EA201591105A1 - ПИРИМИДО[4,5-b]ХИНОЛИН-4,5-(3H,10H)-ДИОНЫ В КАЧЕСТВЕ СУПРЕССОРОВ НОНСЕНС МУТАЦИЙ - Google Patents

ПИРИМИДО[4,5-b]ХИНОЛИН-4,5-(3H,10H)-ДИОНЫ В КАЧЕСТВЕ СУПРЕССОРОВ НОНСЕНС МУТАЦИЙ

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Publication number
EA201591105A1
EA201591105A1 EA201591105A EA201591105A EA201591105A1 EA 201591105 A1 EA201591105 A1 EA 201591105A1 EA 201591105 A EA201591105 A EA 201591105A EA 201591105 A EA201591105 A EA 201591105A EA 201591105 A1 EA201591105 A1 EA 201591105A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nonsens
supressors
pyrimido
diones
quinolin
Prior art date
Application number
EA201591105A
Other languages
English (en)
Other versions
EA028673B1 (ru
Inventor
Эдгар Якоби
Юрген Райнхардт
Нико Шмидеберг
Карстен Шпанка
Original Assignee
Новартис Аг
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50030361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201591105(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201591105A1 publication Critical patent/EA201591105A1/ru
Publication of EA028673B1 publication Critical patent/EA028673B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inorganic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение относится к соединению формулы (I)или его соли, где заместители имеют значения, определенные в описании изобретения; его получению, его применению в качестве лекарственного средства и к лекарственным средствам, включающим такое соединение.
EA201591105A 2012-12-13 2013-12-12 ПИРИМИДО[4,5-b]ХИНОЛИН-4,5(3H,10H)ДИОНЫ В КАЧЕСТВЕ СУПРЕССОРОВ НОНСЕНС МУТАЦИЙ EA028673B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261736748P 2012-12-13 2012-12-13
PCT/IB2013/060859 WO2014091446A1 (en) 2012-12-13 2013-12-12 Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors

Publications (2)

Publication Number Publication Date
EA201591105A1 true EA201591105A1 (ru) 2015-10-30
EA028673B1 EA028673B1 (ru) 2017-12-29

Family

ID=50030361

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591105A EA028673B1 (ru) 2012-12-13 2013-12-12 ПИРИМИДО[4,5-b]ХИНОЛИН-4,5(3H,10H)ДИОНЫ В КАЧЕСТВЕ СУПРЕССОРОВ НОНСЕНС МУТАЦИЙ

Country Status (24)

