BR112015022861A2 - inibidores de bromodomínio - Google Patents

inibidores de bromodomínio

Info

Publication number
BR112015022861A2
BR112015022861A2 BR112015022861A BR112015022861A BR112015022861A2 BR 112015022861 A2 BR112015022861 A2 BR 112015022861A2 BR 112015022861 A BR112015022861 A BR 112015022861A BR 112015022861 A BR112015022861 A BR 112015022861A BR 112015022861 A2 BR112015022861 A2 BR 112015022861A2
Authority
BR
Brazil
Prior art keywords
bromodomain inhibitors
compounds
formula
diseases
aids
Prior art date
Application number
BR112015022861A
Other languages
English (en)
Other versions
BR112015022861A8 (pt
Inventor
Liu Dachun
S Sheppard George
H Holms James
K Pratt John
F Mcdaniel Keith
A Hasvold Lisa
Mantei Robert
D Fidanze Steven
Le Wang
Mcclellan William
Dai Yujia
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of BR112015022861A2 publication Critical patent/BR112015022861A2/pt
Publication of BR112015022861A8 publication Critical patent/BR112015022861A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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Abstract

resumo "inibidores de bromodomínio" a presente invenção refere-se a compostos de fórmula (i) (i) onde r1, r2, a1, a2, a3, a4, x, e y têm qualquer um dos valores definidos na especificação, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis co-mo agentes no tratamento de doenças e condições, incluindo doenças inflamató-rias, câncer, e aids. são também fornecidas composições farmacêuticas compre-endendo um ou mais compostos de fórmula (i).
BR112015022861A 2013-03-11 2014-03-11 inibidores de bromodomínio BR112015022861A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776530P 2013-03-11 2013-03-11
PCT/US2014/023437 WO2014164771A1 (en) 2013-03-11 2014-03-11 Bromodomain inhibitors

Publications (2)

Publication Number Publication Date
BR112015022861A2 true BR112015022861A2 (pt) 2017-07-18
BR112015022861A8 BR112015022861A8 (pt) 2019-11-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022861A BR112015022861A8 (pt) 2013-03-11 2014-03-11 inibidores de bromodomínio

Country Status (9)

Country Link
US (1) US9050346B2 (pt)
EP (1) EP2970262A1 (pt)
JP (1) JP2016512524A (pt)
CN (1) CN105164127A (pt)
AU (1) AU2014249025A1 (pt)
BR (1) BR112015022861A8 (pt)
CA (1) CA2904048A1 (pt)
MX (1) MX2015012005A (pt)
WO (1) WO2014164771A1 (pt)

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