BR112015026721A2 - derivados de 3-(2-aminopirimidin-4-il)-5-(3-hidroxipropinil)-1h-pirrolo[2,3-c]piridina como inibidores de nik para o tratamento de câncer - Google Patents

derivados de 3-(2-aminopirimidin-4-il)-5-(3-hidroxipropinil)-1h-pirrolo[2,3-c]piridina como inibidores de nik para o tratamento de câncer

Info

Publication number
BR112015026721A2
BR112015026721A2 BR112015026721A BR112015026721A BR112015026721A2 BR 112015026721 A2 BR112015026721 A2 BR 112015026721A2 BR 112015026721 A BR112015026721 A BR 112015026721A BR 112015026721 A BR112015026721 A BR 112015026721A BR 112015026721 A2 BR112015026721 A2 BR 112015026721A2
Authority
BR
Brazil
Prior art keywords
hydroxypropinyl
aminopyrimidin
pyrrolo
compounds
pyridine derivatives
Prior art date
Application number
BR112015026721A
Other languages
English (en)
Other versions
BR112015026721B1 (pt
Inventor
Macleod Calum
Hynd George
Kulagowski Janusz
Gary Montana John
Tisselli Patrizia
Edward Mann Samuel
Price Stephen
Aaron Panchal Terry
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112015026721A2 publication Critical patent/BR112015026721A2/pt
Publication of BR112015026721B1 publication Critical patent/BR112015026721B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo patente de invenção: "derivados de 3-(2-aminopirimidin-4-il)-5-(3-hidroxipropinil)-1h-pirrolo[2,3-c]piridina como inibidores de nik para o tratamento de câncer". a presente invenção refere-se aos compostos de fórmula (i) que são inibidores da quinase indutora do nf-?b (nik - também conhecida como map3k14) úteis para o tratamento de doenças tais como o câncer, distúrbios inflamatórios, distúrbios metabólicos, e distúrbios autoimunes. a invenção também é dirigida para composições farmacêuticas compreendendo esses compostos, para processos para preparação desses compostos e composições, e para o uso desses compostos ou composições farmacêuticas para a prevenção ou tratamento de doenças tais como câncer, distúrbios inflamatórios, distúrbios metabólicos incluindo obesidade e diabetes, e distúrbios autoimunes.
BR112015026721-1A 2013-04-24 2014-04-24 Derivados de 3-(2-aminopirimidin-4-il)-5-(3-hidroxipropinil)-1h-pirrolo[2,3-c]piridina, seu uso como inibidores de nik para o tratamento de câncer e composição farmacêutica que os compreende BR112015026721B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13165167.1 2013-04-24
EP13165167 2013-04-24
EP13186116.3 2013-09-26
EP13186116 2013-09-26
PCT/EP2014/058361 WO2014174021A1 (en) 2013-04-24 2014-04-24 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1h-pyrrolo[2,3-c]pyridine derivatives as nik inhibitors for the treatment of cancer

Publications (2)

Publication Number Publication Date
BR112015026721A2 true BR112015026721A2 (pt) 2017-07-25
BR112015026721B1 BR112015026721B1 (pt) 2022-07-19

Family

ID=50543609

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015026721-1A BR112015026721B1 (pt) 2013-04-24 2014-04-24 Derivados de 3-(2-aminopirimidin-4-il)-5-(3-hidroxipropinil)-1h-pirrolo[2,3-c]piridina, seu uso como inibidores de nik para o tratamento de câncer e composição farmacêutica que os compreende

Country Status (15)

Country Link
US (1) US9643964B2 (pt)
EP (1) EP2989101B1 (pt)
JP (1) JP6389511B2 (pt)
KR (1) KR102336291B1 (pt)
CN (1) CN105143223B (pt)
AU (1) AU2014259477B2 (pt)
BR (1) BR112015026721B1 (pt)
CA (1) CA2907751C (pt)
EA (1) EA029219B1 (pt)
ES (1) ES2773138T3 (pt)
HK (1) HK1215430A1 (pt)
IL (1) IL242170B (pt)
MX (1) MX369159B (pt)
TW (1) TWI663166B (pt)
WO (1) WO2014174021A1 (pt)

