BR112015003592A2 - derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas - Google Patents
derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianasInfo
- Publication number
- BR112015003592A2 BR112015003592A2 BR112015003592A BR112015003592A BR112015003592A2 BR 112015003592 A2 BR112015003592 A2 BR 112015003592A2 BR 112015003592 A BR112015003592 A BR 112015003592A BR 112015003592 A BR112015003592 A BR 112015003592A BR 112015003592 A2 BR112015003592 A2 BR 112015003592A2
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- bacterial infections
- octan
- diazabicyclo
- derivatives
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 3
- LTBMTKNTTYEJSD-UHFFFAOYSA-N 1,6-diazabicyclo[3.2.1]octan-7-one Chemical class C1N2C(=O)NC1CCC2 LTBMTKNTTYEJSD-UHFFFAOYSA-N 0.000 title 1
- ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 2-octanone Chemical class CCCCCCC(C)=O ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
resumo patente de invenção: "derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas". a presente invenção a compostos de fórmula (i), sua preparação e uso na prevenção ou tratamento de infecções bacterianas são descritos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2471MU2012 | 2012-08-25 | ||
PCT/IB2013/053092 WO2014033560A1 (en) | 2012-08-25 | 2013-04-19 | 1,6- diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112015003592A2 true BR112015003592A2 (pt) | 2017-07-04 |
BR112015003592B1 BR112015003592B1 (pt) | 2020-04-14 |
Family
ID=54187095
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015003592A BR112015003592B1 (pt) | 2012-08-25 | 2013-04-19 | derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona e seu uso no tratamento de infecções bacterianas |
Country Status (14)
Country | Link |
---|---|
US (5) | US20150203503A1 (pt) |
EP (2) | EP3360877B1 (pt) |
JP (2) | JP6329147B2 (pt) |
KR (1) | KR101946107B1 (pt) |
CN (1) | CN104768951B (pt) |
AU (2) | AU2013308127B2 (pt) |
BR (1) | BR112015003592B1 (pt) |
CA (1) | CA2881169C (pt) |
ES (1) | ES2672100T3 (pt) |
MX (1) | MX368346B (pt) |
NZ (1) | NZ626314A (pt) |
RU (1) | RU2614418C2 (pt) |
WO (1) | WO2014033560A1 (pt) |
ZA (1) | ZA201500970B (pt) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
MX366948B (es) * | 2012-05-30 | 2019-07-30 | Meiji Seika Pharma Co Ltd | Nuevo inhibidor de beta-lactamasa y proceso para prepararlo. |
CA2881169C (en) * | 2012-08-25 | 2020-06-16 | Wockhardt Limited | 1,6-diazabicyclo [3,2,1]octan - 7 - one derivatives and their use in the treatment of bacterial infections |
UA111925C2 (uk) * | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
JP6617029B2 (ja) * | 2013-10-08 | 2019-12-04 | Meiji Seikaファルマ株式会社 | ジアザビシクロオクタン誘導体の結晶とその製造法 |
WO2015063714A1 (en) * | 2013-10-30 | 2015-05-07 | Wockhardt Limited | Pharmaceutical compositions comprising antibacterial agents |
US9604986B2 (en) | 2013-11-26 | 2017-03-28 | Wockhardt Limited | Polymorphs and process for preparation of (2S, 5R)-7-oxo-N-[(2S)-pyrrolidin-2-yl-methyloxy]-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide |
US20160296502A1 (en) * | 2013-11-26 | 2016-10-13 | Wockhardt Limited | Antibacterial compositions |
IN2014MU00194A (pt) * | 2014-01-21 | 2015-08-28 | Wockhardt Ltd | |
SG11201606711UA (en) | 2014-03-24 | 2016-10-28 | Novartis Ag | Monobactam organic compounds for the treatment of bacterial infections |
KR20160130824A (ko) * | 2014-03-29 | 2016-11-14 | 욱크하르트 리미티드 | 세페파임 또는 술박탐을 포함하는 제약학적 조성물 |
RS58429B1 (sr) | 2014-11-17 | 2019-04-30 | Entasis Therapeutics Ltd | Kombinovana terapija za lečenje rezistentnih bakterijskih infekcija |
WO2016128867A1 (en) * | 2015-02-12 | 2016-08-18 | Wockhardt Limited | Azetidinone containing compounds and their use in treatment of bacterial infections |
EP3075734A1 (en) * | 2015-03-31 | 2016-10-05 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
MX2017012539A (es) | 2015-03-31 | 2018-09-28 | Mutabilis | Compuestos heterociclicos y su uso en la prevencion o tratamiento de las infecciones bacterianas. |
WO2017002086A1 (en) * | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
WO2017002089A1 (en) * | 2015-07-02 | 2017-01-05 | Wockhardt Limited | Nitrogen containing bicyclic compounds and their use in treatment of bacterial infections |
US20190077802A1 (en) * | 2015-10-06 | 2019-03-14 | Wockhardt Limited | Difluoro-(2-substituted carbamoyl-1,6-diaza-bicyclo [3.2.1] oct-6-yloxy) acetic acid compounds and their use in treatment of bacterial infections |
US20180282331A1 (en) * | 2015-11-09 | 2018-10-04 | Wockhardt Limited | 7-Oxo -6-(sulfooxy)- 1,6-diazabicyclo [3.2.1] octane containing compounds and their use in treatment of bacterial infections (changed by PCT to: 7-OXO -6-(SULFOOXY)- 1,6-DIAZABICYCLO [3.2.1] OCTANE CONTAINING COMPOUNDS AND THEIR USE IN TREATMENT OF BACTERIAL INFECTIONS |
CA3026322C (en) * | 2016-06-03 | 2023-08-15 | Medshine Discovery Inc. | Novel b-lactamase inhibitors |
WO2017206948A1 (zh) * | 2016-06-03 | 2017-12-07 | 南京明德新药研发股份有限公司 | 新型二氮杂二环β-内酰胺酶抑制剂 |
WO2017216763A1 (en) * | 2016-06-17 | 2017-12-21 | Wockhardt Limited | N-phenylalkoxy-7-oxo-6-sulfooxy-1,6-diazabicyclo[3.2.1]octane-2-carboxamide derivatives and their use as antibacterial agents |
CN114591223A (zh) | 2016-09-16 | 2022-06-07 | 恩塔西斯治疗有限公司 | β-内酰胺酶抑制剂化合物 |
JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
WO2018141991A1 (en) * | 2017-02-06 | 2018-08-09 | Mutabilis | Novel heterocyclic compounds and their use in preventing or treating bacterial infections |
JP7012924B2 (ja) * | 2017-03-02 | 2022-02-15 | ウォックハート リミテッド | 抗菌化合物としての複素環誘導体 |
US10500195B2 (en) * | 2017-03-02 | 2019-12-10 | Wockhardt Limited | Antibacterial compounds |
TWI791018B (zh) | 2017-05-08 | 2023-02-01 | 美商安特西醫療公司 | 治療細菌感染之化合物及方法 |
WO2019064065A1 (en) * | 2017-09-27 | 2019-04-04 | F. Hoffmann-La Roche Ag | PHARMACEUTICAL FORMS OF DIAZABICYCLOOCTANE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
TW201920174A (zh) | 2017-09-27 | 2019-06-01 | 瑞士商羅氏大藥廠股份有限公司 | 二氮雜雙環辛烷衍生物之醫藥形式及其製法 |
CA3076959A1 (en) | 2017-09-27 | 2019-04-04 | Fedora Pharmaceuticals Inc. | Crystalline forms of diazabicyclooctane derivatives and production process thereof |
EP3719020B1 (en) * | 2017-12-01 | 2022-09-21 | Qilu Pharmaceutical Co., Ltd. | Crystal form of beta-lactamase inhibitor and preparation method therefor |
US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
US11865108B2 (en) * | 2019-10-18 | 2024-01-09 | Wockhardt Limited | Nitrogen containing bicyclic compounds |
WO2021165927A1 (en) * | 2020-02-21 | 2021-08-26 | Wockhardt Bio Ag | 2-cyanopyrroldines, -piperidines or -dazepines as hyperglycemic agents |
