JP6389511B2 - 癌を治療するための、ｎｉｋ阻害剤としての３−（２−アミノピリミジン−４−イル）−５−（３−ヒドロキシプロピニル）−１ｈ−ピロロ［２，３−ｃ］ピリジン誘導体 - Google Patents

癌を治療するための、ｎｉｋ阻害剤としての３−（２−アミノピリミジン−４−イル）−５−（３−ヒドロキシプロピニル）−１ｈ−ピロロ［２，３−ｃ］ピリジン誘導体 Download PDF

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JP6389511B2
JP6389511B2 JP2016509468A JP2016509468A JP6389511B2 JP 6389511 B2 JP6389511 B2 JP 6389511B2 JP 2016509468 A JP2016509468 A JP 2016509468A JP 2016509468 A JP2016509468 A JP 2016509468A JP 6389511 B2 JP6389511 B2 JP 6389511B2
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alkyl
substituted
het
hydrogen atom
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JP2016517859A (ja
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ハインド，ジョージ
プライス，ステファン
クラゴスキー，ジャヌス
マクラウド，カラム
エドワード マン，サムエル
エドワード マン，サムエル
アーロン パンチャル，テリー
アーロン パンチャル，テリー
ティセリ，パトリジア
ガリー モンタナ，ジョン
ガリー モンタナ，ジョン
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ヤンセン ファーマシューティカ エヌ．ベー．
ヤンセン ファーマシューティカ エヌ．ベー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016509468A 2013-04-24 2014-04-24 癌を治療するための、ｎｉｋ阻害剤としての３−（２−アミノピリミジン−４−イル）−５−（３−ヒドロキシプロピニル）−１ｈ−ピロロ［２，３−ｃ］ピリジン誘導体 Active JP6389511B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP13165167.1 2013-04-24
EP13165167 2013-04-24
EP13186116 2013-09-26
EP13186116.3 2013-09-26
PCT/EP2014/058361 WO2014174021A1 (en) 2013-04-24 2014-04-24 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1h-pyrrolo[2,3-c]pyridine derivatives as nik inhibitors for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2016517859A JP2016517859A (ja) 2016-06-20
JP6389511B2 true JP6389511B2 (ja) 2018-09-12

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JP2016509468A Active JP6389511B2 (ja) 2013-04-24 2014-04-24 癌を治療するための、ｎｉｋ阻害剤としての３−（２−アミノピリミジン−４−イル）−５−（３−ヒドロキシプロピニル）−１ｈ−ピロロ［２，３−ｃ］ピリジン誘導体

Country Status (15)

Country Link
US (1) US9643964B2 (pt)
EP (1) EP2989101B1 (pt)
JP (1) JP6389511B2 (pt)
KR (1) KR102336291B1 (pt)
CN (1) CN105143223B (pt)
AU (1) AU2014259477B2 (pt)
BR (1) BR112015026721B1 (pt)
CA (1) CA2907751C (pt)
EA (1) EA029219B1 (pt)
ES (1) ES2773138T3 (pt)
HK (1) HK1215430A1 (pt)
IL (1) IL242170B (pt)
MX (1) MX369159B (pt)
TW (1) TWI663166B (pt)
WO (1) WO2014174021A1 (pt)

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EP3036230A1 (en) 2013-08-22 2016-06-29 F. Hoffmann-La Roche AG Alkynyl alcohols and methods of use
TWI627173B (zh) * 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
TWI704146B (zh) * 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
ES2715500T3 (es) * 2014-06-19 2019-06-04 Ariad Pharma Inc Compuestos de heteroarilo para la inhibición de la quinasa
CA2960567C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Thienopyrimidine derivatives as nik inhibitors
CA2960336C (en) * 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Compounds as nik inhibitors
KR102499862B1 (ko) 2014-10-23 2023-02-13 얀센 파마슈티카 엔.브이. Ｎｉｋ 억제제로서의 신규 피라졸 유도체
EP3209663B1 (en) * 2014-10-23 2018-12-12 Janssen Pharmaceutica N.V. New pyrazolopyrimidine derivatives as nik inhibitors
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
JP7011596B2 (ja) * 2015-12-02 2022-02-10 アストライア セラピューティクス， エルエルシー ピペリジニルノシセプチン受容体化合物
KR20180100441A (ko) 2016-01-22 2018-09-10 잔센파마슈티카엔.브이. Nik 억제제로서 신규 치환된 시아노인돌린 유도체
AU2017208555B2 (en) 2016-01-22 2021-03-18 Janssen Pharmaceutica Nv New 6-membered heteroaromatic substituted cyanoindoline derivatives as NIK inhibitors
JP6936815B2 (ja) 2016-06-30 2021-09-22 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｉｋ阻害剤としてのヘテロ芳香族誘導体
US20190119299A1 (en) * 2016-06-30 2019-04-25 Janssen Pharmaceutica Nv Cyanoindoline derivatives as nik inhibitors
EP3504192B1 (en) * 2016-08-24 2022-04-06 F. Hoffmann-La Roche AG 2-azabicyclo[3.1.0]hexan-3-one derivatives and methods of use
JP7140751B2 (ja) * 2016-08-24 2022-09-21 エフ．ホフマン－ラ ロシュ アーゲー ２－アザビシクロ［３．１．０］ヘキサン－３－オン誘導体及び使用方法
BR112021023796A2 (pt) 2019-05-31 2022-02-08 Janssen Pharmaceutica Nv Inibidores de moléculas pequenas de quinase indutora de nf-capab
CN113816957B (zh) * 2021-10-29 2023-04-07 浙江工业大学 4-(7-氮杂吲哚)-2-氨基嘧啶类化合物及其应用

