BR112017006073A2 - derivado de ácido 4-(4-(4-fenilureído-naftalen-1-il)óxi-piridin-2-il)amino-benzoico como inibidor de quinase de p38 - Google Patents

derivado de ácido 4-(4-(4-fenilureído-naftalen-1-il)óxi-piridin-2-il)amino-benzoico como inibidor de quinase de p38

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Publication number
BR112017006073A2
BR112017006073A2 BR112017006073A BR112017006073A BR112017006073A2 BR 112017006073 A2 BR112017006073 A2 BR 112017006073A2 BR 112017006073 A BR112017006073 A BR 112017006073A BR 112017006073 A BR112017006073 A BR 112017006073A BR 112017006073 A2 BR112017006073 A2 BR 112017006073A2
Authority
BR
Brazil
Prior art keywords
phenylureido
naphthalen
pyridin
oxy
amino
Prior art date
Application number
BR112017006073A
Other languages
English (en)
Inventor
Colin Thor Fyfe Matthew
Original Assignee
Respivert Ltd
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1417344.7A external-priority patent/GB201417344D0/en
Priority claimed from GBGB1510694.1A external-priority patent/GB201510694D0/en
Application filed by Respivert Ltd, Topivert Pharma Ltd filed Critical Respivert Ltd
Publication of BR112017006073A2 publication Critical patent/BR112017006073A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

é fornecido um composto de fórmula i, cujo composto tem atividade anti-inflamatória (por exemplo, através da inibição de um ou mais membros da: família de enzimas de proteína quinase de p38 ativada por mitógeno; syk quinase; e membros da família src de tirosina quinases) e tem uso em terapia, incluindo em combinações farmacêuticas, especialmente no tratamento de doenças inflamatórias, incluindo doenças inflamatórias do pulmão, olhos e intestinos.
BR112017006073A 2014-10-01 2015-10-01 derivado de ácido 4-(4-(4-fenilureído-naftalen-1-il)óxi-piridin-2-il)amino-benzoico como inibidor de quinase de p38 BR112017006073A2 (pt)

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GBGB1417344.7A GB201417344D0 (en) 2014-10-01 2014-10-01 New compounds
GBGB1510694.1A GB201510694D0 (en) 2015-06-18 2015-06-18 New compounds
PCT/GB2015/052877 WO2016051188A1 (en) 2014-10-01 2015-10-01 4-(4-(4-phenylureido-naphthalen-1-yl)oxy-pyridin-2-yl)amino-benzoic acid derivative as p38 kinase inhibitor

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BR112017005531A BR112017005531A2 (pt) 2014-10-01 2015-10-01 derivados de diaril ureia como inibidores de quinase p38

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US10125100B2 (en) 2018-11-13
US9822076B2 (en) 2017-11-21
BR112017005531A2 (pt) 2017-12-05
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US10392346B2 (en) 2019-08-27
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