WO2022047790A1 (en) * | 2020-09-07 | 2022-03-10 | Ningxia Academy Of Agriculture And Forestry Sciences | Amidine substituted bicyclic compounds, their preparation, their use as antibacterial agents and beta-lactamase inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3615473A1 (de) | 1986-05-07 | 1987-11-12 | Basf Ag | Verfahren zur herstellung von o-substituierten hydroxylaminen |
US5925659A (en) * | 1996-05-07 | 1999-07-20 | Merck & Co., Inc. | Antibacterial agents |
FR2803592A1 (fr) * | 2000-01-06 | 2001-07-13 | Aventis Cropscience Sa | Nouveaux derives de l'acide 3-hydroxypicolinique, leur procede de preparation et compositions fongicides les contenant. |
FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
DE10256976A1 (de) * | 2002-12-05 | 2004-06-24 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Hydroxamsäuren als Methionin-Aminopeptidase (MAP) Inhibitoren |
FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
UA101966C2 (en) * | 2008-01-18 | 2013-05-27 | Мерк Шарп Енд Доме Корп. | Beta-lactamase inhibitors |
FR2930553B1 (fr) * | 2008-04-29 | 2010-05-21 | Novexel | Composes azabicycliques, leur preparation et leur utilisation comme medicaments, notamment inhibiteurs de beta-lactamases |
JP5455913B2 (ja) * | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−n−オキシドを有する新規ヒドロキサム酸誘導体 |
FR2936798B1 (fr) * | 2008-10-03 | 2012-09-28 | Novexel | Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens. |
US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
MX366948B (es) * | 2012-05-30 | 2019-07-30 | Meiji Seika Pharma Co Ltd | Nuevo inhibidor de beta-lactamasa y proceso para prepararlo. |
CA2881169C (en) * | 2012-08-25 | 2020-06-16 | Wockhardt Limited | 1,6-diazabicyclo [3,2,1]octan - 7 - one derivatives and their use in the treatment of bacterial infections |
-
2013
- 2013-04-19 CA CA2881169A patent/CA2881169C/en not_active Expired - Fee Related
- 2013-04-19 EP EP18162588.0A patent/EP3360877B1/en active Active
- 2013-04-19 JP JP2015529143A patent/JP6329147B2/ja not_active Expired - Fee Related
- 2013-04-19 BR BR112015003592A patent/BR112015003592B1/pt not_active IP Right Cessation
- 2013-04-19 AU AU2013308127A patent/AU2013308127B2/en not_active Ceased
- 2013-04-19 KR KR1020157005080A patent/KR101946107B1/ko active IP Right Grant
- 2013-04-19 CN CN201380044430.7A patent/CN104768951B/zh not_active Expired - Fee Related
- 2013-04-19 NZ NZ626314A patent/NZ626314A/en not_active IP Right Cessation
- 2013-04-19 RU RU2015110500A patent/RU2614418C2/ru not_active IP Right Cessation
- 2013-04-19 WO PCT/IB2013/053092 patent/WO2014033560A1/en active Application Filing
- 2013-04-19 ES ES13726298.6T patent/ES2672100T3/es active Active
- 2013-04-19 EP EP13726298.6A patent/EP2961751B1/en not_active Not-in-force
- 2013-04-19 MX MX2015002177A patent/MX368346B/es active IP Right Grant
- 2013-04-19 US US14/365,064 patent/US20150203503A1/en not_active Abandoned
-
2015
- 2015-02-11 ZA ZA2015/00970A patent/ZA201500970B/en unknown
- 2015-07-23 AU AU2015205914A patent/AU2015205914B2/en not_active Ceased
-
2016
- 2016-03-06 US US15/062,148 patent/US9732081B2/en not_active Expired - Fee Related
- 2016-07-04 US US15/201,540 patent/US20160311822A1/en not_active Abandoned
-
2017
- 2017-05-08 JP JP2017092573A patent/JP6386132B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-17 US US15/898,453 patent/US10519155B2/en not_active Expired - Fee Related
-
2019
- 2019-11-07 US US16/677,316 patent/US20200071328A1/en not_active Abandoned
Also Published As
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