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TW201512173A (zh) 2013-08-22 2015-04-01 Hoffmann La Roche 炔基醇及其使用方法
TWI627173B (zh) * 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
TWI704146B (zh) * 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
CN110526912B (zh) * 2014-06-19 2023-02-14 武田药品工业株式会社 用于激酶抑制的杂芳基化合物
ES2715104T3 (es) * 2014-10-23 2019-05-31 Janssen Pharmaceutica Nv Nuevos derivados de pirazolopirimidina como inhibidores de nik
CN107074881B (zh) * 2014-10-23 2019-07-30 詹森药业有限公司 作为nik抑制剂的新的噻吩并嘧啶衍生物
EP3209662B1 (en) * 2014-10-23 2019-01-09 Janssen Pharmaceutica N.V. New compounds as nik inhibitors
WO2016062791A1 (en) 2014-10-23 2016-04-28 Janssen Pharmaceutica Nv New pyrazole derivatives as nik inhibitors
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
KR20180094940A (ko) * 2015-12-02 2018-08-24 아스트레아 테라퓨틱스 엘엘씨 피페리디닐 노시셉틴 수용체 화합물
CA3012031C (en) 2016-01-22 2024-03-26 Janssen Pharmaceutica Nv 6-membered heteroaromatic substituted cyanoindoline derivatives as nik inhibitors
AU2017209935B2 (en) 2016-01-22 2021-04-01 Janssen Pharmaceutica Nv New substituted cyanoindoline derivatives as NIK inhibitors
WO2018002217A1 (en) 2016-06-30 2018-01-04 Janssen Pharmaceutica Nv Heteroaromatic derivatives as nik inhibitors
WO2018002219A1 (en) 2016-06-30 2018-01-04 Janssen Pharmaceutica Nv Cyanoindoline derivatives as nik inhibitors
CN109863142B (zh) * 2016-08-24 2022-06-10 豪夫迈·罗氏有限公司 2-氮杂双环[3.1.0]己烷-3-酮衍生物及使用方法
WO2018037059A1 (en) * 2016-08-24 2018-03-01 F. Hoffmann-La Roche Ag 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
EP3976597A1 (en) 2019-05-31 2022-04-06 Janssen Pharmaceutica NV Small molecule inhibitors of nf-kb inducing kinase
CN113816957B (zh) * 2021-10-29 2023-04-07 浙江工业大学 4-(7-氮杂吲哚)-2-氨基嘧啶类化合物及其应用

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AR056786A1 (es) 2005-11-10 2007-10-24 Smithkline Beecham Corp Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com
DE102008005493A1 (de) 2008-01-22 2009-07-23 Merck Patent Gmbh 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate
JP2011525915A (ja) * 2008-06-26 2011-09-29 アムジエン・インコーポレーテツド キナーゼ阻害薬としてのアルキニルアルコール類
JP2011526931A (ja) * 2008-07-03 2011-10-20 エグゼリクシス， インコーポレイテッド Ｃｄｋモジュレーター
WO2010042337A1 (en) * 2008-10-07 2010-04-15 Merck Sharp & Dohme Corp. Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity
CN101723936B (zh) 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
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TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
CN107074881B (zh) 2014-10-23 2019-07-30 詹森药业有限公司 作为nik抑制剂的新的噻吩并嘧啶衍生物
EP3209662B1 (en) 2014-10-23 2019-01-09 Janssen Pharmaceutica N.V. New compounds as nik inhibitors
ES2715104T3 (es) 2014-10-23 2019-05-31 Janssen Pharmaceutica Nv Nuevos derivados de pirazolopirimidina como inhibidores de nik
WO2016062791A1 (en) 2014-10-23 2016-04-28 Janssen Pharmaceutica Nv New pyrazole derivatives as nik inhibitors

Also Published As

Publication number Publication date
CN105143223A (zh) 2015-12-09
HK1215430A1 (zh) 2016-08-26
EA029219B1 (ru) 2018-02-28
TW201534605A (zh) 2015-09-16
WO2014174021A1 (en) 2014-10-30
JP6389511B2 (ja) 2018-09-12
EP2989101A1 (en) 2016-03-02
CA2907751C (en) 2021-04-20
MX369159B (es) 2019-10-30
ES2773138T3 (es) 2020-07-09
CA2907751A1 (en) 2014-10-30
MX2015014944A (es) 2016-03-07
AU2014259477B2 (en) 2018-05-24
JP2016517859A (ja) 2016-06-20
US20160075699A1 (en) 2016-03-17
BR112015026721B1 (pt) 2022-07-19
IL242170B (en) 2020-08-31
CN105143223B (zh) 2018-11-30
US9643964B2 (en) 2017-05-09
KR102336291B1 (ko) 2021-12-07
EA201592033A1 (ru) 2016-04-29
EP2989101B1 (en) 2019-11-27
AU2014259477A1 (en) 2015-10-01
TWI663166B (zh) 2019-06-21
KR20150144763A (ko) 2015-12-28

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
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