BR112015013535A2 - pirimido [4,5-b]quinolina-4,5 (3h,10h)-dionas como supressores de mutação sem sentido - Google Patents

pirimido [4,5-b]quinolina-4,5 (3h,10h)-dionas como supressores de mutação sem sentido

Info

Publication number
BR112015013535A2
BR112015013535A2 BR112015013535A BR112015013535A BR112015013535A2 BR 112015013535 A2 BR112015013535 A2 BR 112015013535A2 BR 112015013535 A BR112015013535 A BR 112015013535A BR 112015013535 A BR112015013535 A BR 112015013535A BR 112015013535 A2 BR112015013535 A2 BR 112015013535A2
Authority
BR
Brazil
Prior art keywords
pyrimido
diones
quinoline
nonsense mutation
mutation suppressors
Prior art date
Application number
BR112015013535A
Other languages
English (en)
Inventor
Spanka Carsten
Jacoby Edgar
Reinhardt Juergen
Schmiedeberg Niko
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50030361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015013535(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112015013535A2 publication Critical patent/BR112015013535A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inorganic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo patente de invenção: "pirimido [4,5-b]quinolina-4,5 (3h,10h)-dionas como supressores de mutação sem sentido". a invenção se refere ao composto da fórmula (l); (i); ou um sal do mesmo, em que os substituentes são como definidos na especificação; a sua preparação, a seu uso como medicamento e medicamentos compreendendo-o.
BR112015013535A 2012-12-13 2013-12-12 pirimido [4,5-b]quinolina-4,5 (3h,10h)-dionas como supressores de mutação sem sentido BR112015013535A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261736748P 2012-12-13 2012-12-13
PCT/IB2013/060859 WO2014091446A1 (en) 2012-12-13 2013-12-12 Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors

Publications (1)

Publication Number Publication Date
BR112015013535A2 true BR112015013535A2 (pt) 2017-07-11

Family

ID=50030361

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015013535A BR112015013535A2 (pt) 2012-12-13 2013-12-12 pirimido [4,5-b]quinolina-4,5 (3h,10h)-dionas como supressores de mutação sem sentido

Country Status (24)

