MX2015017446A - Nuevos derivados de amidinourea macrociclica, metodos de preparacion y usos de los mismos como inhibidores de quitinasa. - Google Patents

Nuevos derivados de amidinourea macrociclica, metodos de preparacion y usos de los mismos como inhibidores de quitinasa.

Info

Publication number
MX2015017446A
MX2015017446A MX2015017446A MX2015017446A MX2015017446A MX 2015017446 A MX2015017446 A MX 2015017446A MX 2015017446 A MX2015017446 A MX 2015017446A MX 2015017446 A MX2015017446 A MX 2015017446A MX 2015017446 A MX2015017446 A MX 2015017446A
Authority
MX
Mexico
Prior art keywords
preparation
methods
chitinase inhibitors
new macrocyclic
derivatives
Prior art date
Application number
MX2015017446A
Other languages
English (en)
Other versions
MX363622B (es
Inventor
Sanfilippo Stefania
Botta Maurizio
Maccari Giorgio
DE LUCA Filomena
DEODATO Davide
Posteraro Brunella
SANGUINETTI Maurizio
Denis DOCQUIER Jean-
Original Assignee
Cygnet Biosciences B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnet Biosciences B V filed Critical Cygnet Biosciences B V
Publication of MX2015017446A publication Critical patent/MX2015017446A/es
Publication of MX363622B publication Critical patent/MX363622B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de amidinourea macricíclica de la fórmula 8, métodos de preparación y usos de los mismos, composiciones farmacéuticas en particular para ser utilizadas como inhibidores de la quitinasa en el tratamiento de una infección micótica.
MX2015017446A 2013-06-18 2014-06-18 Nuevos derivados de amidinourea macrociclica, metodos de preparacion y usos de los mismos como inhibidores de quitinasa. MX363622B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361836401P 2013-06-18 2013-06-18
PCT/EP2014/062896 WO2014202697A1 (en) 2013-06-18 2014-06-18 New macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors

Publications (2)

Publication Number Publication Date
MX2015017446A true MX2015017446A (es) 2016-08-12
MX363622B MX363622B (es) 2019-03-28

Family

ID=50979767

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015017446A MX363622B (es) 2013-06-18 2014-06-18 Nuevos derivados de amidinourea macrociclica, metodos de preparacion y usos de los mismos como inhibidores de quitinasa.

Country Status (10)

Country Link
US (1) US10071975B2 (es)
EP (1) EP3010896B1 (es)
JP (1) JP6586416B2 (es)
CN (1) CN105612147B (es)
AU (1) AU2014283281C1 (es)
BR (1) BR112015031820A2 (es)
CA (1) CA2915767A1 (es)
MX (1) MX363622B (es)
PT (1) PT3010896T (es)
WO (1) WO2014202697A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9135200B2 (en) * 2013-06-28 2015-09-15 Futurewei Technologies, Inc. System and method for extended peripheral component interconnect express fabrics
EP3854789A1 (en) 2020-01-22 2021-07-28 Cygnet Biosciences B.V. Macrocyclic compounds useful as chitinase inhibitors
CN113773233B (zh) * 2021-09-18 2022-05-06 中国农业大学 一种甲基胍基脲衍生物及其制备方法与应用
CN115754090B (zh) * 2022-12-15 2023-08-29 华夏生生药业(北京)有限公司 一种lc-ms检测氟康唑相关杂质的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1114155A (en) * 1964-08-24 1968-05-15 Evans Medical Ltd Guanidino derivatives
PL2274290T3 (pl) 2008-03-13 2013-03-29 Univ Degli Studi Di Siena Cykliczne pochodne guanidyny i ich zastosowania

Also Published As

Publication number Publication date
US10071975B2 (en) 2018-09-11
EP3010896B1 (en) 2017-11-01
AU2014283281C1 (en) 2019-01-24
JP6586416B2 (ja) 2019-10-02
CA2915767A1 (en) 2014-12-24
EP3010896A1 (en) 2016-04-27
MX363622B (es) 2019-03-28
CN105612147B (zh) 2018-06-05
US20160137617A1 (en) 2016-05-19
JP2016522236A (ja) 2016-07-28
BR112015031820A2 (pt) 2017-07-25
PT3010896T (pt) 2018-03-07
AU2014283281A1 (en) 2016-02-04
CN105612147A (zh) 2016-05-25
WO2014202697A1 (en) 2014-12-24
AU2014283281B2 (en) 2018-10-04

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