathway Therapeutics Ltd | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy |
SG179085A1 (en) * | 2009-09-09 | 2012-04-27 | Avila Therapeutics Inc | Pi3 kinase inhibitors and uses thereof |
US8759359B2 (en) | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
CN104592205A (zh) | 2010-03-01 | 2015-05-06 | Gtx公司 | 用于治疗癌的化合物 |
KR20130113950A (ko) | 2010-05-19 | 2013-10-16 | 엑스커버리 홀딩 컴퍼니 엘엘씨 | Mtor 선택적 키나아제 억제제 |
AR084366A1 (es) | 2010-12-20 | 2013-05-08 | Incyte Corp | N-(1-(fenil sustituido)etil)-9h-purin-6-aminas como inhibidores de pi3k |
WO2012107465A1 (en) * | 2011-02-09 | 2012-08-16 | F. Hoffmann-La Roche Ag | Heterocyclic compounds as pi3 kinase inhibitors |
SG193982A1 (en) | 2011-03-28 | 2013-11-29 | Mei Pharma Inc | (alpha- substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5 -triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in treating proliferative diseases |
EP2729465A2 (en) * | 2011-07-05 | 2014-05-14 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for producing azaindoles |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
BR122019020716B1 (pt) | 2011-09-02 | 2021-02-17 | Incyte Holdings Corporation | heterociclilaminas como inibidores de pi3k e composição farmacêutica que as compreende |
US20130123255A1 (en) * | 2011-11-10 | 2013-05-16 | Chugai Seiyaku Kabushiki Kaisha | Combination of a pi3k inhibitor and a mek inhibitor |
WO2013083810A1 (en) | 2011-12-09 | 2013-06-13 | F. Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
RU2630975C2 (ru) | 2012-05-16 | 2017-09-15 | Новартис Аг | Режим дозирования pi-3 киназы |
CN103450204B (zh) * | 2012-05-31 | 2016-08-17 | 中国科学院上海药物研究所 | 吡咯[2,1-f][1,2,4]并三嗪类化合物,其制备方法及用途 |
RU2618423C2 (ru) * | 2012-07-02 | 2017-05-03 | Тайхо Фармасьютикал Ко., Лтд. | Усилитель противоопухолевого эффекта, содержащий имидазооксазиновое соединение |
WO2014022728A1 (en) | 2012-08-02 | 2014-02-06 | Endo Pharmaceuticals, Inc | Substituted 5 - (quinazolin - 2 - yl) pyrimidin- 2 -amine derivatives useful as pi3k/mtor inhibitors for the treatment of cancer |
EP2914260A1 (en) | 2012-10-31 | 2015-09-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
CN105102000B (zh) * | 2012-11-01 | 2021-10-22 | 无限药品公司 | 使用pi3激酶亚型调节剂的癌症疗法 |
CN103588792B (zh) | 2013-03-04 | 2016-03-23 | 中国科学院上海药物研究所 | 吡啶并嘧啶或嘧啶并嘧啶类化合物、其制备方法、药物组合物及其用途 |
US9242969B2 (en) * | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
RU2663999C2 (ru) * | 2013-10-16 | 2018-08-14 | Шанхай Инли Фармасьютикал Ко., Лтд | Конденсированное гетероциклическое соединение, способ его получения, его фармацевтическая композиция и применения |
EP3851437A3 (en) | 2013-11-13 | 2021-11-03 | Vertex Pharmaceuticals Incorporated | Methods of preparing 1h-pyrrolo[2,3-b]pyridine derivates |
ES2896404T3 (es) | 2014-04-04 | 2022-02-24 | Crown Bioscience Inc Taicang | Métodos para determinar la capacidad de respuesta a inhibidores de MEK/ERK |
WO2015155624A1 (en) * | 2014-04-10 | 2015-10-15 | Pfizer Inc. | Dihydropyrrolopyrimidine derivatives |
US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
US10323044B2 (en) | 2015-02-27 | 2019-06-18 | Taiho Pharmaceutical Co., Ltd. | Crystal of imidazo-oxazine, pharmaceutical composition containing said crystal, and method for producing said crystal |
MD3262046T2 (ro) | 2015-02-27 | 2021-03-31 | Incyte Corp | Săruri de inhibitori ai PI3K și procedee pentru prepararea lor |
US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
JP6616244B2 (ja) * | 2015-05-29 | 2019-12-04 | 北興化学工業株式会社 | 新規なヒドロキシフェニルボロン酸エステルとその製造方法、およびヒドロキシビフェニル化合物の製造法 |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
AU2017265383B2 (en) * | 2016-05-18 | 2022-07-28 | Torqur Ag | Treatment of neurological disorders |
CN109415369B (zh) | 2016-07-08 | 2021-12-07 | 豪夫迈·罗氏有限公司 | 稠合嘧啶衍生物 |
JP6980751B2 (ja) | 2016-07-14 | 2021-12-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 縮合ピリミジン誘導体 |
IT201600092469A1 (it) * | 2016-09-14 | 2018-03-14 | Lundbeck Pharmaceuticals Italy S P A | Processo per la produzione di Blonanserina |
JP6956175B2 (ja) | 2016-10-04 | 2021-11-02 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二環式ヘテロアリール誘導体 |
MX2019013862A (es) | 2017-05-23 | 2020-01-20 | Mei Pharma Inc | Terapia de combinacion. |
BR112020002984A2 (pt) | 2017-08-14 | 2020-08-11 | Mei Pharma, Inc. | terapia combinada |
EP3717472B1 (en) | 2017-11-27 | 2022-07-27 | F. Hoffmann-La Roche AG | Pyrimidine derivatives |
US20230271965A1 (en) * | 2020-06-03 | 2023-08-31 | Kineta, Inc. | Bicyclic heteroarenes and methods of their use |
TW202220661A (zh) | 2020-08-07 | 2022-06-01 | 德商柏林化學股份公司 | 包含pi3k抑制劑之經改良醫藥調配物 |
AU2022253683A1 (en) | 2021-04-09 | 2023-10-26 | Immunic Ag | Deuterated dhodh inhibitors |
WO2023107603A1 (en) * | 2021-12-08 | 2023-06-15 | Kineta, Inc. | Pyrimidines and methods of their use |
WO2023107623A2 (en) * | 2021-12-08 | 2023-06-15 | Kineta, Inc. | Bicyclic heteroarenes and methods of their use |
WO2024023766A1 (en) | 2022-07-28 | 2024-02-01 | Berlin-Chemie Ag | P13k inhibitor combination therapy |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08325268A (ja) * | 1986-02-24 | 1996-12-10 | Mitsui Petrochem Ind Ltd | ピロロ〔3,4−d〕ピリミジン誘導体 |
EP0799617A3 (en) | 1986-02-24 | 1997-11-12 | Mitsui Petrochemical Industries, Ltd. | Therapeutic agent for neurological diseases |
KR0155955B1 (ko) * | 1989-10-11 | 1998-11-16 | 이따가끼 히로시 | 2 환성 피리미딘 유도체, 그의 제조방법 및 그를 유효성분으로 하는 의약제제 |
TW530047B (en) * | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
ES2372028T3 (es) * | 2000-10-23 | 2012-01-13 | Glaxosmithkline Llc | Nuevo compuesto de 8h-pirido[2,3-d]pirimidin-7-ona trisustituida para el tratamiento de enfermedades mediadas por la csbp/p38 quinasa. |
WO2004043367A2 (en) * | 2002-11-06 | 2004-05-27 | Bristol-Myers Squibb Company | Fused heterocyclic compounds and use thereof |
CA2507100C (en) * | 2002-11-21 | 2012-10-09 | Chiron Corporation | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
RU2328497C2 (ru) * | 2003-05-05 | 2008-07-10 | Ф.Хоффманн-Ля Рош Аг | Конденсированные производные пиримидина и лекарственное средство, обладающее активностью в отношении crf |
-
2007
- 2007-08-07 US US12/376,039 patent/US8022205B2/en active Active
- 2007-08-07 MX MX2009001451A patent/MX2009001451A/es active IP Right Grant
- 2007-08-07 LT LTEP07792065.0T patent/LT2050749T/lt unknown
- 2007-08-07 RU RU2009108328/04A patent/RU2448109C2/ru active
- 2007-08-07 NZ NZ575274A patent/NZ575274A/en unknown
- 2007-08-07 ES ES07792065T patent/ES2657635T3/es active Active
- 2007-08-07 PT PT77920650T patent/PT2050749T/pt unknown
- 2007-08-07 PL PL07792065T patent/PL2050749T3/pl unknown
- 2007-08-07 MY MYPI20090459A patent/MY145385A/en unknown
- 2007-08-07 AU AU2007282535A patent/AU2007282535B9/en active Active
- 2007-08-07 CA CA2659604A patent/CA2659604C/en active Active
- 2007-08-07 BR BRPI0714908A patent/BRPI0714908B8/pt active IP Right Grant
- 2007-08-07 HU HUE07792065A patent/HUE035116T2/hu unknown
- 2007-08-07 SI SI200731994T patent/SI2050749T1/en unknown
- 2007-08-07 WO PCT/JP2007/065396 patent/WO2008018426A1/ja active Search and Examination
- 2007-08-07 JP JP2008528817A patent/JP4450857B2/ja active Active
- 2007-08-07 KR KR1020097002650A patent/KR101435692B1/ko active IP Right Grant
- 2007-08-07 EP EP07792065.0A patent/EP2050749B1/en active Active
- 2007-08-07 DK DK07792065.0T patent/DK2050749T3/en active
- 2007-08-08 PE PE2007001059A patent/PE20080527A1/es active IP Right Grant
- 2007-08-08 CL CL200702316A patent/CL2007002316A1/es unknown
- 2007-08-08 AR ARP070103510A patent/AR062292A1/es active IP Right Grant
- 2007-08-08 TW TW096129165A patent/TWI394758B/zh active
-
2008
- 2008-10-28 NO NO20084533A patent/NO342978B1/no unknown
-
2009
- 2009-01-20 IL IL196601A patent/IL196601A/en active IP Right Grant
-
2017
- 2017-12-28 CY CY20171101353T patent/CY1119882T1/el unknown
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