Country Link
US (2) US9649314B2 (pt)
EP (1) EP2931282B1 (pt)
JP (1) JP6076498B2 (pt)
KR (1) KR101760586B1 (pt)
CN (2) CN107569487A (pt)
AP (1) AP2015008441A0 (pt)
AU (1) AU2013358591B2 (pt)
BR (1) BR112015013535A2 (pt)
CA (1) CA2890692A1 (pt)
CL (1) CL2015001610A1 (pt)
CR (1) CR20150314A (pt)
CU (1) CU20150061A7 (pt)
EA (1) EA028673B1 (pt)
ES (1) ES2709034T3 (pt)
HK (1) HK1209637A1 (pt)
IL (1) IL239244A0 (pt)
IN (1) IN2015DN03998A (pt)
MA (1) MA38157A1 (pt)
MX (1) MX363437B (pt)
PE (1) PE20151062A1 (pt)
PH (1) PH12015501216A1 (pt)
SG (1) SG11201503684WA (pt)
TN (1) TN2015000262A1 (pt)
WO (1) WO2014091446A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013358591B2 (en) 2012-12-13 2016-08-25 Novartis Ag Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors
CN106459041B (zh) * 2014-06-03 2018-10-16 诺华股份有限公司 嘧啶并[4,5-b]喹啉-4,5(3H,10H)-二酮衍生物
CN106414443B (zh) * 2014-06-03 2018-10-26 诺华股份有限公司 吡啶并嘧啶二酮衍生物
JP6343034B2 (ja) * 2014-06-03 2018-06-13 ノバルティス アーゲー ナフチリジンジオン誘導体
EP3442512A4 (en) * 2016-04-15 2020-07-22 The UAB Research Foundation METHODS AND COMPOUNDS FOR STIMULATING THE TRANSLECTURE OF PREMATURE TERMINATION CODONS
WO2019173437A1 (en) * 2018-03-06 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Positive allosteric modulators of dopamine 1 receptor and method of use thereof
WO2019225625A1 (ja) * 2018-05-23 2019-11-28 京都薬品工業株式会社 リードスルー誘導剤およびその医薬用途
MX2023002850A (es) 2020-09-10 2023-07-07 Precirix N V Fragmento de anticuerpo contra proteina activadora de fibroblastos (fap).
CA3208313A1 (en) 2021-01-13 2022-07-21 Monte Rosa Therapeutics Ag Isoindolinone compounds
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2884170B2 (ja) * 1989-08-24 1999-04-19 株式会社フジモト・ブラザーズ ５−デアザフラビン系化合物を有効成分とする制癌剤
WO1996028444A1 (en) * 1995-03-15 1996-09-19 Pfizer Inc. 5,10-DIHYDROPYRIMIDO[4,5-b]QUINOLIN-4(1H)-ONE TYROSINE KINASE INHIBITORS
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
AU2003249244A1 (en) 2002-07-15 2004-02-02 Combinatorx, Incorporated Methods for the treatment of neoplasms
EP1631260A2 (en) 2003-02-28 2006-03-08 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
ES2926542T3 (es) 2003-04-11 2022-10-26 Ptc Therapeutics Inc Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para supresión de mutaciones finalizadoras y el tratamiento de enfermedades
LT2390255T (lt) 2006-04-03 2016-10-25 Technion Research & Development Foundation Ltd. Nauji aminoglikozidai ir jų panaudojimas genetinių sutrikimų gydyme
AU2007288198A1 (en) 2006-08-23 2008-02-28 Neurogen Corporation Haloalkyl-substituted pyrimidinone derivatives
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
EP2422817A1 (en) 2010-07-29 2012-02-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Flavin-nucleic acid ligand conjugates
PL2600865T3 (pl) 2010-08-05 2019-05-31 Institut National De La Sante Et De La Rech Medicale Związek użyteczny do leczenia chorób, w których pośredniczy mutacja nonsensowna oraz kompozycje farmaceutyczne zawierające wymieniony związek
AU2013358591B2 (en) 2012-12-13 2016-08-25 Novartis Ag Pyrimido [4,5-b]quinoline-4,5 (3H,10H)-diones as nonsense mutation suppressors

Also Published As

Publication number Publication date
CN104837490B (zh) 2017-10-03
TN2015000262A1 (en) 2016-10-03
US9649314B2 (en) 2017-05-16
PE20151062A1 (es) 2015-08-05
EA028673B1 (ru) 2017-12-29
US20170266189A1 (en) 2017-09-21
IL239244A0 (en) 2015-07-30
WO2014091446A1 (en) 2014-06-19
CN107569487A (zh) 2018-01-12
US20150335646A1 (en) 2015-11-26
EP2931282A1 (en) 2015-10-21
KR20150092306A (ko) 2015-08-12
MX363437B (es) 2019-03-22
EA201591105A1 (ru) 2015-10-30
PH12015501216A1 (en) 2015-08-17
CN104837490A (zh) 2015-08-12
HK1209637A1 (en) 2016-04-08
IN2015DN03998A (pt) 2015-10-02
SG11201503684WA (en) 2015-06-29
AU2013358591A1 (en) 2015-05-28
JP6076498B2 (ja) 2017-02-08
MA38157A1 (fr) 2016-12-30
CA2890692A1 (en) 2014-06-19
AP2015008441A0 (en) 2015-05-31
JP2016503003A (ja) 2016-02-01
MX2015007562A (es) 2015-10-14
KR101760586B1 (ko) 2017-07-21
CU20150061A7 (es) 2015-12-23
EP2931282B1 (en) 2018-10-31
ES2709034T3 (es) 2019-04-12
CR20150314A (es) 2015-08-10
AU2013358591B2 (en) 2016-08-25
CL2015001610A1 (es) 2015-08-07

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements