PE20070795A1 - Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa - Google Patents

Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa

Info

Publication number
PE20070795A1
PE20070795A1 PE2006001275A PE2006001275A PE20070795A1 PE 20070795 A1 PE20070795 A1 PE 20070795A1 PE 2006001275 A PE2006001275 A PE 2006001275A PE 2006001275 A PE2006001275 A PE 2006001275A PE 20070795 A1 PE20070795 A1 PE 20070795A1
Authority
PE
Peru
Prior art keywords
urea
kinase inhibitors
compounds
methyl
optionally substituted
Prior art date
Application number
PE2006001275A
Other languages
English (en)
Inventor
Jolie Anne Bastian
De Blas Jesus Andres Blas
Kevin John Hudziak
Tiechao Li
De Uralde Garmendia Beatriz Lopez
Mary Margaret Mader
Michael Ray Myers
Mark Andrew Pobanz
Chuan Shih
Boyu Zhong
Dios Alfonso De
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43298635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070795(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20070795A1 publication Critical patent/PE20070795A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), DONDE R1 ES ALQUILO(C1-C7) OPCIONALMENTE SUSTITUIDO CON HALO, ALQUILHALO(C1-C4), O CICLOALQUILO(C3-C6) OPCIONALMENTE SUSTITUIDO, O TRIMETILSILILO; R2 ES FENILO O PIRIDINILO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C4); Z ES UN GRUPO a) O b); X ES UN GRUPO i), ii) y iii). SON PREFERIDOS: 1-{6-[4-(2,2-DIMETIL-PENTANOIL)-PIPERAZIN-1-IL]-PIRIDIN-3-IL}-3-[5-(1-METIL-CICLOPROPIL)-2-p-TOLIL-2H-PIRAZOL-3-IL]-UREA, 1-{6-[4-(1-METIL-CICLOHEXANECARBONIL)-PIPERAZIN-1-IL]-PIRIDIN-3-IL}-3-[5-(1-METIL-CICLOPROPIL)-2-p-TOLIL-2H-PIRAZOL-3-IL]-UREA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE CINASA p38 Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS, CARDIOVASCULARES Y DEL SISTEMA NERVIOSO CENTRAL
PE2006001275A 2005-10-28 2006-10-20 Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa PE20070795A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73160405P 2005-10-28 2005-10-28
EP06380151 2006-06-02
US82196306P 2006-08-10 2006-08-10

Publications (1)

Publication Number Publication Date
PE20070795A1 true PE20070795A1 (es) 2007-08-24

Family

ID=43298635

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001275A PE20070795A1 (es) 2005-10-28 2006-10-20 Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa

Country Status (19)

Country Link
US (1) US7652015B2 (es)
EP (1) EP1943243B1 (es)
KR (1) KR101004156B1 (es)
AR (1) AR056582A1 (es)
AT (1) ATE493403T1 (es)
AU (1) AU2006309044B2 (es)
BR (1) BRPI0616901A2 (es)
CA (1) CA2627673A1 (es)
DK (1) DK1943243T3 (es)
DO (1) DOP2006000234A (es)
EA (1) EA015189B1 (es)
PE (1) PE20070795A1 (es)
PL (1) PL1943243T3 (es)
PT (1) PT1943243E (es)
RS (1) RS51949B (es)
SI (1) SI1943243T1 (es)
TN (1) TNSN08191A1 (es)
TW (1) TWI325423B (es)
WO (1) WO2007053394A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
JP5787977B2 (ja) 2010-04-08 2015-09-30 レスピバート・リミテツド Ｐ３８ｍａｐキナーゼ阻害剤
WO2011158044A2 (en) 2010-06-17 2011-12-22 Respivert Limited Respiratory formulations and compounds for use therein
CA2842976A1 (en) 2011-07-26 2013-01-31 Grunenthal Gmbh Substituted bicyclic aromatic carboxamide and urea derivatives as vanilloid receptor ligands
EP2890460B1 (en) 2012-08-29 2017-02-22 Respivert Limited Kinase inhibitors
WO2014033447A2 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
US9783556B2 (en) 2012-08-29 2017-10-10 Respivert Limited Kinase inhibitors
US9732063B2 (en) 2012-11-16 2017-08-15 Respivert Limited Kinase inhibitors
EP2981534B1 (en) 2013-04-02 2017-07-19 Topivert Pharma Limited Kinase inhibitors based upon n-alkyl pyrazoles
BR112015024671A2 (pt) 2013-04-02 2017-07-18 Respivert Ltd derivados de ureia úteis como inibidores de quinase
JP6514703B2 (ja) 2013-12-20 2019-05-15 トピバート ファーマ リミテッド キナーゼインヒビターとして有用な尿素誘導体
CN106257976B (zh) 2014-03-07 2021-02-02 拜奥克里斯特制药公司 人类血浆激肽释放酶抑制剂
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
EP3440073B1 (en) 2016-04-06 2022-06-08 Oxular Acquisitions Limited Kinase inhibitors
CN114732910A (zh) 2017-10-05 2022-07-12 弗尔康医疗公司 P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
KR20200095467A (ko) 2017-10-27 2020-08-10 베링거 인겔하임 인터내셔날 게엠베하 피리딘 카보닐 유도체 및 trpc6 억제제로서 이의 치료학적 용도

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69836563T2 (de) 1997-12-22 2007-05-16 Bayer Pharmaceuticals Corp., West Haven INHIBIERUNG DER p38 KINASE-AKTIVITÄT DURCH DIE VERWENDUNG VON ARYL- UND HETEROARYL-SUBSTITUIERTEN HARNSTOFFEN
ES2308523T3 (es) * 2004-06-23 2008-12-01 Eli Lilly And Company Inhibidores de quinasa.

Also Published As

Publication number Publication date
KR101004156B1 (ko) 2010-12-27
US20080269244A1 (en) 2008-10-30
US7652015B2 (en) 2010-01-26
AR056582A1 (es) 2007-10-10
TWI325423B (en) 2010-06-01
EP1943243B1 (en) 2010-12-29
EA200801199A1 (ru) 2008-08-29
RS51949B (en) 2012-02-29
PL1943243T3 (pl) 2011-05-31
EA015189B1 (ru) 2011-06-30
PT1943243E (pt) 2011-01-11
AU2006309044B2 (en) 2011-10-13
EP1943243A1 (en) 2008-07-16
TNSN08191A1 (en) 2009-10-30
BRPI0616901A2 (pt) 2011-07-05
KR20080053394A (ko) 2008-06-12
AU2006309044A1 (en) 2007-05-10
CA2627673A1 (en) 2007-05-10
TW200800184A (en) 2008-01-01
SI1943243T1 (sl) 2011-04-29
DOP2006000234A (es) 2007-05-31
WO2007053394A1 (en) 2007-05-10
ATE493403T1 (de) 2011-01-15
DK1943243T3 (da) 2011-03-07

Similar Documents

Publication Publication Date Title
PE20070795A1 (es) Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa
GB0402137D0 (en) Novel compounds
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
NO20071593L (no) Pyrimidinderivater
PE20130774A1 (es) Compuestos heterociclicos activadores de ampk y metodos para emplearlos
NO20080675L (no) P38-Map kinaseinhibitorer og metoder for deres anvendelse
NO20070731L (no) Heterocykliske forbindelser.
NO20084418L (no) Azolopyridin-3-on derivater som inhibitorer av endoteliallipase
NO20075273L (no) Nye forbindelser
MY148375A (en) Delta and epsilon crystal forms of imatinib mesylate
NO20063599L (no) Ytterligere heterosykliske forbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister
NO20081434L (no) 5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser
CY1111772T1 (el) Μονοϋδροχλωρικο μονοϋδρικο αλας 4-μεθυλο-ν-[3-(4-μεθυλ-ιμιδαζολ-1-υλο)-5-τριφλουορομεθυλο-φαινυλο]-3-(4-πυριδιν-3-υλο-πυριμιδιν-2-υλαμινο)-βενζαμιδιου
DE602005010821D1 (de) Kondensierte heteroyralderivate und deren verwendung als p38-kinase-inhibitoren
DE60315146D1 (de) Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase
NO20070532L (no) Substituerte 2-alkyl-kinazolinonderivater som PARP-inhibitorer
PE20090714A1 (es) Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido
ECSP055640A (es) Composiciones de pirazol útiles como inhibidores de gsk-3
EA200601391A1 (ru) Производные хинолина для применения в качестве микобактериальных ингибиторов
NO20081581L (no) Polymorfer av benzoatsalt av 2-[[6-[(3R)-3-amino-l-piperldinyl]-3,4-dihydro-3-metyl-2,4-diokso- 1(2H)-pyrlmidinylJmetyl)benzonitril, og fremgangsmater for anvendelse derav
IS2520B (is) Nikótínamíð afleiður nytsamlegar sem P38 hindrar
PE20070004A1 (es) Imidazoquinolinas como inhibidores de quinasa de lipido
EA200801291A1 (ru) Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
WO2009065919A3 (de) Organische verbindungen
RS54457B1 (en) CRYSTAL (R) - (E) -2- (4- (2- (5- (1- (3,5-Dichloropyridin-4-yl) ethoxy) -1H-indazol-3-yl) vinyl) -1H- PIRAZOL-1-IL) ETHANOL AND ITS USE AS FGFR INHIBITOR

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed