PE20020509A1 - Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih - Google Patents
Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vihInfo
- Publication number
- PE20020509A1 PE20020509A1 PE2001001008A PE2001001008A PE20020509A1 PE 20020509 A1 PE20020509 A1 PE 20020509A1 PE 2001001008 A PE2001001008 A PE 2001001008A PE 2001001008 A PE2001001008 A PE 2001001008A PE 20020509 A1 PE20020509 A1 PE 20020509A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- fluoroalkyl
- poliaza
- aza
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Abstract
SE REFIERE A COMPUESTOS AZA Y POLIAZA-NAFTALENIL CARBOXAMIDAS DE FORMULA I DONDE A ES GRUPO AROMATICO, GRUPOS BICICLICOS; L ES UNA SOLA UNION, -(CH2)1-3, -(CH2)1-2OH, ENTRE OTROS; Q2 ES H, ALQUILO C1-C4, FLUOROALQUILO C1-C4, ENTRE OTROS; Q4 ES H, ALQUILO C1-C4, FLUOROALQUILO C1-C4, -O- ALQUILO C1-C4, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C4, FLUOROALQUILO C1-C4, -O-ALQUILO C1-C4, OH, ENTRE OTROS; R3 Y R4 SON H, HALO, CN, OH, ALQUILO C1-C4, FLUOROALQUILO C1-C4, ENTRE OTROS; R5 ES H, ALQUILO C1-C4, FENILO, ALQUILO C1-C4 SUSTITUIDO CON FENILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-1-(7-{[(4-FLUOROBENCIL)AMINO]CARBONIL}-8-HIDROXI-1,6-NAFTIRIDIN-5-IL)-N-1-,N-2,N-2-TRIMETILETANDIAMIDA, 5-(1,1-DIOXIDO-1,2-TIACINAN-2-IL)-N-(4-FLUOROBENCIL)-8-HIDROXI-1,6-NAFTIRIDIN-7-CARBOXAMIDA, N-(4-FLUOROBENCIL)-5-(1,1,-DIOXIDO-1,2,5-TIADIACEPAN-2-IL)-8-HIDROXI-[1,6]NAFTIRIDIN-7-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON UTILES COMO INHIBIDORES DE LA INTEGRASA DEL VIH UTIL PARA LA PREVENCION Y TRATAMIENTO DEL INICIO DE SIDA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23970700P | 2000-10-12 | 2000-10-12 | |
US28165601P | 2001-04-05 | 2001-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20020509A1 true PE20020509A1 (es) | 2002-06-20 |
Family
ID=26932782
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2001001008A PE20020509A1 (es) | 2000-10-12 | 2001-10-11 | Aza y poliaza-naftalenil carboxamidas utiles como inhibidores de la integrasa del vih |
Country Status (26)
Country | Link |
---|---|
US (2) | US6921759B2 (es) |
EP (1) | EP1326865B1 (es) |
JP (1) | JP4252797B2 (es) |
KR (1) | KR20030036922A (es) |
CN (1) | CN1469878A (es) |
AR (1) | AR033845A1 (es) |
AT (1) | ATE430745T1 (es) |
AU (3) | AU2002211527B2 (es) |
BG (1) | BG107677A (es) |
BR (1) | BR0114610A (es) |
CA (1) | CA2425440C (es) |
CZ (1) | CZ20031028A3 (es) |
DE (1) | DE60138635D1 (es) |
EA (1) | EA200300449A1 (es) |
EE (1) | EE200300145A (es) |
HU (1) | HUP0302367A2 (es) |
IL (1) | IL155089A0 (es) |
IS (1) | IS6760A (es) |
MX (1) | MXPA03003263A (es) |
NO (1) | NO20031672L (es) |
NZ (1) | NZ525088A (es) |
PE (1) | PE20020509A1 (es) |
PL (1) | PL360944A1 (es) |
SK (1) | SK4322003A3 (es) |
WO (2) | WO2002030931A2 (es) |
YU (1) | YU27903A (es) |
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CZ20031028A3 (cs) * | 2000-10-12 | 2003-08-13 | Merck & Co., Inc. | Aza- a polyazanaftalenylkarboxamidy |
CN1336363A (zh) | 2001-07-25 | 2002-02-20 | 张元宾 | 乙酰磺胺酸钾的合成制备方法 |
