PE20110294A1 - Compuestos heterociclicos como inhibidores de enzimas de senal especifica - Google Patents

Compuestos heterociclicos como inhibidores de enzimas de senal especifica

Info

Publication number
PE20110294A1
PE20110294A1 PE2011000796A PE2011000796A PE20110294A1 PE 20110294 A1 PE20110294 A1 PE 20110294A1 PE 2011000796 A PE2011000796 A PE 2011000796A PE 2011000796 A PE2011000796 A PE 2011000796A PE 20110294 A1 PE20110294 A1 PE 20110294A1
Authority
PE
Peru
Prior art keywords
alkyl
inhibitors
optionally substituted
specific signal
heteroaryl
Prior art date
Application number
PE2011000796A
Other languages
English (en)
Inventor
Steffen Steurer
Peter Ettmayer
Andreas Mantoulidis
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40019293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110294(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE20110294A1 publication Critical patent/PE20110294A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS HETEROCICLICOS DE FORMULA (1) DONDE R1 ES UN HETEROARILO DE 5 A 6 MIEMBROS O UN HETEROARILO BICICLICO DE 9 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDOS CON Rb O Rc, EN DONDE Rb ES CN, NO2, N3, ENTRE OTROS; Rc ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C10), ENTRE OTROS; R2 ES ARILO(C6-C10) O HETEROARILO DE 5 A 12 MIEMBROS OPCIONALMENTE SUSTITUIDO CON Rb O Rc; R3 ES H, CN, NO2, ALQUILO(C1-C4), ENTRE OTROS; X1, X2 Y X3 SON CADA UNO N O CR4, EN DONDE R4 ES H, NH2, NH(ALQUILO C1-C4), ALCOXI(C1-C4), ENTRE OTROS; L1 ES (R2)-C(O)NH O (R2)-NHC(O); Q ES UN COMPUESTO DE FORMULA (i), (ii), (iii), ENTRE OTROS, OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6). SON COMPUESTOS PREFERIDOS: N-(5-TERC-BUTIL-ISOXAZOL-3-IL)-5-[4-(1,5-DIMETIL-1H-PIRAZOL-4-IL)-1,2,3-TRIAZOL-1-IL]-6-METIL-NICOTINAMIDA; 5-[4-(1,5-DIMETIL-1H-PIRAZOL-4-IL)-1,2,3-TRIAZOL-1-IL]-6-METIL-N-(4-TRIFLUOROMETIL-PIRIDIN-2-IL)-NICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE ENZIMAS DE SENALES ESPECIFICAS QUE PARTICIPAN EN EL CONTROL DE LA PROLIFERACION CELULAR SIENDO UTILES EN EL TRATAMIENTO DE SARCOMA, LEUCEMIA, TUMORES SOLIDOS, PSORIASIS.
PE2011000796A 2008-09-29 2009-09-28 Compuestos heterociclicos como inhibidores de enzimas de senal especifica PE20110294A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08165437 2008-09-29

Publications (1)

Publication Number Publication Date
PE20110294A1 true PE20110294A1 (es) 2011-05-26

Family

ID=40019293

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000796A PE20110294A1 (es) 2008-09-29 2009-09-28 Compuestos heterociclicos como inhibidores de enzimas de senal especifica

Country Status (20)

Country Link
US (1) US8778929B2 (es)
EP (1) EP2350052B1 (es)
JP (1) JP5603869B2 (es)
KR (1) KR20110063574A (es)
CN (1) CN102227421A (es)
AR (1) AR073700A1 (es)
AU (1) AU2009295855A1 (es)
BR (1) BRPI0920608A2 (es)
CA (1) CA2738448A1 (es)
CL (1) CL2011000691A1 (es)
CO (1) CO6351739A2 (es)
EA (1) EA201100564A1 (es)
EC (1) ECSP11010930A (es)
IL (1) IL211744A0 (es)
MA (1) MA32656B1 (es)
MX (1) MX2011003292A (es)
PE (1) PE20110294A1 (es)
TW (1) TW201018670A (es)
UY (1) UY32146A (es)
WO (1) WO2010034838A2 (es)

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Also Published As

Publication number Publication date
CN102227421A (zh) 2011-10-26
US20110312939A1 (en) 2011-12-22
IL211744A0 (en) 2011-06-30
UY32146A (es) 2010-04-30
US8778929B2 (en) 2014-07-15
BRPI0920608A2 (pt) 2019-09-24
KR20110063574A (ko) 2011-06-10
JP2012504114A (ja) 2012-02-16
WO2010034838A3 (en) 2010-11-18
AR073700A1 (es) 2010-11-24
CO6351739A2 (es) 2011-12-20
MX2011003292A (es) 2011-04-21
JP5603869B2 (ja) 2014-10-08
EP2350052A2 (en) 2011-08-03
CA2738448A1 (en) 2010-04-01
TW201018670A (en) 2010-05-16
ECSP11010930A (es) 2011-04-29
EP2350052B1 (en) 2014-08-13
MA32656B1 (fr) 2011-09-01
EA201100564A1 (ru) 2011-12-30
AU2009295855A1 (en) 2010-04-01
WO2010034838A2 (en) 2010-04-01
CL2011000691A1 (es) 2011-07-29

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