MA40774A - Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 - Google Patents
Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38Info
- Publication number
- MA40774A MA40774A MA040774A MA40774A MA40774A MA 40774 A MA40774 A MA 40774A MA 040774 A MA040774 A MA 040774A MA 40774 A MA40774 A MA 40774A MA 40774 A MA40774 A MA 40774A
- Authority
- MA
- Morocco
- Prior art keywords
- diaryleurea
- kinase
- inhibitors
- derivatives
- diaryleurea derivatives
- Prior art date
Links
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C07F9/59—Hydrogenated pyridine rings
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- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
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- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
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GBGB1510694.1A GB201510694D0 (en) | 2015-06-18 | 2015-06-18 | New compounds |
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MA040774A MA40774A (fr) | 2014-10-01 | 2015-09-30 | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
MA040775A MA40775A (fr) | 2014-10-01 | 2015-09-30 | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
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MA040775A MA40775A (fr) | 2014-10-01 | 2015-09-30 | Dérivé d'acide 4-(4-(4-phényluréido-naphtalén -1-yl) oxy-pyridin-2-yl) amino-benzoïque utilisé en tant qu'inhibiteur de la kinase p38 |
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US (6) | US9499486B2 (fr) |
EP (2) | EP3201180A1 (fr) |
JP (2) | JP6608918B2 (fr) |
KR (2) | KR20170057445A (fr) |
CN (2) | CN106999478A (fr) |
AU (2) | AU2015326543B2 (fr) |
BR (2) | BR112017005531A2 (fr) |
CA (1) | CA2961870A1 (fr) |
EA (2) | EA035478B1 (fr) |
MA (2) | MA40774A (fr) |
MX (2) | MX2017004128A (fr) |
WO (2) | WO2016051187A1 (fr) |
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UA105763C2 (uk) | 2007-12-19 | 2014-06-25 | Кансер Рісерч Текнолоджі Лімітед | 8-ЗАМІЩЕНІ ПІРИДО[2,3-b]ПІРАЗИНИ ТА ЇХ ЗАСТОСУВАННЯ |
EP2531502B1 (fr) | 2010-02-01 | 2014-04-02 | Cancer Research Technology Limited | 1-(5-tert-butyl-2-phényl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-méthyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phényl]-urée et composés associés, et leur utilisation dans des traitements |
MY167798A (en) | 2011-10-03 | 2018-09-26 | Respivert Ltd | 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors |
EP2578582A1 (fr) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napthtalèn-1-yl) urées comme inhibiteurs de la p38 MAP kinase |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
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WO2014033446A1 (fr) | 2012-08-29 | 2014-03-06 | Respivert Limited | Inhibiteurs de kinases |
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MA40774A (fr) * | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
BR112018067552A2 (pt) | 2016-04-06 | 2019-01-08 | Topivert Pharma Ltd | inibidores de cinase |
WO2019071144A1 (fr) | 2017-10-05 | 2019-04-11 | Fulcrum Therapeutics, Inc. | Utilisation d'inhibiteurs de p38 pour réduire l'expression de dux4 |
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MY167798A (en) | 2011-10-03 | 2018-09-26 | Respivert Ltd | 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors |
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GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
US20150225373A1 (en) | 2012-08-29 | 2015-08-13 | Respivert Limited | Kinase inhibitors |
US9783556B2 (en) | 2012-08-29 | 2017-10-10 | Respivert Limited | Kinase inhibitors |
GB201215357D0 (en) | 2012-08-29 | 2012-10-10 | Respivert Ltd | Compounds |
WO2014033446A1 (fr) | 2012-08-29 | 2014-03-06 | Respivert Limited | Inhibiteurs de kinases |
US9732063B2 (en) | 2012-11-16 | 2017-08-15 | Respivert Limited | Kinase inhibitors |
US20160016934A1 (en) | 2013-03-14 | 2016-01-21 | Respivert Limited | Kinase inhibitors |
TWI641592B (zh) * | 2013-04-02 | 2018-11-21 | 英商瑞斯比維特有限公司 | 激酶抑制劑 |
WO2014162121A1 (fr) | 2013-04-02 | 2014-10-09 | Topivert Pharma Limited | Inhibiteurs de kinase à base de n-alkyl pyrazoles |
JP6514703B2 (ja) * | 2013-12-20 | 2019-05-15 | トピバート ファーマ リミテッド | キナーゼインヒビターとして有用な尿素誘導体 |
PL3105222T3 (pl) | 2014-02-14 | 2018-09-28 | Respivert Limited | Aromatyczne związki heterocykliczne jako związki przeciwzapalne |
MA40774A (fr) | 2014-10-01 | 2017-08-08 | Respivert Ltd | Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38 |
US20170209445A1 (en) | 2014-10-01 | 2017-07-27 | Respivert Limited | Kinase inhibitors |
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- 2015-10-01 EP EP15782017.6A patent/EP3201179A1/fr not_active Withdrawn
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