CA2456155A1 (en) | 2001-08-17 | 2003-02-27 | Merck & Co., Inc. | Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides |
AR036256A1 (es) * | 2001-08-17 | 2004-08-25 | Merck & Co Inc | Sal sodica de un inhibidor de integrasa del vih, procesos para su preparacion, composiciones farmaceuticas que lo contienen y su uso para la manufactura de un medicamento |
ATE355064T1 (de) | 2001-10-26 | 2006-03-15 | Angeletti P Ist Richerche Bio | Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase |
PL212914B1 (pl) | 2001-10-26 | 2012-12-31 | Angeletti P Ist Richerche Bio | N-podstawione hydroksypirymidynonokarboksyamidy jako inhibitory integrazy HIV |
US20050165000A1 (en) * | 2002-04-10 | 2005-07-28 | Robertson Sandra K. | Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant |
-
2001
- 2001-10-09 CZ CZ20031028A patent/CZ20031028A3/cs unknown
- 2001-10-09 AU AU2002211527A patent/AU2002211527B2/en not_active Ceased
- 2001-10-09 AU AU1152702A patent/AU1152702A/xx active Pending
- 2001-10-09 EA EA200300449A patent/EA200300449A1/ru unknown
- 2001-10-09 NZ NZ525088A patent/NZ525088A/en unknown
- 2001-10-09 MX MXPA03003263A patent/MXPA03003263A/es unknown
- 2001-10-09 HU HU0302367A patent/HUP0302367A2/hu unknown
- 2001-10-09 KR KR10-2003-7005140A patent/KR20030036922A/ko not_active Application Discontinuation
- 2001-10-09 YU YU27903A patent/YU27903A/sh unknown
- 2001-10-09 CN CNA018172970A patent/CN1469878A/zh active Pending
- 2001-10-09 DE DE60138635T patent/DE60138635D1/de not_active Expired - Lifetime
- 2001-10-09 BR BR0114610-6A patent/BR0114610A/pt not_active Withdrawn
- 2001-10-09 JP JP2002534317A patent/JP4252797B2/ja not_active Expired - Fee Related
- 2001-10-09 EP EP01979582A patent/EP1326865B1/en not_active Expired - Lifetime
- 2001-10-09 AT AT01979582T patent/ATE430745T1/de not_active IP Right Cessation
- 2001-10-09 AU AU2002211874A patent/AU2002211874A1/en not_active Abandoned
- 2001-10-09 WO PCT/US2001/042564 patent/WO2002030931A2/en not_active Application Discontinuation
- 2001-10-09 WO PCT/US2001/031456 patent/WO2002030930A2/en active Application Filing
- 2001-10-09 EE EEP200300145A patent/EE200300145A/xx unknown
- 2001-10-09 IL IL15508901A patent/IL155089A0/xx unknown
- 2001-10-09 PL PL01360944A patent/PL360944A1/xx not_active Application Discontinuation
- 2001-10-09 CA CA2425440A patent/CA2425440C/en not_active Expired - Fee Related
- 2001-10-09 SK SK432-2003A patent/SK4322003A3/sk unknown
- 2001-10-10 US US09/973,853 patent/US6921759B2/en not_active Expired - Fee Related
- 2001-10-11 AR ARP010104777A patent/AR033845A1/es not_active Application Discontinuation
- 2001-10-11 PE PE2001001008A patent/PE20020509A1/es not_active Application Discontinuation
-
2003
- 2003-03-26 BG BG107677A patent/BG107677A/bg unknown
- 2003-03-27 IS IS6760A patent/IS6760A/is unknown
- 2003-04-11 NO NO20031672A patent/NO20031672L/no not_active Application Discontinuation
-
2005
- 2005-02-11 US US11/056,412 patent/US20050176718A1/en not_active Abandoned
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