Country Link
US (2) US9649314B2 (ru)
EP (1) EP2931282B1 (ru)
JP (1) JP6076498B2 (ru)
KR (1) KR101760586B1 (ru)
CN (2) CN104837490B (ru)
AP (1) AP2015008441A0 (ru)
AU (1) AU2013358591B2 (ru)
BR (1) BR112015013535A2 (ru)
CA (1) CA2890692A1 (ru)
CL (1) CL2015001610A1 (ru)
CR (1) CR20150314A (ru)
CU (1) CU20150061A7 (ru)
EA (1) EA028673B1 (ru)
ES (1) ES2709034T3 (ru)
HK (1) HK1209637A1 (ru)
IL (1) IL239244A0 (ru)
IN (1) IN2015DN03998A (ru)
MA (1) MA38157A1 (ru)
MX (1) MX363437B (ru)
PE (1) PE20151062A1 (ru)
PH (1) PH12015501216A1 (ru)
SG (1) SG11201503684WA (ru)
TN (1) TN2015000262A1 (ru)
WO (1) WO2014091446A1 (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2931282B1 (en) 2012-12-13 2018-10-31 Novartis AG Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors
MY178379A (en) * 2014-06-03 2020-10-09 Novartis Ag Naphthyridinedione derivatives as suppressors of non-sense mutations
EP3152207B1 (en) 2014-06-03 2019-05-08 Novartis AG Pyridopyrimidinedione derivatives as suppressors of non-sens mutations
EP3152208B1 (en) * 2014-06-03 2019-05-08 Novartis AG Pyrimido[4,5-b]quinoline-4,5(3h,10h)-dione derivatives as suppressors of non-sens mutations
WO2017181193A2 (en) * 2016-04-15 2017-10-19 The Uab Research Foundation Methods and compounds for stimulating read-through of premature termination codons
WO2019173437A1 (en) * 2018-03-06 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Positive allosteric modulators of dopamine 1 receptor and method of use thereof
WO2019225625A1 (ja) * 2018-05-23 2019-11-28 京都薬品工業株式会社 リードスルー誘導剤およびその医薬用途
WO2022053651A2 (en) 2020-09-10 2022-03-17 Precirix N.V. Antibody fragment against fap
WO2022152821A1 (en) 2021-01-13 2022-07-21 Monte Rosa Therapeutics Ag Isoindolinone compounds
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
JP2884170B2 (ja) 1989-08-24 1999-04-19 株式会社フジモト・ブラザーズ ５−デアザフラビン系化合物を有効成分とする制癌剤
US5908930A (en) * 1995-03-15 1999-06-01 Pfizer Inc. 5,10-dihydropyrimdo 4,5-b!quinolin-4(1H)-one tyrosine kinase inhibitors
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
WO2004006906A2 (en) 2002-07-15 2004-01-22 Combinatorx, Incorporated Methods for the treatment of neoplasms
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
ES2624610T3 (es) 2003-04-11 2017-07-17 Ptc Therapeutics, Inc. Compuestos de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
ES2689539T3 (es) 2006-04-03 2018-11-14 Technion Research & Development Foundation Ltd. Aminoglucósidos novedosos y usos de los mismos en el tratamiento de trastornos genéticos
TW200819454A (en) 2006-08-23 2008-05-01 Neurogen Corp Haloalkyl-substituted pyrimidinone derivatives
JP2011507910A (ja) * 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
EP2422817A1 (en) 2010-07-29 2012-02-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Flavin-nucleic acid ligand conjugates
WO2012016930A1 (en) * 2010-08-05 2012-02-09 Universite De Droit Et Sante De Lille Compound useful for the treatment of nonsense-mutation-mediated diseases and pharmaceutical composition comprising said compound
EP2931282B1 (en) 2012-12-13 2018-10-31 Novartis AG Pyrimido [4,5-b]quinoline-4,5 (3h,10h)-diones as nonsense mutation suppressors

Also Published As

Publication number Publication date
ES2709034T3 (es) 2019-04-12
US20170266189A1 (en) 2017-09-21
PH12015501216A1 (en) 2015-08-17
US9649314B2 (en) 2017-05-16
EA028673B1 (ru) 2017-12-29
JP6076498B2 (ja) 2017-02-08
CU20150061A7 (es) 2015-12-23
AU2013358591B2 (en) 2016-08-25
AU2013358591A1 (en) 2015-05-28
US20150335646A1 (en) 2015-11-26
CN104837490B (zh) 2017-10-03
CL2015001610A1 (es) 2015-08-07
SG11201503684WA (en) 2015-06-29
IL239244A0 (en) 2015-07-30
AP2015008441A0 (en) 2015-05-31
KR20150092306A (ko) 2015-08-12
CA2890692A1 (en) 2014-06-19
HK1209637A1 (en) 2016-04-08
IN2015DN03998A (ru) 2015-10-02
WO2014091446A1 (en) 2014-06-19
EP2931282B1 (en) 2018-10-31
CN104837490A (zh) 2015-08-12
MX2015007562A (es) 2015-10-14
EP2931282A1 (en) 2015-10-21
KR101760586B1 (ko) 2017-07-21
MX363437B (es) 2019-03-22
BR112015013535A2 (pt) 2017-07-11
CR20150314A (es) 2015-08-10
CN107569487A (zh) 2018-01-12
JP2016503003A (ja) 2016-02-01
MA38157A1 (fr) 2016-12-30
TN2015000262A1 (en) 2016-10-03
PE20151062A1 (es) 2015-08-05

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Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU