BR112015024671A2 - derivados de ureia úteis como inibidores de quinase - Google Patents

derivados de ureia úteis como inibidores de quinase

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Publication number
BR112015024671A2
BR112015024671A2 BR112015024671A BR112015024671A BR112015024671A2 BR 112015024671 A2 BR112015024671 A2 BR 112015024671A2 BR 112015024671 A BR112015024671 A BR 112015024671A BR 112015024671 A BR112015024671 A BR 112015024671A BR 112015024671 A2 BR112015024671 A2 BR 112015024671A2
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
derivatives useful
urea derivatives
compounds
members
Prior art date
Application number
BR112015024671A
Other languages
English (en)
Inventor
Rigby Aaron
Sambrook-Smith Colin
William Harbottle Gareth
Colin Thor Fyfe Matthew
Meghani Premji
Malcolm Thom Stephen
Matthew Baker Thomas
Hasimbegovic Vedran
Original Assignee
Respivert Ltd
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201305945A external-priority patent/GB201305945D0/en
Priority claimed from GBGB1322678.2A external-priority patent/GB201322678D0/en
Priority claimed from GB201402647A external-priority patent/GB201402647D0/en
Application filed by Respivert Ltd, Topivert Pharma Ltd filed Critical Respivert Ltd
Publication of BR112015024671A2 publication Critical patent/BR112015024671A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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Abstract

resumo patente de invenção: "derivados úteis como inibidores de quinase". a presente invenção refere-se a compostos de fórmula i, em que r1a a r1e, r2 a r5, l e x1 a x3 têm os significados dados na descrição, em que os compostos têm atividade anti-inflamatória (por exemplo, por inibição de um ou mais dentre os membros: da família das enzimas proteína quinase ativadas por mitógeno de p38; syk quinase; e membros da família src de tirosina quinases) e têm uso na terapia, incluindo nas combinações farmacêuticas, especialmente no tratamento de doenças inflamatórias, incluindo doenças inflamatórias do pulmão, olhos e intestinos.
BR112015024671A 2013-04-02 2014-04-01 derivados de ureia úteis como inibidores de quinase BR112015024671A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB201305945A GB201305945D0 (en) 2013-04-02 2013-04-02 New compounds
GBGB1322678.2A GB201322678D0 (en) 2013-12-20 2013-12-20 New compounds
GB201402647A GB201402647D0 (en) 2014-02-14 2014-02-14 New compounds
PCT/GB2014/051022 WO2014162126A1 (en) 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors

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BR112015024671A2 true BR112015024671A2 (pt) 2017-07-18

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Family Applications (2)

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BR112015024678-8A BR112015024678B1 (pt) 2013-04-02 2014-04-01 Composto inibidor da cinase, formulação farmacêutica que compreende o mesmo, seus usos, processo para sua preparação e intermediários
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