PE20010546A1 - Uso de una composicion de benzoheterociclos como inhibidores de mek para tratar el dolor cronico - Google Patents

Uso de una composicion de benzoheterociclos como inhibidores de mek para tratar el dolor cronico

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Publication number
PE20010546A1
PE20010546A1 PE2000000704A PE0007042000A PE20010546A1 PE 20010546 A1 PE20010546 A1 PE 20010546A1 PE 2000000704 A PE2000000704 A PE 2000000704A PE 0007042000 A PE0007042000 A PE 0007042000A PE 20010546 A1 PE20010546 A1 PE 20010546A1
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PE
Peru
Prior art keywords
alkyl
cycloalkyl
phenyl
composition
methyl
Prior art date
Application number
PE2000000704A
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English (en)
Inventor
Kevin Lee
Haile Tecle
Alexander James Bridges
Stephen Douglas Barrett
Alistair Dixon
Robert Denham Pinnock
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Warner Lambert Co
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Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20010546A1 publication Critical patent/PE20010546A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

SE REFIERE AL USO DE UNA COMPOSICION QUE COMPRENDE UN INHIBIDOR DE CINASA MEK DE FORMULA I, DONDE: W ES OR1, NR2OR1, NRARB, NR2NRARB, O(CH2)2-4NRARB, NR2(CH2)2-4, R1 ES H, ALQUILO C1-C8, ALQUENILO C3-C8, ALQUINILO C3-C8, CICLOALQUILO C3-C8, FENILO, FENIL(ALQUILO)C1-C4. FENILALQUENILO C3-C4, ENTRE OTROS; R2 ES H, ALQUILO C1-C4, FENILO, CICLOALQUILO C3-C6, HETEROCICLO C3-C6; RA ES H, ALQUILO C1-C6, ALQUENILO C3-C8, ALQUINILO C3-C8, CICLOALQUILO C3-C8, FENILO, (CICLOALQUILO C3-C8)ALQUILO C1-C4, ENTRE OTROS; RB ES H, ALQUILO C1-C8, CICLOALQUILO C3-C8, FENILO; Q ES EL GRUPO a, ENTRE OTROS; R3 ES H, F; R4 ES HALO, NO2, SO2NRo(CH2)2-4NREFE, ENTRE OTROS; T ES ALQUILO C1-C8, CICLOALQUILO C3-C8, ENTRE OTROS; Z ES EL GRUPO iv, ENTRE OTROS; UNO DE R5 Y R6 ES H, METILO Y EL OTRO ES H, ALQUILO C1-C6, ALQUENILO C2-C6, FENILO, ENTRE OTROS; R10 Y R11 SON H, METILO, HALO, NO2. SON COMPUESTOS PREFERIDOS ACIDO 7-FLUORO-6-(4-YODO-2-METIL-FENILAMINO)-1H-BENZOIMIDAZOL-5-CARBOXILICO, ACIDO 7-FLUORO-6-(4-YODO-2-METIL-FENILAMINO)-1H-BENZOIMIDAZOL-5-CARBOXILICO, ENTRE OTROS. LA COMPOSICION PUEDE SER UTIL PARA EL TRATAMIENTO DEL DOLOR CRONICO, NEUROPATICO
PE2000000704A 1999-07-16 2000-07-14 Uso de una composicion de benzoheterociclos como inhibidores de mek para tratar el dolor cronico PE20010546A1 (es)

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US14441899P 1999-07-16 1999-07-16

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EP (1) EP1202731A2 (es)
JP (1) JP2003504398A (es)
KR (1) KR20020015376A (es)
CN (1) CN1358094A (es)
AU (1) AU6068600A (es)
CA (1) CA2377092A1 (es)
CO (1) CO5190704A1 (es)
HU (1) HUP0202319A3 (es)
IL (1) IL147150A0 (es)
PE (1) PE20010546A1 (es)
PL (1) PL352835A1 (es)
WO (1) WO2001005390A2 (es)
ZA (1) ZA200109906B (es)

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