BR112014016233A8 - inibidores de bromodomínio - Google Patents

inibidores de bromodomínio

Info

Publication number
BR112014016233A8
BR112014016233A8 BR112014016233A BR112014016233A BR112014016233A8 BR 112014016233 A8 BR112014016233 A8 BR 112014016233A8 BR 112014016233 A BR112014016233 A BR 112014016233A BR 112014016233 A BR112014016233 A BR 112014016233A BR 112014016233 A8 BR112014016233 A8 BR 112014016233A8
Authority
BR
Brazil
Prior art keywords
bromodomain inhibitors
formula
compounds
diseases
aids
Prior art date
Application number
BR112014016233A
Other languages
English (en)
Other versions
BR112014016233B1 (pt
BR112014016233A2 (pt
Inventor
K Wada Carol
Liu Dachun
S Sheppard George
H Holms James
K Pratt John
F Mcdaniel Keith
Wang Le
Hasvold Lisa
A Mantei Robert
D Fidanze Steven
M Kati Warren
J Mcclellan William
Dai Yujia
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of BR112014016233A2 publication Critical patent/BR112014016233A2/pt
Publication of BR112014016233A8 publication Critical patent/BR112014016233A8/pt
Publication of BR112014016233B1 publication Critical patent/BR112014016233B1/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Abstract

resumo a presente invenção fornece compostos de fórmula (i) (i) em que a1, a2, a3, a4, x1, x2, y1, l1, g1, rx e ry tem quaisquer dos valores definidos dos mesmos na especificação, e sais farmaceuticamente aceitáveis dos mesmos, que são úteis como agentes no tratamento de doenças e condições, incluindo doenças inflamatórias, câncer, e aids. são também fornecidas composições farmacêuticas compreendendo um ou mais compostos de fórmula (i).
BR112014016233A 2011-12-30 2012-12-11 inibidores de bromodomínio BR112014016233B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2011/002224 WO2013097052A1 (en) 2011-12-30 2011-12-30 Bromodomain inhibitors
PCT/CN2012/086357 WO2013097601A1 (en) 2011-12-30 2012-12-11 Bromodomain inhibitors

Publications (3)

Publication Number Publication Date
BR112014016233A2 BR112014016233A2 (pt) 2017-06-13
BR112014016233A8 true BR112014016233A8 (pt) 2017-07-04
BR112014016233B1 BR112014016233B1 (pt) 2020-04-28

Family

ID=48696151

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014016233A BR112014016233B1 (pt) 2011-12-30 2012-12-11 inibidores de bromodomínio

Country Status (39)

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US (5) US9296741B2 (pt)
EP (2) EP3360874A1 (pt)
JP (3) JP6117238B2 (pt)
KR (1) KR102008975B1 (pt)
CN (2) CN106986872B (pt)
AR (2) AR089527A1 (pt)
AU (3) AU2012361967B2 (pt)
BR (1) BR112014016233B1 (pt)
CA (1) CA2859619C (pt)
CL (1) CL2014001752A1 (pt)
CO (1) CO7020912A2 (pt)
CR (1) CR20140332A (pt)
CY (1) CY1120287T1 (pt)
DK (1) DK2797918T3 (pt)
DO (1) DOP2014000152A (pt)
EC (1) ECSP14011359A (pt)
ES (1) ES2665890T3 (pt)
GT (1) GT201400133A (pt)
HK (3) HK1203508A1 (pt)
HR (1) HRP20180357T1 (pt)
HU (1) HUE038391T2 (pt)
IL (1) IL233454A (pt)
LT (1) LT2797918T (pt)
ME (1) ME03028B (pt)
MX (1) MX341740B (pt)
NO (1) NO2797918T3 (pt)
PE (1) PE20142340A1 (pt)
PH (1) PH12014501469B1 (pt)
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