MX341740B - Inhibidores de bromodominio. - Google Patents

Inhibidores de bromodominio.

Info

Publication number
MX341740B
MX341740B MX2014008143A MX2014008143A MX341740B MX 341740 B MX341740 B MX 341740B MX 2014008143 A MX2014008143 A MX 2014008143A MX 2014008143 A MX2014008143 A MX 2014008143A MX 341740 B MX341740 B MX 341740B
Authority
MX
Mexico
Prior art keywords
bromodomain inhibitors
compounds
formula
diseases
aids
Prior art date
Application number
MX2014008143A
Other languages
English (en)
Other versions
MX2014008143A (es
Inventor
M Kati Warren
K Pratt John
Wang Le
Dai Yujia
Hasvold Lisa
A Mantei Robert
J Mcclellan William
F Mcdaniel Keith
D Fidanze Steven
H Holms James
Liu Dachun
S Sheppard George
K Wada Carol
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2014008143A publication Critical patent/MX2014008143A/es
Publication of MX341740B publication Critical patent/MX341740B/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Virology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
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Abstract

La presente invención provee compuestos de fórmula (I) en donde A1, A2, A3, A4, X1, X2, Y1, L1, G1, Rx y Ry tienen cualquiera de los valores definidos en la especificación, y sales farmacéuticamente aceptables de los mismos, que son útiles como agentes para el tratamiento de enfermedades y afecciones que incluyen enfermedades inflamatorias, cáncer y SIDA. También se proveen composiciones farmacéuticas que comprenden uno o más compuestos de fórmula (I).
MX2014008143A 2011-12-30 2012-12-11 Inhibidores de bromodominio. MX341740B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2011/002224 WO2013097052A1 (en) 2011-12-30 2011-12-30 Bromodomain inhibitors
PCT/CN2012/086357 WO2013097601A1 (en) 2011-12-30 2012-12-11 Bromodomain inhibitors

Publications (2)

Publication Number Publication Date
MX2014008143A MX2014008143A (es) 2014-11-25
MX341740B true MX341740B (es) 2016-08-31

Family

ID=48696151

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008143A MX341740B (es) 2011-12-30 2012-12-11 Inhibidores de bromodominio.

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US (5) US9296741B2 (es)
EP (2) EP2797918B1 (es)
JP (3) JP6117238B2 (es)
KR (1) KR102008975B1 (es)
CN (2) CN104136435B (es)
AR (2) AR089527A1 (es)
AU (3) AU2012361967B2 (es)
BR (1) BR112014016233B1 (es)
CA (1) CA2859619C (es)
CL (1) CL2014001752A1 (es)
CO (1) CO7020912A2 (es)
CR (1) CR20140332A (es)
CY (1) CY1120287T1 (es)
DK (1) DK2797918T3 (es)
DO (1) DOP2014000152A (es)
EC (1) ECSP14011359A (es)
ES (1) ES2665890T3 (es)
GT (1) GT201400133A (es)
HK (3) HK1203508A1 (es)
HR (1) HRP20180357T1 (es)
HU (1) HUE038391T2 (es)
IL (1) IL233454A (es)
LT (1) LT2797918T (es)
ME (1) ME03028B (es)
MX (1) MX341740B (es)
NO (1) NO2797918T3 (es)
PE (1) PE20142340A1 (es)
PH (1) PH12014501469A1 (es)
PL (1) PL2797918T3 (es)
PT (1) PT2797918T (es)
RS (1) RS56978B1 (es)
RU (3) RU2671571C1 (es)
SG (1) SG11201403717WA (es)
SI (1) SI2797918T1 (es)
TW (1) TWI602815B (es)
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