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Publication number Priority date Publication date Assignee Title
AR056786A1 (es) 2005-11-10 2007-10-24 Smithkline Beecham Corp Compuesto de 1h- imidazo ( 4,5-c) piridin-2-ilo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion, su uso para preparar unmedicamento, uso de una combinacion que omprende al compuesto y al menos un agente antineoplasico para preparar un medicamento y dicha com
DE102008005493A1 (de) 2008-01-22 2009-07-23 Merck Patent Gmbh 4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate
CA2728767A1 (en) * 2008-06-26 2009-12-30 Amgen Inc. Alkynyl alcohols as kinase inhibitors
CN102143746A (zh) * 2008-07-03 2011-08-03 埃克塞利希斯股份有限公司 Cdk 调节剂
WO2010042337A1 (en) * 2008-10-07 2010-04-15 Merck Sharp & Dohme Corp. Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity
CN101723936B (zh) 2008-10-27 2014-01-15 上海睿星基因技术有限公司 激酶抑制剂及其在药学中的用途
CA2827161A1 (en) * 2011-03-16 2012-09-20 F. Hoffmann-La Roche Ag 6,5-heterocyclic propargylic alcohol compounds and uses therefor
TWI627173B (zh) 2013-09-26 2018-06-21 比利時商健生藥品公司 作為ＮＩＫ抑制劑的新穎３－（１Ｈ－吡唑－４－基）－１Ｈ－吡咯并［２，３－ｃ］吡啶衍生物
TWI704146B (zh) 2013-09-26 2020-09-11 比利時商健生藥品公司 用作ＮＩＫ抑制劑之新的1-(４-嘧啶基)-１Ｈ-吡唑並[３,２-ｃ]吡啶衍生物
KR102499862B1 (ko) 2014-10-23 2023-02-13 얀센 파마슈티카 엔.브이. Ｎｉｋ 억제제로서의 신규 피라졸 유도체
EP3209663B1 (en) 2014-10-23 2018-12-12 Janssen Pharmaceutica N.V. New pyrazolopyrimidine derivatives as nik inhibitors
CA2960567C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Thienopyrimidine derivatives as nik inhibitors
CA2960336C (en) 2014-10-23 2023-03-07 Janssen Pharmaceutica Nv Compounds as nik inhibitors

Also Published As

Publication number Publication date
HK1215430A1 (zh) 2016-08-26
US9643964B2 (en) 2017-05-09
US20160075699A1 (en) 2016-03-17
WO2014174021A1 (en) 2014-10-30
KR20150144763A (ko) 2015-12-28
EA029219B1 (ru) 2018-02-28
ES2773138T3 (es) 2020-07-09
TWI663166B (zh) 2019-06-21
TW201534605A (zh) 2015-09-16
MX369159B (es) 2019-10-30
CA2907751C (en) 2021-04-20
IL242170B (en) 2020-08-31
AU2014259477A1 (en) 2015-10-01
EP2989101B1 (en) 2019-11-27
JP2016517859A (ja) 2016-06-20
EA201592033A1 (ru) 2016-04-29
BR112015026721A2 (pt) 2017-07-25
AU2014259477B2 (en) 2018-05-24
CA2907751A1 (en) 2014-10-30
CN105143223A (zh) 2015-12-09
CN105143223B (zh) 2018-11-30
MX2015014944A (es) 2016-03-07
KR102336291B1 (ko) 2021-12-07
EP2989101A1 (en) 2016-03-02
BR112015026721B1 (pt) 2022-07-19

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